Descriptive analysis of different phenotypes of cardiac remodeling in fetal growth restriction

Rodríguez‐López, Mérida; Cruz‐Lemini, M.; Valenzuela-Alcaráz, Brenda; García‐Otero, Laura; Sitges, Marta; Bijnens, Bart; Gratacós, Eduard; Crispi, F.

doi:10.1002/uog.17365

Cited by 79 publications

(124 citation statements)

References 32 publications

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“…fell outside the reference lines from the current study, the 5 th centile in the study by Perez‐Cruz et al . fell below our current 5 th centile reference line for both right and left ventricles, and the 5 th centile in the study by Rodriguez‐Lopez et al . fell below our 5 th centile for the left ventricle.…”

Section: Resultscontrasting

confidence: 79%

“…Figure illustrates the Z ‐scores for the four previously published studies compared with ours ( Z ‐score = 0); the right ventricular 5 th and 95 th centiles in the study by Cruz‐Lemini et al . fell outside the reference lines from the current study, the 5 th centile in the study by Perez‐Cruz et al .…”

Section: Resultssupporting

confidence: 40%

“…Using the mean and SD for Segment 1 (basal segment) from our current study and from previously published studies, we computed the SI, SI Z ‐score and SI Z ‐score centile for each of the study cases (Table , Appendix S3). Compared with our system, classifying our fetuses according to Perez‐Cruz et al .…”

Section: Resultsmentioning

confidence: 99%

“…While the P ‐values indicated significant difference between the control and study groups, a threshold (e.g. 5 th , 10 th , 90 th or 95 th centile) for classification of fetuses was not provided. For this reason, we used the mean and SD for each of the 24 segments (Table ) of the right and left ventricles to compute reference centiles (Table ) that can be used to classify SI in fetuses with suspected pathology.…”

Section: Discussionmentioning

confidence: 99%

“…In their studies, Valenzuela‐Alcaraz et al . and Rodriguez‐Lopez et al . provided mean and interquartile values for the basal segment SI for right and left ventricles.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

24‐segment sphericity index: a new technique to evaluate fetal cardiac diastolic shape

DeVore

Klas²,

Satou

et al. 2018

Ultrasound in Obstet & Gyne

141

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Section: Resultscontrasting

confidence: 79%

Section: Resultssupporting

confidence: 40%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In their studies, Valenzuela‐Alcaraz et al . and Rodriguez‐Lopez et al . provided mean and interquartile values for the basal segment SI for right and left ventricles.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

24‐segment sphericity index: a new technique to evaluate fetal cardiac diastolic shape

DeVore

Klas²,

Satou

et al. 2018

Ultrasound in Obstet & Gyne

141

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show abstract

Understanding the preterm human heart: What do we know so far?

Schuermans

Lewandowski

2022

The Anatomical Record

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Globally, preterm birth affects more than one in every 10 live births. Although the short-term cardiopulmonary complications of prematurity are well known, long-term health effects are only now becoming apparent. Indeed, preterm birth has been associated with elevated cardiovascular morbidity and mortality in adulthood. Experimental animal models and observational human studies point toward changes in heart morphology and function from birth to adulthood in people born preterm that may contribute to known long-term risks.Moreover, recent data support the notion of a heterogeneous cardiac phenotype of prematurity, which is likely driven by various maternal, early, and late life factors. This review aims to describe the early fetal-to-neonatal transition in preterm birth, the different structural and functional changes of the preterm human heart across developmental stages, as well as potential factors contributing to the cardiac phenotype of prematurity.

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Assessment of fetal cardiac morphology and functional changes in early‐onset and late‐onset fetal growth restriction

Oluklu

Beşer

Hendem

et al. 2022

Intl J Gynecology & Obste

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Objective To compare the fetal cardiac morphology and functions of early‐onset fetal growth restriction (EO‐FGR) and late‐onset fetal growth restriction (LO‐FGR) groups with gestational weeks‐matched controls. Methods A total of 164 pregnant women were included, 28 of whom were in the EO‐FGR group, 54 in the LO‐FGR group, and 82 in the control group. Fetal echocardiographic evaluation was performed with two‐dimensional, M‐mode, tissue Doppler imaging (TDI), and pulsed wave Doppler. Results Fetal cardiac morphologic measurements and diastolic and systolic functions changed in EO‐FGR and LO‐FGR fetuses compared with controls. The EO‐ and LO‐FGR fetuses had reduced right and left cardiac output, increased myocardial performance index, and significantly higher mitral and tricuspid E/E' ratios compared with controls. The EO‐FGR fetuses had lower mitral and tricuspid E and E' values. In LO‐FGR fetuses, mitral and tricuspid E' values were lower than in their controls (P = 0.001 and P < 0.001). On the other hand, the mitral and tricuspid E values were not significantly changed (P = 0.107 and P = 0.196). Conclusion We hypothesized that EO‐FGR and LO‐FGR fetuses had insufficient myocardial maturation. Especially in the LO‐FGR fetuses, TDI is the earliest and most sensitive technique to show subtle changes in fetal cardiac functions.

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Descriptive analysis of different phenotypes of cardiac remodeling in fetal growth restriction

Cited by 79 publications

References 32 publications

24‐segment sphericity index: a new technique to evaluate fetal cardiac diastolic shape

24‐segment sphericity index: a new technique to evaluate fetal cardiac diastolic shape

Understanding the preterm human heart: What do we know so far?

Assessment of fetal cardiac morphology and functional changes in early‐onset and late‐onset fetal growth restriction

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