Desaturation – distance ratio: a new concept for a functional assessment of interstitial lung diseases

Pimenta, Suzana Pinheiro; Rocha, Rachel de Oliveira; Baldi, Bruno Guedes; Kawassaki, Alexandre de Melo; Kairalla, Ronaldo Adib; Carvalho, Carlos Roberto Ribeiro

doi:10.1590/s1807-59322010000900005

Cited by 29 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One study in 49 people with ILD has shown a strong relationship between desaturation-distance ratio and measures of disease severity [171]. The prognostic value of this relatively complex measure has not been studied.…”

Section: Oxyhaemoglobin Saturationmentioning

confidence: 99%

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

Singh¹,

Puhan²,

et al. 2014

View full text Add to dashboard Cite

This systematic review examined the measurement properties of the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease.Studies that report the evaluation or use of the 6MWT, ISWT or ESWT were included. We searched electronic databases for studies published between January 2000 and September 2013.The 6-min walking distance (6MWD) is a reliable measure (intra-class correlation coefficients ranged from 0.82 to 0.99 in seven studies). There is a learning effect, with greater distance walked on the second test (pooled mean improvement of 26 m in 13 studies). Reliability was similar for ISWT and ESWT, with a learning effect also evident for ISWT (pooled mean improvement of 20 m in six studies). The 6MWD correlates more strongly with peak work capacity (r50.59-0.93) and physical activity (r50.40-0.85) than with respiratory function (r50.10-0.59). Methodological factors affecting 6MWD include track length, encouragement, supplemental oxygen and walking aids. Supplemental oxygen also affects ISWT and ESWT performance. Responsiveness was moderate to high for all tests, with greater responsiveness to interventions that included exercise training.The findings of this review demonstrate that the 6MWT, ISWT and ESWT are robust tests of functional exercise capacity in adults with chronic respiratory disease. OverviewThe aim of this systematic review was to examine the measurement properties for the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease. A companion paper describes the standard operating procedures for the tests [1]. The key findings of this systematic review are as follows.1) The 6-min walking distance (6MWD) is a valid and reliable measure of exercise capacity for people with chronic lung disease. The 6MWD correlates more strongly with measures of peak work capacity and physical activity than with respiratory function or quality of life, which supports its conceptualisation as a test of functional exercise performance.2) The ISWT offers a different protocol to the 6MWT as it is incremental and externally paced. The ISWT is a valid and reliable measure of cardiopulmonary exercise capacity in chronic obstructive pulmonary disease (COPD), where there is a strong relationship between ISWT distance and peak oxygen uptake (V9O 2 peak) or work rate on a cardiopulmonary exercise test (CPET).3) A learning effect is observed for the 6MWT and the ISWT. The second test usually is the better compared with the first, but this is inconsistent.4) The ESWT is a test of endurance capacity. It is externally paced and is performed along the same course as the ISWT. Two tests do not appear to be necessary if the second test is conducted on the same day.5) Reference equations have been proposed for the 6MWD and the ISWT. Age, height and weight are included in most equations. The influence of race and ethnicity is unclear.6) The safety profile of ...

show abstract

Section: Oxyhaemoglobin Saturationmentioning

confidence: 99%

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

Singh¹,

Puhan²,

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Generally, interstitial lung disease shows restrictive abnormalities, including lung volume reduction and the involvement of alveolar-capillary membranes, which reduces the 6MWT distance and lowest S pO 2 during 6MWT, due to a disturbance in gas exchange. 15 The reduced percent-of-predicted D LCO in the desaturation group was most severe, at 45.8% on average, among the lung function parameters. The percent-of-predicted D LCO /V A was also low, whereas the area under the receiver operating characteristic curve of the percent-ofpredicted D LCO was larger than that of D LCO /V A .…”

Section: Discussionmentioning

confidence: 82%

Predictors of Exercise-Induced Oxygen Desaturation in Systemic Sclerosis Patients With Interstitial Lung Disease

Someya

Mugii²,

Hasegawa

et al. 2013

Respir Care

View full text Add to dashboard Cite

BACKGROUND:The diffusion capacity of the lung for carbon monoxide (D LCO ) is a good marker of disease severity in patients with idiopathic interstitial pneumonia, and is associated with oxygen saturation; however, little is known about D LCO in systemic sclerosis patients with interstitial lung disease. We studied potential predictors of exercise-induced oxygen desaturation in patients with systemic sclerosis. METHODS: Data were collected prospectively from 80 of 110 consecutive systemic sclerosis patients with normal oxygen saturation (> 95%) at rest, who could perform the 6-min walk test without physical discomfort, including leg pain. Pulmonary function tests and echocardiography were collected from all subjects. RESULTS: Thirty subjects showed a > 4% decline in oxygen saturation during the 6-min walk test (desaturation group). The other subjects were assigned to the normoxic group. The percent-of-predicted values for FVC, FEV 1 , total lung capacity, D LCO , and D LCO /alveolar volume were lower, and FEV 1 /FVC was higher, in the desaturation group. Logistic regression analysis showed the percent-of-predicted D LCO as a highly accurate predictor of exercise-induced oxygen desaturation: the area under the receiver operating characteristic curve was 0.92 (cutoff point 56.3%, sensitivity 0.83, specificity 0.86). Five subjects over the cutoff point of the percent-of-predicted D LCO in the desaturation group could not be distinguished from the normoxic subjects with the lung-volume measurements or right-ventricular systolic pressure. CONCLUSIONS: The factor underlying exercise-induced oxygen desaturation appeared to be reduced percent-of-predicted D LCO , which was useful as a predictor in over 80% of the subjects.

show abstract

“…Pimenta et al (21) proposed a new composite index (the desaturation-distance ratio), using continuous SpO 2 and the distance covered on the six-minute walk test. The authors concluded that the desaturation-distance ratio is a promising, reliable physiologic tool for the evaluation of interstitial lung disease.…”

Section: Infectious Diseasesmentioning

confidence: 99%

Pesquisas em pneumologia recentemente publicadas em revistas brasileiras

Gomes

Higa

2012

J. bras. pneumol.

View full text Add to dashboard Cite

We reviewed original articles in the field of pulmonary medicine that had been recently published in 12 Brazilian journals-general or specialty journals-excluding the Brazilian Journal of Pulmonology. All were journals indexed for the Institute for Scientific Information Web of Knowledge. The selection of articles was based on the "continuously variable rating" concept. We have organized the articles by category.Keywords: Pulmonary medicine; Medical oncology; Research; Infectious disease medicine. ResumoRevisamos estudos originais no campo da pneumologia que foram recentemente publicados em 12 publicações gerais ou de especialidades -que não o Jornal Brasileiro de Pneumologia -indexadas no Institute for Scientific Information Web of Knowledge. A seleção dos artigos foi baseada no conceito de continuously variable rating, e os artigos foram classificados em categorias.

show abstract

Desaturation – distance ratio: a new concept for a functional assessment of interstitial lung diseases

Cited by 29 publications

References 28 publications

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

Predictors of Exercise-Induced Oxygen Desaturation in Systemic Sclerosis Patients With Interstitial Lung Disease

Pesquisas em pneumologia recentemente publicadas em revistas brasileiras

Contact Info

Product

Resources

About