Dermoscopic features of endocrine mucin‐producing sweat gland carcinoma

Abstract

Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is very rare, with only 61 cases reported to date. EMPSGC is considered to be a low-grade carcinoma of sweat gland origin. Dermoscopic findings of EMPSGC have not been previously reported. We report the first case of a man with EMPSGC, featuring dermoscopic findings. Dermoscopic examinations of the present EMPSGC lesion revealed tumor cell proliferation that appeared as pink ovoid nests and elongated epidermis that resembled a whitish-pink network. Another characteristic finding of the present lesion was the large red/blue globules in pink ovoid nests in the tumor. Those reflected lacunae containing secretory fluid with red blood cells. We think that the large red/blue globules in pink ovoid nests in our case could be a characteristic dermoscopic finding specific to EMPSGC. We dermatologists encounter many "pink nodules" at out-patient clinics. The present dermoscopic findings may be useful for the differential diagnosis of EMPSGC.

Comparative performance of insulinoma‐associated protein 1 (INSM1) and routine immunohistochemical markers of neuroendocrine differentiation in the diagnosis of endocrine mucin‐producing sweat gland carcinoma

“…[1][2][3] It presents as a slow-growing skincolored nodule, papule, or cyst. 4 Thus, the clinical differential diagnosis is quite broad. Importantly, however, EMPSGC shows substantial histomorphologic overlap with metastatic adenocarcinoma, which must carefully be excluded by evaluation of both the histomorphology and immunophenotype.…”

Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic, immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression

“…Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare low‐grade primary cutaneous sweat gland carcinoma with predilection for the periorbital skin in elderly female patients. Around 70 cases of EMPSGC have been reported so far (Table ). The tumor exhibits morphologic and immunophenotypical similarity to endocrine ductal carcinoma in situ (DCIS) or solid papillary carcinoma of the breast .…”

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

“…Although their color might vary from white to blue-grey, the tumors are generally skin-colored, sometimes with erythema or telangiectasia. Lesions may occur in various parts of the body, where apocrine or eccrine glands are located [ 5 , 11 , 42 , 45 , 54 , 95 , 102 , 123 , 164 , 268 , 287 ].…”

“…The lesion, usually found on the periorbital skin and the eyelid (~66%), is frequently skin-colored, slowly growing nodule, cyst, or swelling with associated erythema, telangiectasia, and madarosis [ 102 ]. Dermatoscopic features include pink aggregations to reddish globules (pink ovoid nests) that show a cobblestone appearance, and each globule is separated with white to pink meshes of bands [ 103 ].…”

“…Progression might be signified by pools of extracellular stromal mucin and/or infiltrating tumor glands and nests that lacked an intact myoepithelial rim. Immunohistochemical findings include CK5/6, CK8 and CK18, CAM5.2, WT1, GCDFP15, ER, PR, and variable expression of synaptophysin, chromogranin, and neuron-specific enolase [ 99 , 101 , 102 , 104 , 105 , 106 , 107 ]. Myoepithelial markers such as calponin, actin, p63, and S100 might help to detect myoepithelial cells [ 106 , 108 ].…”