Dermoepidermal Interface

Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing

“…Topologically, the rete ridges form an interlacing network of channels on the dorsum of Lanyu pigs (Figure ) . This 3‐dimensional architecture of rete ridges has not been fully addressed .…”

“…[18,28] Although the mouse model is powerful due to genetic manipulation, mouse skin lacks prominent rete ridges or a signifi- Topologically, the rete ridges form an interlacing network of channels on the dorsum of Lanyu pigs (Figure 3). [21,22] This 3-dimensional architecture of rete ridges has not been fully addressed. [20] Understanding how the rete ridge network develops is fundamental to wound healing studies.…”

“…The topology of rete ridges introduces architectural complexity that cannot be studied using traditional animal models that lack rete ridges, for example the loose‐skinned animals of mice, rats or rabbits. Rete ridges form a lattice network of channels . Furthermore, lineage tracing studies for rete ridge development and biology in humans are not currently possible.…”

“…Rete ridges form a lattice network of channels. [21,22] Furthermore, lineage tracing studies for rete ridge development and biology in humans are not currently possible. Rete ridge possessing animal models, combined with human explant tissues, that utilize 3-dimensional (3D) spatiotemporal techniques would be advantageous.…”

Stéréologie de l’interface dermo-épidermique

“…La stéréologie d'une telle structure anfractueuse décrite par O berste- Lehn [1962], peut être précisée en microscopie électronique par balayage. L'utilisation de cette technique nécessite la séparation préalable du derme et de l'épiderme au niveau de leur interface.…”