Dermatomyositis and Diffuse Scleroderma

Viscero-cutaneous Collagenosis: A Study of the Intermediate Forms of Dermatomyositis, Scleroderma, and Disseminated Lupus Erythematosus

“…This remark still holds good. Brock (1934) noted in his Case 4 an increase of periportal connective tissue. Perdomo de Fernandez, Ravera, and Piovano (1951) performed a liver biopsy on a man aged 43 with scleroderma, whose liver was palpable two fingerbreadths below the costal margin.…”

Polymyositis

“…With regard to the prognosis of polymyositis and dermatomyositis, it is now well recognized that up to 50% of the florid cases terminate fatally, usually from pharyngeal or respiratory paralysis or from associated bronchopneumonia. In many of the others the disease becomes arrested, with varying amounts of residual disability (Oppenheim, 1903;Brock, 1934;O'Leary and Waisman, 1940;Sheard, 1951).…”

Scleroderma With Heart Failure

“…Matsui (1924) studied six patients, all females, everyone of whom showed cardio-vascular involvement, such as cardiac hypertrophy and dilatation, mainly right-sided, and myocardial fibrosis. Heine (1926) and Brock (1934) published cases in which the cause of death was heart failure. Weiss et alii (1943) recorded nine cases of scleroderma and cardiac symptoms or signs; two of these patients came to autopsy.…”