Dermatological Problems Among Pharmaceutical Workers

Dalton, John Eric

doi:10.1001/archderm.1951.01570120002001

Cited by 7 publications

(2 citation statements)

References 2 publications

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“…The patch test was positive and 9 other workers were also positive. None of these reacted to the vitamin orally ( 4). There is only 1 report of contact allergy to an intermediate (ethoxymethylmalodinitril) in the production of vitamin B 1 (5).…”

Section: Discussionmentioning

confidence: 99%

“…Allergic contact stomatitis is the main clinical effect produced by palladium contained in metal alloys used in dental prostheses (1)(2)(3). An occupational case has been described in a chemist working for 6 months with precious metals and developing a sensitization to palladium (4). Recently, 2 cases of sensitization to palladium have also been described in connection with the patients' hobbies (5), though the sources of palladium in both cases were not clear (5).…”

Section: Discussionmentioning

confidence: 99%

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Allergic contact dermatitis from thiamine

Larsen¹,

Jepsen²,

Thulin

1989

Contact Dermatitis

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Allergic contact dermatitis is mainly associated with xenobiotics and rarely with essential substances such as vitamins. Cronin (!) has surveyed previous case reports. Thiamine is vitamin Bl. Case ReportsCase no. 1. A 54-year-old nonatopic former grocer, employed in a pharmaceutical plant, filled and packed thiamine hydrochloride in a dusty process. After I month, he developed an itchy eczema on the forearms and dorsa of the hands, with some spread to the face.His condition did not improve with plastic gloves over most of the affected areas of the upper limbs, but disappeared on treatment with budesonide cream and 3 weeks off work. A severe flare-up followed immediately after resuming work, and he had to stop any work in contact with thiamine. He had had no recent oral intake of thiamine.Patch tests with thiamine 10%, 5% and I% aq. and thiothiamine 5% and I% aq. were applied with Finn Chambers® and read at 48 and 72 h, showing positive reactions to thiamine 10% and 5% aq.: thiamine I% aq. showed erythema only. Positive reactions were also recorded to thiothiamine 5% and 1% aq. A positive reaction was found to the inside of the used, but not the new, gloves. Testing with the European standard series was negative. Case no. 2A 32-year-old former baker had had to change his occupation due to rhinoconjunctivitis. Allergy was found to rye and a number of grass and tree pollens. 6 years earlier, he had for a short period been treated for atopic dermatitis. After 3 months of employment as a process worker in the same pharmaceutical plant as case no. I, he developed an itchy eczema on the hands and legs, which spread to the rest of the body. The eczema was exudative in places. On the dorsa of the hands and feet, it was severely infiltrated and more proximally, it had a reticular pattern.The patient was dismissed from work. The skin gradually cleared after treatment with betamethasone ointment. After discontinuation of topical treatment, however, an intermittent itchy dermatitis persisted on the dorsa of the feet, on the face, and occasionally at other sites. Further questioning revealed that daily he took oral vitamins containing thiamine.Patch testing (European standard series) showed positive reactions to formaldehyde and fragrance mix. He also reacted to thiamine hydrochloride 10% aq. The 2 former reactions were not considered relevant to the present dermatitis. Oral thiamine was discouraged.Patch testing of controls 10 other patients were tested with thiamine hydrochloride 5% and 10% pet. and aq. All patients had eczema but no known external contact with thiamine hydrochloride. They were all negative to all tests. DiscussionCases of allergic contact dermatitis due to thiamine have previously been reported among pharmaceutical workers. 2 patients filling ampoules developed allergic eczema of the hands and arms, and in I also of the eyelids (2). A girl filling vials developed ec-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis from thiamine

Larsen¹,

Jepsen²,

Thulin

1989

Contact Dermatitis

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2,4,6‐Trinitrophenol (Pikrinsäure) [MAK Value Documentation in German language, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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Picric acid [MAK Value Documentation, 2002]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 17 (2002) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Man Single exposures Repeated exposures Local effects on skin and mucous membranes Allergenic effects Animal Experiments and in vitro Studies Acute toxicity Local effects on skin and mucous membranes Allergenic effects Genotoxicity Manifesto (MAK value/classification)

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Dermatological Problems Among Pharmaceutical Workers

Cited by 7 publications

References 2 publications

Allergic contact dermatitis from thiamine

Allergic contact dermatitis from thiamine

2,4,6‐Trinitrophenol (Pikrinsäure) [MAK Value Documentation in German language, 1999]

Picric acid [MAK Value Documentation, 2002]

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