Dermatologic Manifestations of Endocrine Disorders

Raj, Rishi; Elshimy, Ghada; Mishra, Rahul; Jha, Nivedita; Joseph, Vismaya; Bratman, Russell; Tella, Sri Harsha; Correa, Ricardo

doi:10.7759/cureus.18327

Cited by 8 publications

(6 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include recurrent fungal or bacterial skin infections, lipoid necrobiosis, diabetic blisters, or autoimmune skin disorders. Diabetic dermopathy is the most common dermatological condition that can occur in up to 70% of adult patients with diabetes [ 59 ]. Although it is known that diabetes is associated with a series of skin manifestations, there are relatively few studies that analyze the prevalence of skin changes in young patients with type 1 diabetes.…”

Section: T1dmand Autoimmune Endocrine Pathologymentioning

confidence: 99%

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Popoviciu

Kaka²,

Sethi

et al. 2023

JPM

View full text Add to dashboard Cite

Type 1 Diabetes Mellitus (T1DM) is a common hyperglycemic disease characterized by the autoimmune destruction of insulin-producing beta cells of the pancreas. Various attempts have been made to understand the complex interplay of genetic and environmental factors which lead to the development of the autoimmune response in an individual. T1DM is frequently associated with other autoimmune illnesses, the most common being autoimmune thyroid disorders affecting more than 90% of people with T1D and autoimmune disorders. Antithyroid antibodies are present in around 20% of children with T1D at the start of the illness and are more frequent in girls. Patients with T1DM often have various other co-existing multi-system autoimmune disorders including but not limited to thyroid diseases, parathyroid diseases, celiac disease, vitiligo, gastritis, skin diseases, and rheumatic diseases. It is a consistent observation in clinics that T1DM patients have other autoimmune disorders which in turn affect their prognosis. Concomitant autoimmune illness might affect diabetes care and manifest itself clinically in a variety of ways. A thorough understanding of the complex pathogenesis of this modern-day epidemic and its association with other autoimmune disorders has been attempted in this review in order to delineate the measures to prevent the development of these conditions and limit the morbidity of the afflicted individuals as well. The measures including antibody screening in susceptible individuals, early identification and management of other autoimmune disorders, and adoption of personalized medicine can significantly enhance the quality of life of these patients. Personalized medicine has recently gained favor in the scientific, medical, and public domains, and is frequently heralded as the future paradigm of healthcare delivery. With the evolution of the ‘omics’, the individualization of therapy is not only closer to reality but also the need of the hour.

show abstract

Section: T1dmand Autoimmune Endocrine Pathologymentioning

confidence: 99%

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Popoviciu

Kaka²,

Sethi

et al. 2023

JPM

View full text Add to dashboard Cite

show abstract

“…The hypothesis is that his AN may be both paraneoplastic, as well as medication-induced. Classically, benign AN is associated with metabolic syndromes including obesity and hyperinsulinemia; however, hypoadrenalism is also an important cause [ 12 ]. Immune checkpoint inhibitor therapy has also been linked to primary adrenal insufficiency, with low serum cortisol levels detected in patients [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Acanthosis Nigricans in a Patient with Urothelial Carcinoma Treated with PD-L1 Inhibitor Avelumab, and Secondary Adrenal Insufficiency

Lai,

Jordan

2023

Case Rep Oncol

View full text Add to dashboard Cite

Acanthosis nigricans (AN) describes hyperkeratotic and hyperpigmented skin changes and its pathophysiology is linked to the activation of epidermal growth factor receptors. Current literature shows that AN is most commonly diagnosed at the time of the underlying pathology, which may occur under benign or malignant conditions. This case presentation demonstrates the occurrence of AN in a patient following the diagnosis of urothelial carcinoma and ongoing treatment with PD-L1 inhibitor immunotherapy. Subsequent investigations ruled out a secondary malignancy or disease progression; however, metabolic screening identified secondary glucocorticoid induced adrenal insufficiency. AN was persistent in this patient despite adequate treatment, which highlights its co-occurrence in both benign and paraneoplastic conditions.

show abstract

“…Endocrine disorders are known to involve all organ systems of the body, including the skin (Raj et al. 2021 ). The pathogenesis of acne involves several hormonal pathways, including androgens, insulin-like growth factor-1, oestrogens and corticosteroids (Rao et al.…”

Section: Discussionmentioning

confidence: 99%

Investigating material basis and molecular mechanism of Qing Cuo formula in the treatment of acne based on animal experiments, UPLC-LTQ-Orbitrap-MS and network pharmacology

Cao

Liang

Wang

et al. 2023

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Qing Cuo Formula (QCF) is a traditional Chinese medicine for treating acne, but its active compounds and molecular mechanisms are unclear. Objective To investigate the material basis and molecular mechanism of QCF. Materials and methods In vivo experiments were conducted on 60 male golden hamsters with damp-heat acne, with a blank group, a spironolactone group and 3 QCF administration groups (given high, medium and low doses) over a 30-day period. Serum androgen and inflammatory cytokine levels were tested by ELISA. In vitro , chemical compositions of QCF were investigated by UPLC-LTQ-Orbitrap-MS. Network pharmacology approaches were used to analyse the protein–protein interaction (PPI) network and QCF active compounds-intersection targets-acne network. GO enrichment and KEGG pathway analysis was conducted subsequently. Results Low-dose QCF group (11.4 g/kg/day) showed significantly reduced levels of serum T (4.94 ± 0.36; 5.51 ± 0.36 ng/mL), DHT (6.67 ± 0.61; 8.09 ± 0.59 nmol/L), E2 (209.01 ± 20.92; 237.08 ± 13.94 pg/mL), IL-1α (36.84 ± 3.23; 44.07 ± 4.00 pg/mL) and FFA (128.32 ± 10.94; 148.00 ± 12.12 µmol/L) compared to the blank group ( p < 0.05). In vitro experiments identified 75 compounds in QCF decoction, with 27 active compounds absorbed in serum. Network pharmacology identified 6 active components connecting 17 targets. GO enrichment and KEGG pathway analysis indicated that QCF’s anti-acne targets mainly regulate extracellular matrix function, inflammatory processes, immune response and endocrine function. Conclusions This study provides evidence of the molecular mechanism and material basis of QCF in treating androgen-related damp-heat acne, paving the way for further research on its potential in treating other conditions related to damp-heat constitution.

show abstract

Dermatologic Manifestations of Endocrine Disorders

Cited by 8 publications

References 68 publications

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Acanthosis Nigricans in a Patient with Urothelial Carcinoma Treated with PD-L1 Inhibitor Avelumab, and Secondary Adrenal Insufficiency

Investigating material basis and molecular mechanism of Qing Cuo formula in the treatment of acne based on animal experiments, UPLC-LTQ-Orbitrap-MS and network pharmacology

Contact Info

Product

Resources

About