Dermatohistopathology of Various Types of Scleroderma

O’leary, Paul A.

doi:10.1001/archderm.1957.01550130080008

Cited by 95 publications

(21 citation statements)

References 13 publications

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“…Electron microscopic observations revealed no significant changes. On the other hand, many of the mice given a 0.2% solution of the agent showed histologically sclero derma-like skin changes with features described in the literature [8,11]. These findings also resembled those of the biopsy specimens of patients exposed to epoxy resins.…”

Section: Experimental Skin Sclerosis Produced With Bis (4-amino-3-mefsupporting

confidence: 65%

Detection of Sclerosis-Inducing Glycosaminoglycan in the Skin of an Amine-Induced Experimental Skin Sclerosis

Ishikawa¹,

Yamakage²,

Kitabatake³

et al. 1980

Dermatology

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The presence of sclerosis-inducing glycosaminoglycan in the skin was confirmed in an experimental skin sclerosis induced by a chemical compound. An experimental skin sclerosis was first produced in the mouse with bis(4-amino-3-methylcyclohexyl)methane. Out of glycosaminoglycans isolated from the slightly changed skin of this experimental skin sclerosis, the one having a heparan sulfate-like structure was able to again induce sclerotic skin changes in another mouse. The chemical composition of this sclerosis-inducing glycosaminoglycan was somewhat similar to that of the scleroderma-inducing glycosaminoglycan isolated previously from the urine of patients with systemic scleroderma.

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Section: Experimental Skin Sclerosis Produced With Bis (4-amino-3-mefsupporting

confidence: 65%

Detection of Sclerosis-Inducing Glycosaminoglycan in the Skin of an Amine-Induced Experimental Skin Sclerosis

Ishikawa¹,

Yamakage²,

Kitabatake³

et al. 1980

Dermatology

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“…Statements such as "densely packed fibrils" and "eosinophilic changes" have not always been reproducible (18). The observation of a distinctive fibril with definite ultrastructural characteristics has been made by several laboratories, revealing a population of small, beaded fibrils similar to fibrils in embryonic skin and suggestive of newly synthesized collagen fibrils (19,20).…”

Section: Resultsmentioning

confidence: 99%

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

Ec¹

1974

J. Clin. Invest.

527

177

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A B S T R A C T Cultures of dividing skin fibroblasts from normal and sclerodermatous human skin have permitted estimations of soluble collagen concentration, net collagen accumulation, cell-doubling times, and the comparison of morphologic and ultrastructural characteristics. In vitro, the scleroderma fibroblast produces more soluble collagen, synthesizes collagen more rapidly, and fourfold more of its protein synthetic activity is directed to collagen production than in the normal skin fibroblast. Cell-doubling times and morphologic and ultrastructural observations of cells in culture have not provided clues to the nature of the biologic defect in the regulation or activation of collagen synthesis by the scleroderma fibroblast.

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“…The diagnostic criteria of GM vary among investigators. O'Leary et al (3) defined GM as numerous plaques, sometimes involving the entire trunk. Jablonska and Rodnan (4) reported GM as having all the features of LS with a considerable overlap with linear scleroderma and morphea.…”

Section: Discussionmentioning

confidence: 99%

Unilateral Generalized Morphea in Childhood

Nagai

Hattori

Ishikawa

2002

The Journal of Dermatology

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We report a 6-year-old boy with unilateral generalized morphea distributing on the right side of his lower leg, trunk, and upper arm. A skin biopsy from the right thigh showed accumulation of thick collagen bundles extending from the middle dermis to the subcutaneous fat tissue. The levels of antinuclear antibodies, rheumatoid factor, and anti single-stranded DNA antibody were elevated. No severe deformity or functional disabilities were noted. With topical corticosteroid therapy, the sclerotic skin became gradually softer, and no progression of sclerosis has been noted for one year.

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Dermatohistopathology of Various Types of Scleroderma

Cited by 95 publications

References 13 publications

Detection of Sclerosis-Inducing Glycosaminoglycan in the Skin of an Amine-Induced Experimental Skin Sclerosis

Detection of Sclerosis-Inducing Glycosaminoglycan in the Skin of an Amine-Induced Experimental Skin Sclerosis

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

Unilateral Generalized Morphea in Childhood

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