Dermatitis herpetiformis in association with systemic lupus erythematosis

Moncada, Benjamín

doi:10.1001/archderm.109.5.723

Cited by 34 publications

(12 citation statements)

References 12 publications

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“…The Ig deposits must be on or beneath the lamina densa to exclude BP or|; other primary subepidermal bullous diseases associated with antibodies to hemidesmosomal or lamina lucida antigens. It is important to exclude DH because several of its features resemble bullous SLE, and a number of patients with both disorders have been reported [17][18][19][20][21]. Some of those may have been patients with bullous SLE [4,22].…”

Section: Criteria For the Bullous Sle Phenotype And* Exclusion Of Othmentioning

confidence: 99%

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Gammon¹,

Briggaman²

1993

J Invest Dermatol

108

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Bullous systemic lupus erythematosus (SLE) is a rare blistering disease with a distinctive combination of clinical, histologic and immunopathologic features that together constitute a unique bullous disease phenotype. There appear to be at least two immunologically distinct subtypes of bullous SLE characterized by the presence or absence of circulating and/or tissue-bound basement membrane zone autoantibodies that recognize type VII collagen. The two subtypes are not clearly distinguishable except by indirect immunofluorescence and/or direct immunoelectron microscopy. In patients without circulating antibodies, immunoelectron microscopy is required to distinguish between the two subtypes. Patients with autoantibodies to type VII collagen are similar but not identical to patients with epidermolysis bullosa acquisita--another bullous disease associated with autoantibodies to type VII collagen. Autoantibodies to type VII collagen in patients with bullous SLE is only one of several lines of evidence that indicate autoimmunity to that protein and susceptibility to SLE are associated phenomena. In addition, there is emerging evidence for an association between epidermolysis bullous acquisita and SLE. There is also evidence that autoantibodies to type VII collagen are pathogenic in bullous SLE (and epidermolysis bullosa acquisita) and that their production is regulated by the class II major histocompatibility complex DR beta 1 allele, 1501 and possibly other DR beta 1 alleles that share a similar sequence of amino acids in the second hyper-variable region.

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Section: Criteria For the Bullous Sle Phenotype And* Exclusion Of Othmentioning

confidence: 99%

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Gammon¹,

Briggaman²

1993

J Invest Dermatol

108

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“…Bullous lesions in patients with SLE have been a source of difficulty in diagnosis owing to the fact that several other bullous diseases such as bullous pemphigoid [43][44][45][46] and dermatitis herpetiformis 47,48 have been reported concomitantly with SLE Bullous lesions occur due to intense hydropic degeneration of the basal layer of the epidermis. 49 Although they are considered by some authors to be specific to SLE, they can occur on the edges of annular SCLE lesions.…”

Section: Bullous Lementioning

confidence: 99%

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

Berbert

Mantese

2005

An. Bras. Dermatol.

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Lupus erythematosus is a connective tissue autoimmune disorder that demonstrates systemic, cutaneous, or both systemic and cutaneous manifestations. Cutaneous lesions are classified as specific and nonspecific. The variety of clinical manifestations of the disease is reflected in the broad spectrum of laboratory patterns. In this article we describe the distinct subsets of cutaneous lupus erythematosus, correlating them with histopathological, direct immunofluorescence and serological findings. Keywords: Skin diseases; Autoimmune diseases; Collagen diseases; Connective tissue diseases; Lupus erythematosus, Cutaneous/classification; Lupus erythematosus, Cutaneous/diagnosis. Resumo: O lúpus eritematoso é doença auto-imune do tecido conjuntivo que reúne manifestações exclusivamente cutâneas ou multissistêmicas, podendo apresentar exuberância de auto-anticorpos. As lesões cutâneas do lúpus eritematoso são polimorfas e podem ser específicas ou inespecíficas. A diversidade de manifestações clínicas da doença reflete-se no amplo espectro de achados laboratoriais. Este artigo descreve as variadas formas clínicas do lúpus eritematoso cutâneo correlacionan

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“…Eine seltene, atypische Variante ist der bullöse Lupus erythematodes [2,11,16]. Weit weniger bekannt sind aber die Assoziationen von echten Blasenkrankheiten der Haut mit System-Erythematodes [7,10,13]. Anhand eines während 3 Jahren beobachteten Krankheitsfalles möchten wir auf die Schwierigkeiten der Abgrenzung einer derartigen Assoziation vom bullösen Lupus erythematodes hinweisen.…”

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“…Bei Assoziation eines bullösen Pemphigoids mit viszeralem Lupus erythematodes kann es aber zu Inter pretationsschwierigkeiten kommen, besonders wenn im IIF-Test zirkulie rende Antikörper gegen die Basalmembran fehlen [7], Das gemeinsame Vorkommen von Dermatitis herpetiformis und SystemErythematodes ist äusserst selten. Ein Fall wurde 1974 von M oncad a [13] publiziert. Der Autor stützt sich bei der Diagnose vor allem auf die irnmunfiuoreszenzmikroskopischen Merkmale des Lupus erythematodes visceralis und den klinischen und histologischen Befund der Dermatitis herpetiformis.…”

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“…I) in Blasennähe und in frisch erkrankter Haut (erythematöse Plaques) unter der Basalmembran und in den Hautpapillen Immunglobulinkomplexe von vorwiegend granulärem Aspekt, welche zumeist der IgA-Klasse ange hören. Sie erlauben eine Abgrenzung gegen den isolierten viszeralen Lupus erythematodes [4,6,7,12,13,15,17,19], Bei Assoziation einer Dermatitis herpetiformis mit System-Erythematodes muss aber auch hier mit lnterpretationsschwierigkeiten gerechnet werden, welche eine sichere Diagnose er schweren. Entsprechende Literaturangaben fehlen.…”

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Diagnostische Probleme beim gleichzeitigen Auftreten von bullösen Dermatosen und Lupus erythematodes visceralis

Meyer¹,

Jenni²,

Krebs³

1976

Dermatology

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This report describes a patient, whom we observed for 3 years, exhibiting a coincidence of dermatitis herpetiformis Duhring and systemic Lupus erythematosus. The difficulties involved in demarcating bullous lupus erythematosus from the more rare association of bullous pemphigoid or dermatitis herpetiformis with systemic lupus erythematosus are discussed in connection with differential, histological, direct and indirect immunofluorescence diagnostic aids.

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Dermatitis herpetiformis in association with systemic lupus erythematosis

Cited by 34 publications

References 12 publications

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Bullous SLE: A Phenotypically Distinctive but Immunologically Heterogeneous Bullous Disorder.

Lúpus eritematoso cutâneo: aspectos clínicos e laboratoriais

Diagnostische Probleme beim gleichzeitigen Auftreten von bullösen Dermatosen und Lupus erythematodes visceralis

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