Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1

Olbricht, S. M.

doi:10.1001/archderm.122.4.418

Cited by 14 publications

(9 citation statements)

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“…The ori gin of the granular papillary immune deposits of the IgA class in DH is uncertain. Unsworth et al [6] sug gested gut-associated plasma cells as the source of IgA in the DH skin but this was not accepted by others [7][8][9]13]. In the current study, both subclasses of IgA were detected in the skin of DH patients.…”

Section: Discussioncontrasting

confidence: 67%

“…They concluded from their studies that IgA in DH skin is dimeric since it was associated with J-chain and could bind a secretory component. In contrast, Hall et al [7], Hall and Lawley [8] and Olbricht et al [9] could only demonstrate IgA 1 in the immune deposits of normal skin biopsies from 22 DH patients. Egelrud [13], on the other hand, reported that the primary IgA subclass in these immune deposits is IgA 1 and not IgA2 [13].…”

Section: Discussionmentioning

confidence: 96%

“…Based on their studies of the presence of J-chain and its binding ability to secretory component, these authors con cluded that IgA immune deposits are of gut origin. Hall et al [7], Hall and Lawley [8] and Olbricht et al [9], using monoclonal antibodies to IgA 1 and IgA2, on the other hand, concluded that the immune depos its are of IgAl, and not of IgA2 subclass. The reason for these discrepant results is not clear.…”

Section: Introductionmentioning

confidence: 99%

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Identification of IgA Subclasses in Skin of Dermatitis Herpetiformis Patients

Barghuthy

Kumar²,

Valeski³

et al. 1988

Int Arch Allergy Immunol

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There is a controversy as to the origin and to the subclass of IgA in dermatitis herpetiformis (DH) skin. The present study was undertaken to reexamine the subclasses of IgA and the presence of J-chain in biopsies of DH patients. Skin biopsies from 12 DH patients were examined for IgA, its subclasses and for J-chain by a modified direct immunofiuorescence (IF) method. All DH skin biopsies were positive for IgA. Ten of the twelve biopsies were positive for IgA1. IgA2 was detected in only 3 cases, notably in those which gave the strongest IgA reactions. In general, the fluorescent staining intensity for IgA2 was weaker than IgA1 and IgA1 was less than the total IgA. This may be due to differences in the concentrations of the immunoglobulin subclasses in the skin and may also be due to the restricted specificity of antisera used in the study. Direct IF studies of the presence of J-chain yielded negative findings in all DH cases examined including those which were positive for IgA2. The higher frequency of IgA1 over that of IgA2 and the absence of J-chain indicate that the IgA immune deposits in the DH skin may not necessarily be of mucosal origin.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Identification of IgA Subclasses in Skin of Dermatitis Herpetiformis Patients

Barghuthy

Kumar²,

Valeski³

et al. 1988

Int Arch Allergy Immunol

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“…Cutaneous IgA in DH consisted of both IgA1 and IgA2, although IgA1 predominated, however there are data about findings of IgA1 alone in the DH skin [39]. A recent study has also shown the increased skin-homing potential of IgA1-plasmablast compared with IgA2 cells in DH [40], what may be related with previous papers that demonstrated IgA1 deposits in the skin of DH patients [41,42]. Therefore, presented findings suggest that an increased skin-homing potential of IgA1 cells compared with IgA2 cells in DH could contribute to the formation of IgA1 deposits in the skin of DH patients.…”

Section: Discussionsupporting

confidence: 54%

IgA autoantibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase are associated, but unrelated to neutrophil elastase expression in lesional skin in human dermatitis herpetiformis

Gornowicz‐Porowska¹,

Seraszek‐Jaros²,

Kaczmarek³

et al. 2012

pdia

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A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: : Assist. Prof Original paper A b s t r a c t I In nt tr ro od du uc ct ti io on n: : In dermatitis herpetiformis (DH), activation of neutrophils via IgA Fc receptors (e.g. CD89) and immunocomplexes containing IgA1 may lead to the release of proteolytic enzymes, mainly neutrophil elastase (NE), destruction of the dermal-epidermal junction and blister formation. A Ai im m: : To analyze whether there are associations between levels of circulating IgA autoantibodies to epidermal (eTG) and tissue (tTG) transglutaminases, nonapeptides of gliadin (npG) and the intensity of cutaneous NE expression in patients with DH. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Altogether, 31 patients with DH were studied. The levels of serum IgA autoantibodies to eTG, tTG and npG were evaluated with ELISAs. The intensity of NE expression was estimated with immunohistochemistry using NE monoclonal antibody and quantitative digital morphometry. Statistical analysis was done using Spearman's rank correlation coefficient. R Re es su ul lt ts s: : There were no statistically significant correlations between the intensity of cutaneous NE expression and the levels of serum IgA autoantibodies to eTG, tTG, npG in patients with DH. There were statistically significant correlations between the levels of IgA autoantibodies to eTG, tTG, npG. C Co on nc cl lu us si io on ns s: : It seems that in human DH the activation of neutrophils, judged by the NE expression, is unrelated to the levels of serum IgA autoantibodies to eTG/tTG/npG, but all those autoantibodies in DH are produced in a coordinated way.K Ke ey y w wo or rd ds s: : dermatitis herpetiformis, neutrophil elastase, transglutaminases, gliadin.

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“…In humans, IgA1 is a predominant subclass in the sera, and IgA2 prevails in mucosal secretions of the colon [1]. Immunofluorescence analysis with monoclonal antibodies revealed that IgA1 without IgA2 was found in the cutaneous deposits in all four patients examined in an early study [5]. It was therefore speculated that both IgA1 and IgA2 may be produced in the pathologic gut-associated lymphoid tissue, but only IgA1 is involved in the production of cutaneous lesions [5].…”

Section: Introductionmentioning

confidence: 99%

Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis

Gornowicz‐Porowska

Bowszyc‐Dmochowska

Seraszek‐Jaros

et al. 2012

The Scientific World Journal

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Dermatitis herpetiformis (DH) is an autoimmunity-driven inflammatory blistering dermatosis associated with a gluten-dependent enteropathy. Tissue transglutaminase (tTG) and nonapeptides of gliadin (npG) are considered in its pathomechanism/diagnostics. Here, the diagnostic accuracy of anti-tTG/anti-npG IgA ELISAs in Slavic DH patients with active skin rash was assessed through creating receiver operating characteristic (ROC) curves, determining cutoff values, and calculating correlations between levels of anti-tTG/anti-npG IgA in DH, IgA/neutrophil-mediated non-DH patients and healthy persons. Altogether, sera from 80 Slavic individuals were examined. There were negligible differences between cutoff points obtained by the ELISAs manufacturer and those in this study. There were statistically significant correlations between levels of anti-tTG/anti-npG IgA in both DH group and the group of IgA/neutrophil-mediated non-DH dermatoses. There was no such correlation in healthy controls. It seems that IgA autoantibodies to tTG and npG in the IgA/neutrophil-mediated DH are produced in the coordinated way implying their causal relationship.

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Dermatitis herpetiformis. Cutaneous deposition of polyclonal IgA1

Cited by 14 publications

References 0 publications

Identification of IgA Subclasses in Skin of Dermatitis Herpetiformis Patients

Identification of IgA Subclasses in Skin of Dermatitis Herpetiformis Patients

IgA autoantibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase are associated, but unrelated to neutrophil elastase expression in lesional skin in human dermatitis herpetiformis

Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis

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