Dermatitis From Sulfanilamide

Frank, Louis J.

doi:10.1001/jama.1937.02780390013006

Cited by 32 publications

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“…The majority of clinical photosensitization is induced by a limited number of pharmacological substances; the sulphonamides and their derivatives, tetracyclines, phenothiazines, nonsteroidal anti-inflammatory drugs (1). The sulphonamides were the first systemic administred chemotherapeutics reported to induce this side effect in man (2)(3)(4). These reports were the reason for Stephan Epstein to choose sulfanilamide for his experiments (5).…”

mentioning

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Photodegradation products of sulphonamide‐derived oral antidiabetics and diuretics are not phototoxic in vitro

Selvaag

Thune

1996

Photoderm Photoimm Photomed

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The oral antidiabetics glibenclamide and glipizide, and the diuretics bendroflumethiazide and furosemide, all sulphonamide derived drugs, were investigated in vitro for phototoxic properties. Irradiation with broad-band UV induced phototoxic inhibition of colony forming ability in cell cultures. During irradiation, the substances lost one absorption maximum in the UVA region, demonstrated by UV spectroscopy. These findings correlate well with the UV applied, the action spectrum being in the UVA region. Photoproducts detected during and after irradiation showed a decomposition of the substances due to ionization and fragmentation. Incubation of these preirradiated drugs with the cell cultures revealed no phototoxic effects.

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confidence: 99%

Photodegradation products of sulphonamide‐derived oral antidiabetics and diuretics are not phototoxic in vitro

Selvaag

Thune

1996

Photoderm Photoimm Photomed

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“…Sulphonamide itself was recognized being a photosensitizer shortly after introduction as an antibacterial in 1935 (Frank 1937;Menville and Archinard 1937;Newman and Sharlit 1937). Photosensitivity reactions due to the sulphonamide-derived thiazides chlorothiazide and hydrochlorothiazide were described shortly after their introduction for the treatment of hypertension in the 1950s (Norins 1959;Harber et al 1959).…”

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confidence: 99%

Cell cultures in the investigation of thiazide phototoxicity

Selvaag

1997

Naunyn-Schmiedeberg's Arch Pharmacol

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The NHIK 3025 cell line (Norsk Hydro Institutt for Kreftforskning), a human in situ carcinoma of the cervix cell line, was used to investigate the thiazides bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and xipamide for their potential phototoxic properties. Cell death following UVA irradiation and dependent on test substance concentration was observed in the presence of all the tested substances except chlortalidone, furosemide, indapamide and xipamide. Bendroflumethiazide was phototoxic at concentrations of 0.05 mM and higher; bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 0.25 mM and higher and butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 0.5 mM and higher.

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Erosions of the Oral Mucosa and Urticaria of the Body Following Small Doses of Sulfanilamide

Noun¹

1938

Arch Dermatol

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Dermatitis From Sulfanilamide

Cited by 32 publications

References 0 publications

Photodegradation products of sulphonamide‐derived oral antidiabetics and diuretics are not phototoxic in vitro

Photodegradation products of sulphonamide‐derived oral antidiabetics and diuretics are not phototoxic in vitro

Cell cultures in the investigation of thiazide phototoxicity

Erosions of the Oral Mucosa and Urticaria of the Body Following Small Doses of Sulfanilamide

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