Dermal granulomatous inflammation to cornified cells. Significance near cutaneous squamous cell carcinoma

Perineural granulomatous inflammation: a potential harbinger of perineural invasion in cutaneous squamous cell carcinoma

“…However, it can be seen as a foreign‐body, giant‐cell response to free keratin in the dermis, as is commonly seen in the setting of ruptured epidermoid cysts 5 . Although granulomatous inflammation has been reported in association with cSCC, in our case it was distinctive due to the perineural location 6 . It was highly suspicious that this was an ominous clue to subtle perineural invasion.…”

Hemorrhagic Foreign Body Granuloma after Cutaneous Surgery Occurring in the Setting of Aspirin Therapy or Thrombocytopenia: A Presentation of Six Cases

“…33 Also, FBG to keratin have been reported adjacent to SCCs. 34 Presumably, rupture of the pilosebaceous unit stimulates migration of polymorphonuclear leukocytes and plasma cells, contributing to granuloma formation. Cyst formation can appear as a result of scarring, trauma, or surgical pilosebaceous transsection and probably persists over time.…”

Transplantation analyses of the immunogenicity of epidermal tumors generated in murine skin two-stage carcinogenesis protocols

“…It is conceivable that the pro-inflammatory properties of cornified material [19] may have contributed to the rejection of papilloma transplants in immune-competent SSIN mice. However, the low percentage of tumor takes in immune-suppressed or immune-deficient mice suggests that most of the papillomas were not tumorigenic.…”

“…Histological analyses revealed that most of the tumors failed to establish a vasculature, collapsed, and were quickly infiltrated by monocytes and rejected in a classic foreign body reaction (data not shown). The probable presence of cornified material in the transplant, which is very proinflammatory [19], may have catalyzed or accelerated the processes of immune cell recruitment and infiltration.…”