Dermabrasion for the Treatment of Xeroderma Pigmentosum

Rare occurrence of coexistent squamous cell carcinoma and basal cell carcinoma in a case of Xeroderma Pigmentosum

“…Chemoprohylaxis with systemic retinoids, topical T4 endonuclease V, 5 Fluorouracil and imiquimod significantly reduce the rate of new cutaneous malignancies in Xeroderma Pigmentosum. [9,10,11] Dermabrasion is another effective modality, as reported by König A et al [12] Awareness about this rare condition and prevention of ultraviolet rays induced skin damage should be propagated. Genetic counselling with emphasis on implications of consanguineous marriage plays a key role in its prevention.…”

Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy

“…Although our model addressed BCC carcinogenesis for simplicity, it is expected that addressing chronic sun damage may have more profound effects on SCCs and actinic keratoses given the stronger epidemiological link. In xeroderma pigmentosum, a genetic disease related to defective DNA repair in response to UV exposure, dermabrasion of the epidermis has been reported to protect from SCCs ( 35 , 36 ). Overall, these findings strongly support the reduction of the mutation load as a potential mechanism for the effect of epidermal ablation on skin cancer occurrence.…”

Xeroderma Pigmentosum: Man Deprived of His Right to Light

“…Large areas of affected skin in patients with XP have reportedly been treated with dermatome shaving or dermabrasion [45]. Dermabrasion and isotretinoin therapies do not correct the underlying defect (DNA damage) and long-term therapy with dermabrasion, therefore, is neither ideal nor convenient.…”