Derivatives of hydroxylamine

Markova, Yu. V.; Makeeva, O. O.; Ostroumova, N. G.; Lebedeva, V. I.; Shchukina, M. N.; Pershin, G. N.

doi:10.1007/bf00759766

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2002

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“…They are also capable of competing as siderophores for iron-(III) [9][10][11]. In the biomedical sciences, hydroxamic acids moieties are used in the design of therapeutics targeting cancer [12][13][14][15], cardiovascular diseases [16,17], HIV [18,19], Alzheimer's [20,21], malaria [22][23][24][25][26][27], allergic diseases [28][29][30], tuberculosis [31][32][33][34][35][36], metal poisoning [37][38][39][40], and ironoverload [41][42][43]. In addition, the hydroxamic acids have been employed as insecticides [44,45], antimicrobials [46][47][48][49][50][51][52][53], and plant growth regulators [54][55][56]…”

Section: Introductionmentioning

confidence: 99%

Hydroxamic Acids as Pharmacological Agents

Muri¹,

Nieto²,

Sindelar³

et al. 2002

CMC

232

149

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A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.

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