Derivatives of Graphene Oxide as Potential Drug Carriers

Kozik, Violetta; Bąk, Andrzej; Pentak, Danuta; Hachuła, Barbara; Pytlakowska, Katarzyna; Rojkiewicz, Marcin; Jampílek, Josef; Sieroń, Karolina; Jazowiecka-Rakus, Joanna; Sochanik, Aleksander

doi:10.1166/jnn.2019.15855

Cited by 18 publications

(18 citation statements)

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“…Given the benzene structure of the hexagonal components of the lattice, it can be considered a huge aromatic poly molecule or intact GR, where π-π and hydrophobic forces are the main source of drug binding, however, for other forms of GR, the presence of functional groups provides more possible interactions. Because of this, the use of non-functionalized GR in biomedical applications is limited and other forms based on GR are used [127]. The unstable structure, negative charge, and poor cellular uptake of genes make the usage of a carrier necessary for their protection and transport.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Targeted drug delivery can improve the bioavailability, biocompatibility, and safety of therapeutic agents [104,105,123,124,126,128]. This can help solve the problems connected with the treatment of cancer, by reducing the systemic "intrinsic" toxicity of the drug itself (which is a limitation factor of therapy, due to the size of the dose) and, in such a way, overcome undesired side effects [104,105,123,127]. DDSs can also help to overcome the resistance of the cells to the drug [92,104,105,123].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Section: Drug Delivery Systemsmentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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“…The drug delivery systems can control the drug release in vivo and increase performance encapsulation and absorption 26,27 . Nanomaterial-based drug delivery systems have π − π stacking interactions or covalent crosslinking with drug molecules due to their small size [28][29][30][31] . Graphene, as a member of nanomaterials with a two-dimensional structure with strong π − π stacking bond 32 , has unique physical, chemical and optical properties.…”

Section: Introductionmentioning

confidence: 99%

Chloroquine drug and Graphene complex for treatment of COVID-19

Mohammadi

Esmailpour

Mohammadi

2020

Preprint

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This paper is a new step in helping the treatment of coronavirus by improving the performance of chloroquine drug. For this purpose, we propose a complex of chloroquine drug with graphene nanoribbon (GNR) scheme. We compute the structural and electrical properties and absorption of chloroquine (C18H26ClN3) and GNR complex using the density functional theory (DFT) method. By creating a drug and GNR complex, the density of states of electrons increases and the energy gap decreases compared to the chloroquine. Also, using absorption calculations and spectrums such as infrared and UV-Vis spectra, we showed that GNR is a suitable structure for creating chloroquine drug complex. Our results show that the dipole moment, global softness and electrophilicity for the drug complex increases compared to the non-complex state. Our calculations can be useful for increasing performance and reducing the side effects of chloroquine, and thus can be effective in treating coronavirus.

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“…In view of these advantages, nanocarriers including nanoparticles, vesicles, nanosheets, and nanocapsules have been intensively investigated in the biomedical field [1][2][3][4][5][6][7][8][9]. As a member of the nanocarrier, graphene oxide (GO) was also focused in the biomedical field on account of the large specific surface area, mechanical properties, and very high aspect ratio [4,[10][11][12][13][14][15]. Especially, the π-conjugated structure of GO could conjugate with a number of drug molecules either through π − π stacking interaction or through chemical covalent crosslinking [4,[10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…As a member of the nanocarrier, graphene oxide (GO) was also focused in the biomedical field on account of the large specific surface area, mechanical properties, and very high aspect ratio [4,[10][11][12][13][14][15]. Especially, the π-conjugated structure of GO could conjugate with a number of drug molecules either through π − π stacking interaction or through chemical covalent crosslinking [4,[10][11][12][13][14][15]. However, pure GO lacks a bioactive site to support cell growth, which restricted its application in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

Functional Graphene Oxide Nanocarriers for Drug Delivery

Mao

et al. 2019

International Journal of Polymer Science

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The family of graphene has attracted increasing attention on account of their large specific surface area and good mechanical properties in the biomedical field. However, some characteristics like targeted delivery property and drug delivery capacity could not satisfy the need of a drug carrier. Herein, a graphene oxide (GO) nanocarrier was designed by modification of a folic acid (FA) derivative and a β-cyclodextrin (β-CD) derivative in order to improve two properties, respectively. In the first step, reactive or crosslinkable FA and aldehydic β-CD (β-CD-CHO) were designed and synthesized for further modification. In the second step, synthesized functional molecules were coupled onto GO sheets one by one to obtain the GO nanocarrier. IR spectra and XRD results were used to identify the chemical and structural information before and after modification for the GO nanocarrier. The final GO nanocarrier exhibited a typical thin wrinkled sheet morphology of the GO sheet without any influence by two functional molecules. Finally, in vitro evaluation was used to clarify the drug loading and controlling capacity of the nanocarrier as a drug delivery system. The results revealed that the GO nanocarrier had a better CPT loading capacity and showed better controllability for CPT release.

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Derivatives of Graphene Oxide as Potential Drug Carriers

Cited by 18 publications

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Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Chloroquine drug and Graphene complex for treatment of COVID-19

Functional Graphene Oxide Nanocarriers for Drug Delivery

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