2016
DOI: 10.18632/aging.101104
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Abstract: Patients with depression have an increased risk for many aging-related disorders, but the biological mechanisms underlying this link remain to be determined. Here we examined the association between depressive symptoms and leukocyte telomere length (LTL), a marker of biological aging, among 2,175 American Indians participating in the Strong Heart Family Study. Depressive symptoms were assessed by the Center for Epidemiologic Studies of Depression Scale (CES-D), which was categorized into four levels: none (< 1… Show more

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Cited by 6 publications
(4 citation statements)
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References 49 publications
(54 reference statements)
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“…In summary, the findings of our systematic review suggest that current evidence supports cross-sectional association of shorter TL and depressive disorders [11,16,18,19,23,24,[26][27][28][29][31][32][33][34][38][39][40][41][42][43][44][45][46][47]49,51,52,54,56]. However, some studies propose that complex variables related to psychological-behavioral aspects are more likely to drive this relationship than the disease itself [22,39,42,104].…”
Section: Mdd and Tlmentioning
confidence: 52%
See 1 more Smart Citation
“…In summary, the findings of our systematic review suggest that current evidence supports cross-sectional association of shorter TL and depressive disorders [11,16,18,19,23,24,[26][27][28][29][31][32][33][34][38][39][40][41][42][43][44][45][46][47]49,51,52,54,56]. However, some studies propose that complex variables related to psychological-behavioral aspects are more likely to drive this relationship than the disease itself [22,39,42,104].…”
Section: Mdd and Tlmentioning
confidence: 52%
“…Study designs included 20 case-control studies, 14 cross-sectional studies, and 8 longitudinal studies. Twenty-nine studies (91,095 patients) reported a negative association between TL and depression [16,18,19,[23][24][25][26][27][28][29][31][32][33][34]38,[40][41][42][43][44][45][46][47][48][49][52][53][54][55][56]. Nine studies (5188 patients) did not observe association of TL and depressive disorder [11,17,20,21,30,35,37].…”
Section: Telomere Length and Depressive Disordersmentioning
confidence: 99%
“…Family Study, women had elevated rates of severe depressive symptoms (15.5%) compared to men (7.2%) (Zhao et al, 2016).…”
mentioning
confidence: 91%
“…Some studies have revealed gender‐related disparities in depressive symptoms, with women experiencing greater severity than men. For example, among American Indians in the Strong Heart Family Study, women had elevated rates of severe depressive symptoms (15.5%) compared to men (7.2%) (Zhao et al, 2016). Because few available published study results rely on population‐based measures, estimates of depression prevalence in the American Indian population remain widely unexplored and—due to the immense diversity among tribal nations—have limited generalizability.…”
Section: Introductionmentioning
confidence: 99%