volume 30, issue 1, P75-82 2012
DOI: 10.3233/jad-2012-112009
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Abstract: Objective To examine whether late-life depression, including depressive symptoms and antidepressant use, was associated with smaller total brain volume, smaller hippocampal volume, and larger white matter hyperintensity volume in a large community-based cohort of old persons without dementia. Methods Within the Washington/Hamilton Height-Inwood Columbia Aging Project (WHICAP), a community-based cohort study in northern Manhattan, 630 persons without dementia (mean age 80 years, SD=5) had volumetric measure…

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