Depression symptoms and lost productivity in chronic rhinosinusitis

Campbell, Adam P.; Phillips, Katie; Hoehle, Lloyd P.; Feng, Allen L.; Bergmark, Regan W.; Caradonna, David S.; Gray, Stacey T.; Sedaghat, Ahmad R.

doi:10.1016/j.anai.2016.12.012

Cited by 64 publications

(68 citation statements)

References 30 publications

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“…The burden of extranasal symptoms of CRS, particularly those related to poor sleep and ear/facial discomfort, is the dominant driver of decreased general health‒related QOL in CRS patients, which was found to be the case in allergic rhinitis patients as well . Moreover, emotional symptoms—particularly those related to depressed mood—associated with CRS are the most dominant factors associated with lost productivity, a finding also shown in allergic rhinitis patients . Depressed mood in CRS is also an important modulator of how patients translate overall CRS symptom burden to decreased QOL .…”

Section: Discussionmentioning

confidence: 93%

Determinants of noticeable symptom improvement despite sub‐MCID change in SNOT‐22 score after treatment for chronic rhinosinusitis

Phillips

Hoehle

Caradonna

et al. 2018

Int Forum Allergy Rhinol

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Background:The minimal clinically important difference (MCID) of the 22-item Sino-Nasal Outcome Test (SNOT-22) is specific but not sensitive for identifying patients experiencing noticeable improvement in symptoms of chronic rhinosinusitis (CRS). It is unclear why some patients with less than 1 MCID change in SNOT-22 score nevertheless report noticeable improvement in their CRS symptoms. Methods:This investigation was a retrospective study of 247 CRS patients undergoing medical management who completed SNOT-22 surveys in 2 consecutive visits 2-12 months apart. The validated nasal, sleep, ear/facial discomfort, and emotional SNOT-22 subdomain scores were calculated. At the second visit, patients reported their global change in CRS symptoms on a 5-item transition rating scale as: "Much worse"; "A li le worse"; "About the same"; "A li le be er"; or "Much be er." Patient-reported improvement in symptoms (at least "A li le be er") was tested for association with changes in SNOT-22 subdomain scores. Results:In the entire cohort, patient-reported improvement in CRS symptoms was associated with improvement in all SNOT-22 subdomain scores (p < 0.001). In patients with less than 1 MCID (12 points) of change in the SNOT-22, only the nasal subdomain (adjusted odds ratio, 0.89; 95% confidence interval [CI], 0.79-0.99; p = 0.042) was associated with patient-reported improvement in CRS symptoms. Changes in none of the other SNOT-22 subdomain scores were associated with patientreported improvement in CRS symptoms. Conclusions:Among patients with less than 1 MCID change in the SNOT-22, improvement in only nasal symptoms-but not extranasal symptoms-of CRS is associated with those who nevertheless report improvement of their CRS symptoms. C 2018 ARS-AAOA, LLC. How to Cite this Article:Phillips KM, Hoehle LP, Caradonna DS, Gray ST, Sedaghat AR. Determinants of noticeable symptom improvement despite sub-MCID change in SNOT-22 score a er treatment for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019;9:508-513.

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Section: Discussionmentioning

confidence: 93%

Determinants of noticeable symptom improvement despite sub‐MCID change in SNOT‐22 score after treatment for chronic rhinosinusitis

Phillips

Hoehle

Caradonna

et al. 2018

Int Forum Allergy Rhinol

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“…Chronic rhinosinusitis (CRS) is an inflammatory disorder of the paranasal sinuses that is highly prevalent, affecting up to 10% of the population in North America and Europe, and leads to billions of dollars in expenses annually . CRS impacts patients by reducing quality of life and reducing productivity through chronic symptomatology, acute sinonasal exacerbations and exacerbations of comorbid pulmonary disease . Because the primary impact of CRS is on patients’ lives and functionality, clinical decision‐making is most frequently based on patient‐reported outcome measures.…”

Section: Introductionmentioning

confidence: 99%

Minimal clinically important difference for the 22‐item Sinonasal Outcome Test in medically managed patients with chronic rhinosinusitis

Phillips

Hoehle

Caradonna

et al. 2018

Clinical Otolaryngology

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102

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“…All participants completed a 22‐item Sino‐Nasal Outcomes Test (SNOT‐22) survey to measure CRS symptom severity. To evaluate productivity loss that was due to CRS, participants were asked how many days of work or school were missed in the last 3 months specifically due to CRS . We chose this method of evaluating absenteeism because prior studies have validated this method of assessing disease‐related missed days of work and school …”

Section: Methodsmentioning

confidence: 99%

Smoking: An independent risk factor for lost productivity in chronic rhinosinusitis

et al. 2017

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Depression symptoms and lost productivity in chronic rhinosinusitis

Cited by 64 publications

References 30 publications

Determinants of noticeable symptom improvement despite sub‐MCID change in SNOT‐22 score after treatment for chronic rhinosinusitis

Determinants of noticeable symptom improvement despite sub‐MCID change in SNOT‐22 score after treatment for chronic rhinosinusitis

Minimal clinically important difference for the 22‐item Sinonasal Outcome Test in medically managed patients with chronic rhinosinusitis

Smoking: An independent risk factor for lost productivity in chronic rhinosinusitis

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