Depression Is Unrelated to Conversion to Dementia in Patients With Mild Cognitive Impairment

Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging

“…However, in this study a clinical diagnosis of depressive disorder was carried out, and the subjects were from a community general hospital and not from a population-based study. Furthermore, the results of the present report confirmed those of a recent study in which MCI patients who had concurrent depression did not have an increased risk of AD over two years compared to non-depressed MCI patients (Rozzini et al, 2005). Furthermore, we failed to find in this population a possible role of vascular risk factors on the depressive symptoms/dementia relationship.…”

Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging

“…However, in this study a clinical diagnosis of depressive disorder was carried out, and the subjects were from a community general hospital and not from a population-based study. Furthermore, the results of the present report confirmed those of a recent study in which MCI patients who had concurrent depression did not have an increased risk of AD over two years compared to non-depressed MCI patients (Rozzini et al, 2005). Furthermore, we failed to find in this population a possible role of vascular risk factors on the depressive symptoms/dementia relationship.…”

Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study

“…Previous studies on the predictive accuracy of affective symptoms for AD in subjects with MCI mainly focused on depressive symptoms. The outcomes of our study are consistent with some of these studies (Rozzini et al 2005; Liu et al 2007), but in disagreement with others (Modrego & Ferrandez, 2004; Gabryelewicz et al 2007). We found that depressive symptoms were only associated with a reduced risk in subjects without amnestic MCI.…”

Progression from mild cognitive impairment to dementia: A 3-year longitudinal study

“…It is unlikely that the issue could be simply attributed to statistical power: the current study, for example, involved a larger sample size and longer follow-up period than other studies that found depression was a significant predictor (Modrego and Ferrández, 2004;Palmer et al, 2007;Teng et al, 2007). The findings from the current study are nevertheless consistent with other research which found that depression does not predict progression to dementia (Brodaty et al, 2012;Rozzini et al, 2005). One possible explanation is that depression may reflect patients' levels of cognitive decline, which in turn is a robust predictor of progression to dementia.…”

Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging

“…However, in this study a clinical diagnosis of depressive disorder was carried out, and the subjects were from a community general hospital and not from a population-based study. Furthermore, the results of the present report confirmed those of a recent study in which MCI patients who had concurrent depression did not have an increased risk of AD over two years compared to non-depressed MCI patients (Rozzini et al, 2005). Furthermore, we failed to find in this population a possible role of vascular risk factors on the depressive symptoms/dementia relationship.…”

Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study

“…Previous studies on the predictive accuracy of affective symptoms for AD in subjects with MCI mainly focused on depressive symptoms. The outcomes of our study are consistent with some of these studies (Rozzini et al 2005; Liu et al 2007), but in disagreement with others (Modrego & Ferrandez, 2004; Gabryelewicz et al 2007). We found that depressive symptoms were only associated with a reduced risk in subjects without amnestic MCI.…”

Progression from mild cognitive impairment to dementia: A 3-year longitudinal study

“…It is unlikely that the issue could be simply attributed to statistical power: the current study, for example, involved a larger sample size and longer follow-up period than other studies that found depression was a significant predictor (Modrego and Ferrández, 2004;Palmer et al, 2007;Teng et al, 2007). The findings from the current study are nevertheless consistent with other research which found that depression does not predict progression to dementia (Brodaty et al, 2012;Rozzini et al, 2005). One possible explanation is that depression may reflect patients' levels of cognitive decline, which in turn is a robust predictor of progression to dementia.…”

Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging

“…However, in this study a clinical diagnosis of depressive disorder was carried out, and the subjects were from a community general hospital and not from a population-based study. Furthermore, the results of the present report confirmed those of a recent study in which MCI patients who had concurrent depression did not have an increased risk of AD over two years compared to non-depressed MCI patients (Rozzini et al, 2005). Furthermore, we failed to find in this population a possible role of vascular risk factors on the depressive symptoms/dementia relationship.…”

Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study

“…Previous studies on the predictive accuracy of affective symptoms for AD in subjects with MCI mainly focused on depressive symptoms. The outcomes of our study are consistent with some of these studies (Rozzini et al 2005; Liu et al 2007), but in disagreement with others (Modrego & Ferrandez, 2004; Gabryelewicz et al 2007). We found that depressive symptoms were only associated with a reduced risk in subjects without amnestic MCI.…”

Progression from mild cognitive impairment to dementia: A 3-year longitudinal study

“…It is unlikely that the issue could be simply attributed to statistical power: the current study, for example, involved a larger sample size and longer follow-up period than other studies that found depression was a significant predictor (Modrego and Ferrández, 2004;Palmer et al, 2007;Teng et al, 2007). The findings from the current study are nevertheless consistent with other research which found that depression does not predict progression to dementia (Brodaty et al, 2012;Rozzini et al, 2005). One possible explanation is that depression may reflect patients' levels of cognitive decline, which in turn is a robust predictor of progression to dementia.…”