Depression in later life: three etiologically different subgroups

Depressive symptoms in later life: differential impact of social support and motivational processes on depression in individuals with and without cognitive impairment

“…Cervilla and Prince (1997) suggest two different pathways lead to depression in older adults: social distress and cerebral deterioration clinically expressed as cognitive impairment. Other studies have shown etiologically different subtypes of depression in later life (Dillon et al 2009;Van den Berg et al 2001), suggesting that depression in cognitively impaired individuals is determined by other factors than depression in cognitively unimpaired individuals. Based on these findings, it can be argued that the impact of social support on depression is attenuated by cerebral deterioration in cognitively impaired individuals, as depression might be a side effect of brain degeneration (Dillon et al 2009).…”

Cerebrovascular risk factors and subsequent depression in older general practice patients

“…This categorization was based on the most commonly employed cut-off points, i.e., 50 and 60 years of age, to define late-onset depression (Van den Berg et al, 2001). To investigate whether there existed a different relationship between having any CVRF and subsequent depression for the three age at depression onset groups, an interaction term of any CVRF and age at depression onset group was added to the multivariate model.…”

“…Replication is needed to exclude the possibility that our findings were substantially influenced by biases inherent to relying on morbidity data recorded by GPs. Ideally, such future research should take into account several other variables that appear to moderate the association of CVRFs with later-life depression, including executive functioning (Mast et al, 2004c), severe life stress preceding onset of depression (Holley et al, 2006;Van den Berg et al, 2001) and physical symptoms and limitations . Ultimately, subgroups of patients could be identified for whom the vascular depression concept is particularly relevant, which, in turn, may guide prevention of depression in later life through modification of CVRFs.…”

Alzheimer's Disease and Current Approaches in its Treatment: Review

“…57,58 Yaşlılık depresyonlarında bireyin gençlik yıllarında depresyon öyküsü-nün öğrenilmesi son derece önemlidir. Heterojen profile sahip yaşlılık depresyonlarının, öykü ve stres faktörleri ile ilişkileri değerlendirildiğinde etiyolojik açıdan üç farklı gruba ayrılmaktadır: 59,60 1. Erken yaşta başlamış olup ileri yaşlarda süren depresyon, 2.…”