2013
DOI: 10.1371/journal.pone.0057058
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Abstract: ObjectiveTo examine the association between depression and all-cause and cardiovascular mortality in people with diabetes by systematically reviewing the literature and carrying out a meta-analysis of relevant longitudinal studies.Research Design and MethodsPUBMED and PSYCINFO were searched for articles assessing mortality risk associated with depression in diabetes up until August 16, 2012. The pooled hazard ratios were calculated using random-effects models.ResultsSixteen studies met the inclusion criteria, … Show more

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Cited by 348 publications
(234 citation statements)
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References 48 publications
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“…[1][2][3] Arter ial stiffening may cause damage to the cerebral vasculature, which is characterized by low impedance, as it increases pressure and flow pulsatility, which are harmful to the cerebral microcirculation. 4 The vascular depression hypothesis states that the accumulation of (micro)vascular damage in the frontal-subcortical mood regulatory circuit of the brain may ultimately cause depression.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] Arter ial stiffening may cause damage to the cerebral vasculature, which is characterized by low impedance, as it increases pressure and flow pulsatility, which are harmful to the cerebral microcirculation. 4 The vascular depression hypothesis states that the accumulation of (micro)vascular damage in the frontal-subcortical mood regulatory circuit of the brain may ultimately cause depression.…”
Section: Introductionmentioning
confidence: 99%
“…Longitudinal studies have also shown that depressed people with diabetes have a higher risk of developing microvascular and macrovascular complications and have higher mortality rates [8,9]. The mechanisms that link depression and poor outcomes in diabetes are still unclear and understudied, particularly in people with type 1 diabetes.…”
Section: Mechanisms Associated With Depression and Poor Diabetic Outcmentioning
confidence: 99%
“…Diabetes and coexisting depression have higher all-cause mortality relative to non-depressive diabetic patients [4]. End-organ damage resulting from macrovascular and microvascular complications is a common cause of death among these populations with ischemic heart disease being the most common underlying cause of death.…”
Section: Negative Effects Of Depression On Patient Lifestylementioning
confidence: 99%
“…Other variables contributing to depression may be in the form of numerous hospitalizations or other systemic conditions secondary to diabetes. In a recent study, depression alone was associated with increased risk for all-cause mortality with a specific 1.5 fold increase in mortality for diabetics [4]. Meta-analysis of 24 studies has established that depression is associated with hyperglycemia and a poor glycemic control [5].…”
Section: Introductionmentioning
confidence: 99%