Depression and Risk of Incident Asthma in Adults. The CARDIA Study

Brunner, Wendy; Schreiner, Pamela J.; Sood, Anil K.; Jacobs, David R.

doi:10.1164/rccm.201307-1349oc

Cited by 58 publications

(53 citation statements)

References 51 publications

(52 reference statements)

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“…A recent longitudinal study showed that depression (defined as a Center for Epidemiologic Studies Depression (CESD) scale score ≥16 and/or self-reported use of antidepressant medications) is associated with 1.26 times higher risk of incident (new-onset) asthma among U.S. white and African American adults (95% confidence interval for hazard ratio= 1.02 to 1.56) 25 . In another longitudinal study, African American women with a CESD scale score ≥33 had twice the risk of incident asthma as those with a CESD scale score <16 (which suggests no significant depression) 26 .…”

Section: Discussionmentioning

confidence: 99%

Depression, Asthma, and Bronchodilator Response in a Nationwide Study of US Adults

Han

Forno

Marsland

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

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Background Little is known about the relation between two common co-morbidities (depression and anxiety) and asthma or bronchodilator response (BDR). Objective To examine the association between depressive symptoms and asthma or BDR in U.S. adults. Methods Cross-sectional study of 20,272 adults 20–79 years from the 2007–2012 National Health and Nutrition Examination Survey. Depressive symptoms were measured using the Patient Health Questionnaire (PHQ-9), and classified as: none to minimal, mild, moderate, moderately severe, and severe. Major depression (comprising moderately severe to severe symptoms) was defined as a PHQ-9 ≥15. Anxiety was defined as ≥5 days feeling anxious in the prior month. Current asthma was defined as having been diagnosed with asthma by a doctor or health professional and ≥1 asthma attack in the previous year. BDR (as percentage of baseline FEV1) was measured in 1,356 participants with FEV1/FVC<0.70 and/or FEV1<70% of predicted. Logistic or linear regression was used for the multivariable analysis. Results Depressive symptoms were significantly and linearly associated with asthma, independently of anxiety symptoms. Subjects with major depression had 3.4 higher odds of asthma than those with minimal or no depressive symptoms (95% confidence interval 2.6–4.5, P<0.01). Among adults with asthma, major depression was associated with a 4.2% reduction in BDR (95% CI=−7.5% to −0.8%, P=0.02). Major depression was not associated with BDR among adults without asthma. Anxiety was not associated with asthma or BDR. Conclusion Depressive symptoms are associated with asthma in adults, independently of anxiety symptoms. Major depression is associated with reduced BDR in adults with asthma.

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Section: Discussionmentioning

confidence: 99%

Depression, Asthma, and Bronchodilator Response in a Nationwide Study of US Adults

Han

Forno

Marsland

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

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“…As previously noted, a number of studies have documented fairly strong and consistent associations between reports of discriminatory treatment and depressive symptoms, as well as major depressive disorder (Barnes et al 2004, Brown et al 2000, Gee et al 2007, Lau et al 2013, McLaughlin et al 2010). Both major depression and elevated depressive symptoms have been implicated in the development of a wide range of clinical disease outcomes including, but not limited to, cardiovascular disease (Henderson et al 2013, Vaccarino et al 2007, Whooley & Wong 2013), diabetes (Golden et al 2008, Holt et al 2014), HIV (Ickovics et al 2001), and asthma (Brunner et al 2014, Coogan et al 2014b). Depression and elevated depressive symptoms have also been linked to several important health behaviors such as smoking (Breslau et al 1998), inadequate physical activity (Roshanaei-Moghaddam et al 2009), and sleep (Hall et al 2000, Tsuno et al 2005).…”

Section: Ongoing Controversies and Gaps In Knowledgementioning

confidence: 99%

Self-Reported Experiences of Discrimination and Health: Scientific Advances, Ongoing Controversies, and Emerging Issues

Lewis

Cogburn

Williams

2015

Annu. Rev. Clin. Psychol.

782

770

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Over the past two decades, research examining the impact of self-reported experiences of discrimination on mental and physical health has increased dramatically. Studies have found consistent associations between exposure to discrimination and a wide range of DSM-diagnosed mental disorders, as well as objective physical health outcomes. Associations are seen in cross-sectional as well as longitudinal studies and persist even after adjustment for controls, including personality characteristics and other threats to validity. However, controversies remain, particularly around the best approach to measuring experiences of discrimination; the significance of racial/ethnic discrimination versus overall mistreatment; the need to account for “intersectionalities”; and the importance of comprehensive assessments. These issues are discussed in detail, along with emerging areas of emphasis including: cyber-discrimination; anticipatory stress or vigilance around discrimination; and interventions with potential to reduce the negative effects of discrimination on health. We also discuss priorities for future research, and implications for interventions and policy.

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“…It is the most common chronic respiratory disease in adults worldwide with a prevalence of 4-8% [1,2]. Adults with asthma have twice as high risk of also having depression or anxiety compared to the general population [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Asthma and affective traits in adults: a genetically informative study

Lehto

Pedersen

Almqvist³

et al. 2019

Preprint

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Depression, anxiety and high neuroticism (affective traits) are often comorbid with asthma. A causal direction between the affective traits and asthma is difficult to determine, however, it may be that there is a common underlying pathway attributable to shared genetic factors. Our aim was to determine whether a common genetic susceptibility exists for asthma and each of the affective traits.An adult twin cohort from the Swedish Twin Register underwent questionnaire-based health assessments (n=23 693) and genotyping (n=15 908). Firstly, questionnaire-based associations between asthma and affective traits were explored. This was followed by genetic analyses: a) polygenic risk scores (PRS) for affective traits were used as predictors of asthma, and b) linkage-disequilibrium score regression based on genome-wide association results from UK Biobank was used to quantify genetic correlations.Analyses found that the questionnaire-based associations between asthma and each affective trait were associated (OR 1.7, 95%CI 1.5-1.9 major depression, OR 1.5, 95%CI 1.3-1.6 anxiety, and OR 1.6, 95% 1.4-1.8 high neuroticism). Genetic susceptibility for neuroticism explained the variance in asthma with a dose response effect; that is, those in the highest neuroticism PRS quartile were more likely to have asthma than those in the lowest quartile (OR 1.4, 95%CI 1.2-1.6). Genetic correlations were found between depression and asthma (rg= 0.17), but not for anxiety or neuroticism score.We conclude that the observed comorbidity between asthma and the affective traits may in part be due to shared genetic influences between asthma and depression and neuroticism, but not anxiety.

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Depression and Risk of Incident Asthma in Adults. The CARDIA Study

Cited by 58 publications

References 51 publications

Depression, Asthma, and Bronchodilator Response in a Nationwide Study of US Adults

Depression, Asthma, and Bronchodilator Response in a Nationwide Study of US Adults

Self-Reported Experiences of Discrimination and Health: Scientific Advances, Ongoing Controversies, and Emerging Issues

Asthma and affective traits in adults: a genetically informative study

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