Depression and heart disease: What do we know, and where are we headed?

Pozuelo, Leo; Tesar, George; Zhang, Jianping; Penn, Marc S.; Franco, Kathleen; Jiang, Wei

doi:10.3949/ccjm.75a.08011

Cited by 71 publications

(88 citation statements)

References 139 publications

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“…7 Studi INTERHEART di 52 negara didapatkan faktorfaktor psikososial, antara lain stres dan depresi merupakan faktor risiko infark miokardium 32,5%. [8][9][10] Untuk mengurangi risiko gangguan kardiovaskular itu diperlukan pemeriksaan dini fungsi endotel.…”

Section: 2unclassified

Deteksi Disfungsi Endotel pada Gangguan Depresi Mayor dengan Pengukuran <i>Endothelial-Dependent Flow-Mediated Vasodilatation<i>

Wulandari

Purnomowati

Wahmurti

2017

GMHC

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AbstrakGangguan depresi mayor ialah salah satu gangguan jiwa yang mengganggu fungsi kehidupan dan sebagai salah satu penyebab terbesar disabilitas di seluruh dunia termasuk masalah kesehatan masyarakat, baik dalam segi sosial, ekonomi, maupun klinis. Depresi memicu disfungsi endotel yang merupakan proses awal gangguan kardiovaskular dan menjadi faktor risiko independen penyakit jantung koroner. Deteksi disfungsi endotel pada pasien gangguan depresi mayor diharapkan dapat menunjang penatalaksanaan yang komprehensif dan menurunkan risiko gangguan kardiovaskular. Tujuan penelitian mengetahui disfungsi endotel pada gangguan depresi mayor dengan mengukur endothelial-dependent flow-mediated vasodilatation (FMD). Penelitian ini adalah bagian dari penelitian gangguan depresi mayor periode Maret 2015-Maret 2016. Gangguan depresi mayor ditentukan menggunakan Structured Clinical Interview for DSM-IV Axis I Disorder (SCID-I) dan Hamilton Depression Rating . Usia dan jenis kelamin subjek disesuaikan, kriteria inklusi penelitian adalah pasien memenuhi kriteria gangguan depresi mayor SCID-I, skor HDRS-17 ≥19, tekanan darah, indeks massa tubuh, profil lipid dan kadar gula darah dalam batas normal, serta tidak sedang menderita atau mempunyai riwayat penyakit kardiovaskular. Pada penelitian ini dilakukan pemeriksaan terhadap 15 pasien dari RS Dustira dan RS Salamun yang memenuhi kriteria inklusi dan 15 partisipan sehat. Deteksi disfungsi endotel noninvasif digunakan alat ultrasonografi resolusi tinggi pada arteri brakialis (FMD) yang menggambarkan fungsi vasodilatasi yang endotel-dependen. Pemeriksaan FMD dilakukan di Instalasi Pelayanan Jantung RSUP Dr. Hasan Sadikin Bandung menggunakan alat ekokardiografi merek General Electric tipe Vivid 7 dan dinilai berdasar atas skoring yang berlaku. Nilai FMD pasien gangguan depresi mayor abnormal pada 11 dari 15 pasien. Nilai abnormal pada skoring FMD menunjukkan gangguan respons vasodilatasi pada pasien gangguan depresi mayor yang menggambarkan disfungsi endotel. Simpulan, FMD dapat digunakan sebagai alternatif pemeriksaan fungsi endotel yang noninvasif untuk deteksi dini proses awal gangguan fungsi pembuluh darah. Kata kunci: Disfungsi endotel, endothelium-dependent flow-mediated vasodilatation (FMD), gangguan depresi mayor Endothelial Dysfunction Detection in Major Depressive Disorder Using Endothelial-Dependent Flow-Mediated Vasodilatation Assessment AbstractMajor depressive disorder is a mental disorder that reduce people's functioned, is the leading cause of disability worldwide and a significant contributor to the global burden of disease. The global burden of depression poses a substantial public health challenge at the social, economic and clinical level. Depressive symptoms may influence the development and progression of cardiovascular diseases by fostering endothelial dysfunction. Depressive symptoms of sufficient severity can serve as independent risk factors for ischemic heart disease. Early detection of endothelial dysfunction will decrease the risk of cardiovascular disord...

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Section: 2unclassified

Deteksi Disfungsi Endotel pada Gangguan Depresi Mayor dengan Pengukuran <i>Endothelial-Dependent Flow-Mediated Vasodilatation<i>

Wulandari

Purnomowati

Wahmurti

2017

GMHC

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“…Many studies suggested that the prevalence of depression is higher among patients with CHD compared to people without CHD [1][2][3][4]. However, a study showed that depression was not associated with developing CHD [5].…”

Section: Introductionmentioning

confidence: 99%

“…A study mentioned that depression is a risk factor for CHD and it can result in complications and death [4]. Furthermore, recent studies have shown much evidence that depression is a risk factor for developing CHD, with an approximately 2-times higher risk of death [2,3].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and Treatment of Depression and its Outcomes in Patients with Coronary Heart Disease (CHD): A Literature Review

Alalawi¹

2015

JCCR

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“…Such alterations are believed to reduce heart rate variability (HRV), a well-known prognostic risk factor for cardiovascular disease and mortality. [2] Access this article online Autonomic function assessment by HRV is relatively new and not used in clinical practice in most of the medical setups in India. Very few studies have been carried out to assess cardiac autonomic functions in depressed patients in Indian population.…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic dysfunction assessed by heart rate variability in major depression

Dubey¹,

Sawane²

2017

Int J Med Sci Public Health

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Depression and heart disease: What do we know, and where are we headed?

Cited by 71 publications

References 139 publications

Deteksi Disfungsi Endotel pada Gangguan Depresi Mayor dengan Pengukuran <i>Endothelial-Dependent Flow-Mediated Vasodilatation<i>

Deteksi Disfungsi Endotel pada Gangguan Depresi Mayor dengan Pengukuran <i>Endothelial-Dependent Flow-Mediated Vasodilatation<i>

Diagnosis and Treatment of Depression and its Outcomes in Patients with Coronary Heart Disease (CHD): A Literature Review

Cardiac autonomic dysfunction assessed by heart rate variability in major depression

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