Depression and anxiety are associated with poor outcomes in patients with inflammatory bowel disease: A nationwide population-based cohort study in South Korea

Kim, Seulji; Lee, Seung-Woo; Koh, Seong‐Joon; Im, Jong Pil; Kim, Sang Woo; Lee, Hyun Jung

doi:10.1016/j.genhosppsych.2023.01.015

Cited by 4 publications

(13 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The included 24 studies, including 14 cohort 21,22,[24][25][26][27][28][29]31,34,37,38,40,44 and 10 case-control studies, 23,30,32,33,35,36,39,[41][42][43] met the eligibility criteria for this systematic review investigating the impact of depression on prognosis in IBD. These studies were published from 2000 to 2023, with a total of 630 408 IBD patients, of which 16 studies' 21,23,25,26,[28][29][30][31][37][38][39][40][41][42][43][44] follow-up time were ≥1 year. The included studies were from four continents, including 12 countries, with the most from the United States (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies reported on patients with UC exclusively 32,41,43,44 ; three reported on patients with CD exclusively 34,38,42 ; 10 studies reported on patients with IBD exclusively 24,[26][27][28]30,31,36,37,39,40 ; four reported on patients with UC and CD, respectively 22,29,33,35 ; three reported on patients with UC, CD, and IBD respectively. 21,23,25 Therefore, when data reported for meta-analysis, seven studies [21][22][23]25,29,33,35 were entered as two or three studies. Five studies reported on patients restricted in remission at baseline.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review and meta‐analysis: Impact of depression on prognosis in inflammatory bowel disease

Ji,

Li,

Dai

et al. 2024

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and AimDepression is highly prevalent in patients with inflammatory bowel disease (IBD), which may affect the prognosis of IBD. This aimed to investigate the impact of depression on prognosis in IBD.MethodsA systematic literature search was performed in four databases (Medline, Embase, Web of Science, and PsycINFO) up to December 31, 2023. Studies were included if they investigated the impact of depression on prognosis in IBD. The primary outcome was flare in IBD, and secondary outcomes were hospitalization, readmission, emergency visits, surgery, and escalation of medical therapy. Relative risks (RRs) were utilized to estimate the risk in each of the above prognostic indicators.ResultsFourteen cohort and 10 case–control studies matched our entry criteria, comprising 630 408 patients with IBD. Twenty‐two of included studies were considered to have a low risk of bias. Depression was found to significantly increase the risk of flare (RR = 1.37, 95% CI 1.16–1.63), hospitalization (RR = 1.11, 95% CI 1.00–1.23), readmission (RR = 1.32, 95% CI 1.04–1.67), emergency visits (RR = 1.33, 95% CI 1.12–1.59), surgery (1.38, 95% CI 1.08–1.76), and escalation of medical therapy (RR = 1.38, 95% CI 1.13–1.69) in IBD. Of note, patients with depression in ulcerative colitis had significant differences in readmission (RR = 1.38, 95% CI 1.19–1.60) and escalation of medical therapy (RR = 1.78, 95% CI 1.55–2.04). Additionally, the association was observed in patients with Crohn's disease in terms of flare (RR = 1.47, 95% CI 1.08–2.01) and hospitalization (RR = 1.20, 95% CI 1.03–1.40).ConclusionsCurrent evidence suggested that depression could significantly increase the risk of poor prognosis worsening in patients with IBD. However, the association varied in IBD subtypes.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic review and meta‐analysis: Impact of depression on prognosis in inflammatory bowel disease

Ji,

Li,

Dai

et al. 2024

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…6 These psychological symptoms impair patient's QoL, and impact their attitudes and behaviors toward disease management and recovery, significantly contributing to an unfavorable prognosis of patients with IBD. 4,7 Furthermore, the onset of IBD is closely related to genetic background, environmental factors, dietary habits, and lifestyle. [8][9][10][11][12] In a vast and densely populated country like China, these factors may influence disease progression and QoL in patients with IBD, potentially leading to geographic disparities across different regions.…”

Section: Introductionmentioning

confidence: 99%

“…Patients with IBD have been reported to be more prone to mental distress 6 . These psychological symptoms impair patient's QoL, and impact their attitudes and behaviors toward disease management and recovery, significantly contributing to an unfavorable prognosis of patients with IBD 4,7 . Furthermore, the onset of IBD is closely related to genetic background, environmental factors, dietary habits, and lifestyle 8–12 .…”

Section: Introductionmentioning

confidence: 99%

Geographic differences in psychological symptoms, sleep quality, and quality of life in patients with inflammatory bowel disease: A multicenter study in China

Liu,

Zhang,

et al. 2024

J of Digest Diseases

View full text Add to dashboard Cite

ObjectiveWe aimed to explore the geographic differences in psychological symptoms, sleep quality, and quality of life (QoL) among adult patients with inflammatory bowel disease (IBD).MethodsA unified questionnaire was developed to collect data on psychological status and QoL of IBD patients from 42 hospitals across 22 provinces, municipalities, and autonomous regions in China's mainland from September 2021 to May 2022.ResultsA total of 2478 patients with IBD were surveyed. The proportions of patients with anxiety (28.5% vs 23.1%), depression (32.3% vs 27.8%), and poor QoL (44.8% vs 32.2%) were significantly higher in patients from the northern region compared to the southern region (all P < 0.05). In the western region, the proportions of patients with anxiety (31.9% vs 23.0%), depression (37.7% vs 26.7%), sleep disturbances (64.5% vs 58.5%), and poor QoL (44.9% vs 34.8%) were significantly higher than in the eastern and central regions (all P < 0.01). Patients from inland regions had significantly higher rates of anxiety (27.1% vs 23.3%), depression (32.5% vs 26.0%), sleep disturbance (62.0% vs 57.7%), and poor QoL (43.5% vs 29.9%) compared to those from coastal regions (all P < 0.05). In economically underdeveloped areas, the proportions of patients with depression (33.1% vs 28.5%) and poor QoL (52.0% vs 32.4%) were significantly higher than in economically (relatively) developed areas (both P < 0.05).ConclusionThere are significant geographic differences in psychological symptoms, sleep quality, and QoL among Chinese patients with IBD, which might provide valuable insights for global IBD research and clinical practice.

show abstract

“…The relationship between UC and unhealthy psychological conditions seems bidirectional. The presence of abnormal anxiety scores at the baseline was associated with the later need for glucocorticosteroids or flare of UC activity and escalation of therapy in remission UC patients (Fairbrass et al, 2021 ), and depression at the baseline was related to an increased risk of aggressive UC at clinical follow-up (Kim et al, 2023 ). Despite this, the underlying mechanisms and association between psychological stress and IBD remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

The variation characteristics of fecal microbiota in remission UC patients with anxiety and depression

Xu,

Li,

2023

Front. Microbiol.

View full text Add to dashboard Cite

BackgroundUlcerative colitis (UC) patients with relapsed disease are most likely to suffer from anxiety and depression. Increasing data indicates that psychological issues can change the composition of intestinal flora. Thus, we aim to seek the variation of intestinal microbiota composition in remission UC patients with anxiety and depression in Northwest China.ResultsIn this study, 45 UC patients in remission were enrolled. The incidence of anxiety was 33.3%, and the prevalence of depression was 22.2%. There was no statistical difference in the alpha diversity of fecal microbiota, while beta diversity had a significant difference between the anxiety group and the non-anxiety group and the depression group and the non-depression group. Species composition analysis results showed that the ratio of Bifidobacterium and Lactobacilales significantly decreased. At the same time, the proportion of Escherichia-Shigella and Proteus_mirabilis increased in the anxiety group, and the ratio of Faecalibacterium and Bifidobacterium significantly decreased. In contrast, Escherichia-Shigella increased in the depression group at the gene levels.ConclusionAnxiety and depression still exist in UC patients even in the remission period. We first identify that the proportion of probiotics decreases while the proportion of pathogens increases in UC patients with anxiety and depression. These findings may provide a new pathophysiological mechanism for the recurrence of disease caused by impaired psychological function and a new method for the treatment strategy of UC patients with psychological issues.

show abstract

Depression and anxiety are associated with poor outcomes in patients with inflammatory bowel disease: A nationwide population-based cohort study in South Korea

Cited by 4 publications

References 40 publications

Systematic review and meta‐analysis: Impact of depression on prognosis in inflammatory bowel disease

Systematic review and meta‐analysis: Impact of depression on prognosis in inflammatory bowel disease

Geographic differences in psychological symptoms, sleep quality, and quality of life in patients with inflammatory bowel disease: A multicenter study in China

The variation characteristics of fecal microbiota in remission UC patients with anxiety and depression

Contact Info

Product

Resources

About