Depression accelerates the development of gastric cancer through reactive oxygen species-activated ABL1 (Review)

Huang, Tianhe; Zhou, Fuling; Wang-Johanning, Feng; Kang, Nan; Wei, Yongchang

doi:10.3892/or.2016.5127

Cited by 33 publications

(23 citation statements)

References 86 publications

(105 reference statements)

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“…Control subjects were individually selected from the same residence town of matched case patient or from the town with similar incidence of GC , matching for sex and age (±3 years). We divided Xianyou County into three groups of region (high, middle, and low incidence area) based on the standardized mortality rate of GC that was reported in our previously study (Huang et al, 2016). Eligible controls must have also been resided in Xianyou County for at least 10 years and haven't been diagnosed with GC.…”

Section: Study Design and Study Populationmentioning

confidence: 99%

Risk Factors of Gastric Cancer in High-Risk Region of China: A Population-Based Case-control Study

Chen

Lin

Zheng³

et al. 2019

Asian Pac J Cancer Prev

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Background:The reason for the high incidence of gastric cancer (GC) in Xianyou County of China was largely unknown. We aimed to explore the potential sociodemographic risk factors and their associations to GC.Methods:A population-based case-control study was conducted during March 2013 and April 2016 in Xianyou County. All newly diagnosed patients of GC were recruited as cases, while controls were selected by matching for cases’ sex, age (± 3 years) and the place of residence.Results:A total of 523 GC cases and 523 matched healthy controls were included in the final analysis with mean age of 66.27±8.81 years for cases and 66.31±8.83 years for controls, respectively. Participants with low socioeconomic status were observed with higher GC risk compared to those in high socioeconomic status (adjusted OR=2.10, 95% CI: 1.13-3.89). Compared to those regularly drink green tea, patients did not have this dietary habit had nearly 3-fold increased GC risk (adjusted OR=2.91, 95% CI: 1.38-6.13). Other dietary habit, including consumption of hard food, omission of breakfast, consumption of pickled vegetables 30 years ago, overeating were all associated with increased risk of GC. Interaction effect were found. Patients in low socioeconomic status and skipped breakfast had 10-fold higher risk of GC compared to reference group in high socioeconomic status and eat breakfast regularly (OR=10.71, 95% CI: 5.19-22.10). Furthermore, patients in low socioeconomic status and consumed pickled vegetable 30 years ago had 6-fold higher risk of GC compared to those in high socioeconomic status but did not intake pickled vegetables 30 years ago (OR=6.11, 95% CI: 3.87-9.66).Conclusion:High incidence of GC risk in Xianyou County might be partly attributed to various sociodemographic factors. Specific prevention effort could be target on population in low socioeconomic status combined with habit of breakfast omission or intake of pickled vegetables.

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Section: Study Design and Study Populationmentioning

confidence: 99%

Risk Factors of Gastric Cancer in High-Risk Region of China: A Population-Based Case-control Study

Chen

Lin

Zheng³

et al. 2019

Asian Pac J Cancer Prev

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“…ABL1 is indirectly activated by fumarate, promotes aerobic glycolysis via activation of the mTOR-HIF1α pathway, and induces NRF2 transcription/activity, which protects cells from ROS-induced injury [73]. Moreover, ABL1 has been postulated to mediate gastric cancer development following activation by depression-induced oxidative stress [74]. Consistent with the above reports, multiple metabolic pathway genes that regulate energy metabolism are altered in MCF-7 cells expressing ABL1/ABL2-targeted siRNA [75].…”

Section: Abl Kinases Regulate Tumor Growthmentioning

confidence: 99%

Enabling Tumor Growth and Progression: Recent Progress in Unraveling the Functions of ABL Kinases in Solid Tumor Cells

2018

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Purpose of Review The goal of this review is to summarize our current knowledge regarding how ABL family kinases are activated in solid tumors and impact on solid tumor development/progression, with a focus on recent advances in the field. Recent Findings Although ABL kinases are known drivers of human leukemia, emerging data also implicates the kinases in a large number of solid tumor types where they promote diverse processes such as proliferation, survival, cytoskeletal reorganization, cellular polarity, EMT (epithelial-mesenchymal-transition), metabolic reprogramming, migration, invasion and metastasis via unique signaling pathways. ABL1 and ABL2 appear to have overlapping but also unique roles in driving these processes. In some tumor types, the kinases may act to integrate pro- and anti-proliferative and -invasive signals, and also may serve as a switch during EMT/MET (mesenchymal-epithelial) transitions. Conclusions Most data indicate that targeting ABL kinases may be effective for reducing tumor growth and preventing metastasis; however, ABL kinases also may have a tumor suppressive role in some tumor types and in some cellular contexts. Understanding the functions of ABL kinases in solid tumors is critical for developing successful clinical trials aimed at targeting ABL kinases for the treatment of solid tumors.

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“…Although several studies have demonstrated that deletion of ABL1 causes spermatogenic failure (Kharbanda et al, ), the role of ABL1 upregulation in spermatogenesis remains unclear. ABL1 has recently been reported to be activated by ROS (Huang, Zhou, Wang‐Johanning, Nan, & Wei, ), and upregulation of ABL1 promotes p53 transcriptional activity (Furlan et al, ). In addition, ABL1 is essential for the regulation of the cytoskeleton (Bradley & Koleske, ), and the cytoskeleton is vital for the transport, mitosis and meiosis of germ cells (Su, Mruk, & Cheng, ; Wen et al, ).…”

Section: Discussionmentioning

confidence: 99%

Microarray meta‐analysis identifies candidate genes for human spermatogenic arrest

Fang

Chen

et al. 2019

Andrologia

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Male infertility affects approximately half of couples who have difficulty becoming pregnant, and its prevalence is continuously rising. Many studies have been performed using animal testes to reveal the mechanisms of male infertility, but few studies have investigated human testes due to various limitations. The aim of this study was to investigate the gene expression profile of impaired human testes through a meta‐analysis of microarray data sets, which was accomplished by using 178 human testis samples and 7 microarray data sets. Impaired testes were categorised into four pathological phenotypes or the normal phenotype based on their Johnsen score. Then, a meta‐analysis was performed to screen out the differentially expressed genes (DEGs) in each phenotype. The DEGs were used in a subsequent bioinformatics analysis. Our results identified several novel hub genes and pathways and suggested that G1 mitotic cell cycle arrest was a remarkable feature in pre‐meiotic arrest. Furthermore, fifteen p53‐interacting proteins, such as ABL1 and HDAC2, whose roles in spermatogenesis have not been well characterised, were selected from the DEGs through a strict screening procedure.

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Depression accelerates the development of gastric cancer through reactive oxygen species-activated ABL1 (Review)

Cited by 33 publications

References 86 publications

Risk Factors of Gastric Cancer in High-Risk Region of China: A Population-Based Case-control Study

Risk Factors of Gastric Cancer in High-Risk Region of China: A Population-Based Case-control Study

Enabling Tumor Growth and Progression: Recent Progress in Unraveling the Functions of ABL Kinases in Solid Tumor Cells

Microarray meta‐analysis identifies candidate genes for human spermatogenic arrest

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