Depressed Patients Have Decreased Binding of Tritiated Imipramine to Platelet Serotonin 'Transporter'

Paul, Steven M.

doi:10.1001/archpsyc.1981.01780370017001

Arch Gen Psychiatry

1981

DOI: 10.1001/archpsyc.1981.01780370017001

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Depressed Patients Have Decreased Binding of Tritiated Imipramine to Platelet Serotonin 'Transporter'

Steven M. Paul¹

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Cited by 319 publications

(56 citation statements)

References 13 publications

Supporting

1

Mentioning

53

Contrasting

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“…The usefulness of this approach in human neurological and psychiatric diseases is demonstrated by specific changes of platelet SERT in epilepsy and depression [1,9,[17][18][19][20][21]. The present results strengthen the idea of a correlation between platelet and brain SERT.…”

Section: Discussionsupporting

confidence: 81%

Binding of Paroxetine to the Serotonin Transporter in Membranes from Different Cells, Subcellular Fractions and Species

Cupello

¹

,

Albano

²

,

Gatta

³

et al. 2008

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The usefulness of this approach in human neurological and psychiatric diseases is demonstrated by specific changes of platelet SERT in epilepsy and depression [1,9,[17][18][19][20][21]. The present results strengthen the idea of a correlation between platelet and brain SERT.…”

Section: Discussionsupporting

confidence: 81%

Binding of Paroxetine to the Serotonin Transporter in Membranes from Different Cells, Subcellular Fractions and Species

Cupello

¹

,

Albano

²

,

Gatta

³

et al. 2008

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…This suggests that the 3H-imipramine binding sites on the platelet membrane is a trait marker rather than a state-dependent marker of depression. Such a conclusion has also been reached by Paul et al (1981b) who showed that the number of binding sites remained decreased even after clinical recovery. To overcome the possible interference of tricyclic antidepressants with the 3H-imipramine binding, Gay etal.…”

Section: Markers Of Central Serotonin Functionmentioning

confidence: 55%

Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review

Leonard

¹

1986

Human Psychopharmacology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…This was supported by studies in India [8], USA [24], and Canada [27]. The possible justification could be the decrement of serotonin neurotransmitters in depressed prisoners [44,45] that has an impact on diminished cognitive performance and quality of sleep.…”

Section: Discussionmentioning

confidence: 80%

Poor sleep quality and associated factors among prisoners of the Diredawa correctional facility in eastern Ethiopia

Getachew

¹

,

Azale

²

,

Necho

³

2020

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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