Depressed immune function in epidermodysplasia verruciformis

Prawer, S. E.

doi:10.1001/archderm.113.4.495

Cited by 30 publications

(33 citation statements)

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“…It has been reported that blast transformation of T cells (168) and nonspecific cell-mediated immunity (68,172) are largely diminished in the majority of EV cases. Moreover, an anergy to dinitrochlorobenzene, a skin contact sensitizer, has also constantly been observed (69).…”

Section: Ever Proteins In Immune Cellsmentioning

confidence: 99%

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

Łazarczyk

Cassonnet

Pons

et al. 2009

Microbiol Mol Biol Rev

133

128

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SUMMARY Infections by human papillomaviruses (HPVs) are the most frequently occurring sexually transmitted diseases. The crucial role of genital oncogenic HPV in cervical carcinoma development is now well established. In contrast, the role of cutaneous HPV in skin cancer development remains a matter of debate. Cutaneous beta-HPV strains show an amazing ubiquity. The fact that a few oncogenic genotypes cause cancers in patients suffering from epidermodysplasia verruciformis is in sharp contrast to the unapparent course of infection in the general population. Our recent investigations revealed that a natural barrier exists in humans, which protects them against infection with these papillomaviruses. A central role in the function of this HPV-specific barrier is played by a complex of the zinc-transporting proteins EVER1, EVER2, and ZnT-1, which maintain cellular zinc homeostasis. Apparently, the deregulation of the cellular zinc balance emerges as an important step in the life cycles not only of cutaneous but also of genital HPVs, although the latter viruses have developed a mechanism by which they can break the barrier and impose a zinc imbalance. Herein, we present a previously unpublished list of the cellular partners of EVER proteins, which points to future directions concerning investigations of the mechanisms of action of the EVER/ZnT-1 complex. We also present a general overview of the pathogenesis of HPV infections, taking into account the latest discoveries regarding the role of cellular zinc homeostasis in the HPV life cycle. We propose a potential model for the mechanism of function of the anti-HPV barrier.

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Section: Ever Proteins In Immune Cellsmentioning

confidence: 99%

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

Łazarczyk

Cassonnet

Pons

et al. 2009

Microbiol Mol Biol Rev

133

128

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“…Epidermodysplasia verruciformis (EV) is one of the model diseases in which the rela tionship between human papilloma virus (HPV) infection and oncogenesis can be as sessed [5][6][7], In this autosomal recessive genodermatosis a generalized infection with HPVs results in disseminated lesions resem bling plane warts (induced by HPV-3 or HPV-10) or/and in the pityriasis versicolor like and reddish plaques (provoked by EVspecific virus types (5,8,9,12,14,15,17,(19)(20)(21)(22)(23)(24)(25) [8][9][10], Skin tumors with features of Bowen's atypia and squamous cell carcino mas develop in the patients infected with EV-specific HPVs [11,12], specifically with HPV-5 and HPV-8, usually in the light-exposed areas [5]. Moreover, decreased cellmediated immunity has been demonstrated in EV, resulting mainly in unresponsiveness to experimental sensitization to dinitrochlorobenzene (DNCB) [13][14][15][16],…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, decreased cellmediated immunity has been demonstrated in EV, resulting mainly in unresponsiveness to experimental sensitization to dinitrochlorobenzene (DNCB) [13][14][15][16],…”

Section: Introductionmentioning

confidence: 99%

Langerhans Cells in Epidermodysplasia verruciformis

Haftek¹,

Jabłońska²,

Szymańczyk³

et al. 1987

Dermatology

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T cell defect and anergy to contact sensitizers are characteristic of the depressed cell-mediated immunity in epidermodysplasia verruciformis (EV). In this disease the generalized infection with human papilloma viruses is associated with a high risk of skin cancers. Langerhans cell density was studied quantitatively in lesions and noninvolved epidermis of EV using OKT6 and anti-HLA-DR monoclonal antibodies with indirect immunofluorescence technique. No significant changes were found in apparently normal skin suggesting no primary defect of Langerhans cells in EV. A marked decrease in Langerhans cell number per unit of epidermal volume could be observed in EV lesions. This additional reduction of immunological surveillance at sites of potentially oncogenic human papilloma virus infection may contribute to the increased risk of malignant transformation in EV lesions.

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“…EV patients have impaired cell-mediated immunity (CMI) [15][16][17][18][19][20]. Decreased T-lymphocyte counts and CD4/CD8 ratios and a reduced T-cell responsiveness to mitogens were found in some patients.…”

Section: Clinical and Histologic Findingsmentioning

confidence: 99%

Genetics of Epidermodysplasia Verruciformis

Kawase¹

2013

Current Genetics in Dermatology

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Depressed immune function in epidermodysplasia verruciformis

Cited by 30 publications

References 0 publications

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

The EVER Proteins as a Natural Barrier against Papillomaviruses: a New Insight into the Pathogenesis of Human Papillomavirus Infections

Langerhans Cells in Epidermodysplasia verruciformis

Genetics of Epidermodysplasia Verruciformis

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