Depletion of intracellular Ca2+ induces FOXM1 SUMOylation and accumulation on the inner nuclear membrane and accelerates G2/M cell cycle transition

Regulation of anti-tumor immunity by metal ion in the tumor microenvironment

“…After the engagement of immunoreceptors, the mitogenic signal emanating from the IS induces the breakdown of PIP2 to inositol trisphosphate (IP3) binding to the IP3 receptors resulting in the release of Ca 2+ from the endoplasmic reticulum (ER), and activates stromal interaction molecules (STIM1/2) to bind to the N- and C-termini of ORAI1 which form the subunit of the CRAC channel ( 13 ). The CRAC channel exhibits a notable preference for Ca 2+ and possesses remarkably low single-channel conductance ( 14 , 15 ). The influx of Ca 2+ into intracellular organelles is mediated by store-operated Ca 2+ entry (SOCE) ( 16 , 17 ) ( Figure 1 ).…”