Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1

Bourhanbour, Asmaa Drissi; Ouadghiri, S.; Benseffaj, N.; Essakalli, M.

doi:10.11604/pamj.2016.24.103.8555

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Our results display a relatively high prevalence of CD-specific auto-antibodies in Moroccan T1D patients. Actually, a similar Moroccan study has shown a higher rate of tTGA positivity (13%), but regarding the very small sample of adult T1D patients studied (31 cases), these data seem to overestimate the real prevalence of associated auto-antibodies to CD [4]. In contrary and in a similar context, Azzi et al [5] reviewed the records of 720 T1D pediatric patients and concluded a biopsy-proven CD prevalence of 3.05%.…”

Section: Discussionmentioning

confidence: 99%

“…In a meta-analysis gathering 27 studies with a total of 26,605 T1D patients, Elfström found that the overall prevalence of biopsy-proven CD is almost 6% [3]. Till now, there are few relevant published data about the prevalence of CD in the Moroccan general population and also in common clinical conditions usually associated with CD such as diabetes or autoimmune thyroiditis (AIT) [4, 5].…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

Oujamaa

Sebbani

Elmoumou

et al. 2019

International Journal of Endocrinology

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Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

Oujamaa

Sebbani

Elmoumou

et al. 2019

International Journal of Endocrinology

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“…discuss the prevalence of the CD-T1DM association in different areas of the world, by comparison with the Moroccan population. It also highlights the importance of CD screening in susceptible patients, especially due to the long-term risk of lymphoma or adenocarcinoma ( 213 ).…”

Section: Atypical Forms Of Celiac Diseasementioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

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Prevalence of autoimmune diseases and clinical significance of autoantibody profile: Data from National Institute of Hygiene in Rabat, Morocco

et al. 2019

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Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1

Cited by 3 publications

References 18 publications

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

Celiac disease - a pluripathological model in pediatric practice

Prevalence of autoimmune diseases and clinical significance of autoantibody profile: Data from National Institute of Hygiene in Rabat, Morocco

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