Dependence of mechanical compressive strength on local variations in microarchitecture in cancellous bone of proximal human femur

Perilli, Egon; Baleani, Massimiliano; Öhman, Caroline; Fognani, Roberta; Baruffaldi, Fabio; Viceconti, Marco

doi:10.1016/j.jbiomech.2007.08.003

Cited by 113 publications

(116 citation statements)

References 43 publications

(67 reference statements)

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“…However, this logical result is not supported by our data. Because of the heterogeneous nature of cancellous bone, there are areas with a different microarchitecture (Perilli et al, 2008). The depiction of the longitudinal surface strain field evolution during compression reflected the presence of stiffer or more compliant areas of trabecular bone throughout the specimen surface.…”

Section: Discussionmentioning

confidence: 99%

Combining Digital Image Correlation and Acoustic Emission for Monitoring of the Strain Distribution until Yielding during Compression of Bovine Cancellous Bone

Tsirigotis

Deligianni

2017

Front. Mater.

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In this work, the surface heterogeneity in mechanical compressive strain of cancellous bone was investigated with digital image correlation (DIC). Moreover, the onset and progression of failure was studied by acoustic emission (AE). Cubic cancellous bone specimens, with side of 15 mm, were obtained from bovine femur and kept frozen at −20°C until testing. Specimen strain was analyzed by measuring the change of distance between the platens (crosshead) and via an optical method, by following the strain evolution with a camera. Simultaneously, AE monitoring was performed. The experiments showed that compressive Young's modulus determined by crosshead strain is underestimated at 23% in comparison to optically determined strain. However, surface strain fields defined by DIC displayed steep strain gradients, which can be attributed to cancellous bone porosity and inhomogeneity. The cumulative number of events for the total AE activity recorded from the sensors showed that the activity started at a mean load level of 36% of the maximum load and indicated the initiation of micro-cracking phenomena. Further experiments, determining 3D strain with μCT apart from surface strain, are necessary to clarify the issue of strain inhomogeneity in cancellous bone.

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Section: Discussionmentioning

confidence: 99%

Combining Digital Image Correlation and Acoustic Emission for Monitoring of the Strain Distribution until Yielding during Compression of Bovine Cancellous Bone

Tsirigotis

Deligianni

2017

Front. Mater.

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“…Each specimen was cemented directly onto the testing machine. The free length of each specimen was 20 mm (Ohman et al, 2007;Perilli et al, 2008;Tassani et al, 2010). The same acquisition procedure was performed both before (pre-failure dataset) and after the mechanical testing (post-failure dataset).…”

Section: Methodsmentioning

confidence: 99%

“…The combination of the two techniques soon showed the importance of trabecular framework heterogeneity in the evaluation of the mechanical behavior of bone. Local analyses were suggested by several authors with different methodologies in order to take into consideration the variability of the structure in analysis (Nazarian et al, 2006;Perilli et al, 2008;Tassani et al, 2010). The study of local morphology leads to the study of the trabecular fracture zone itself, aiming to investigate the specific morphology that could explain the development of the trabecular framework failure.…”

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confidence: 99%

Trabecular Fracture Zone Might Not Be the Higher Strain Region of the Trabecular Framework

et al. 2018

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Trabecular bone fracture is a traumatic and localized event studied worldwide in order to predict it. During the years, researchers focused over the mechanical characterization of the trabecular tissue to understand its mechanics. Several studies pointed out the very local nature of the trabecular failure, finally identifying the fracture zone with the aim to study it separately. The complexity of the three-dimensional trabecular framework and the local nature of the fracture event do not allow the direct evaluation of a single trabecula's behavior within its natural environment. For this reason, micro-Finite Element Modeling has been seen as the best way to investigate this biomechanical issue. Mechanical strain analysis is adopted in the literature for the identification of micro fracture using criteria based on principal strains. However, it was never verified if the fracture zone is actually the zone where principal strains are concentrated. Here, we show how the maximum strain of the tissue might not be directly correlated to the fracture. In the present work, a previously validated technique was used to identify the fracture zone of 10 trabecular specimen mechanically tested in compression and scanned in micro-CT before and after the mechanical test. Before-compression datasets were used to develop 10 micro-FE models were the same boundary conditions of the mechanical test were reproduced. Our results show how the known linear behavior of the trabecular framework might not be directly related to the development of the fracture suggesting other non-linear phenomenon, like buckling or microdamage, as actual cause of the traumatic event. This result might have several implications both in micro-modeling and in clinical applications for the study of fracture related pathology, like osteoporosis.

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“…For these reasons the comparability and reproducibility of the results achieved often demands a larger number of test specimens. Comparative testing of orthopedic implants in human cadavers is very limited not only because of biological but of ethical, and economical reasons, too [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Compressive Properties of Commercially Available PVC Foams Intended for Use as Mechanical Models for Human Cancellous Bone

Oroszlány¹,

Nagy

Kovács

2015

APH

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Dependence of mechanical compressive strength on local variations in microarchitecture in cancellous bone of proximal human femur

Cited by 113 publications

References 43 publications

Combining Digital Image Correlation and Acoustic Emission for Monitoring of the Strain Distribution until Yielding during Compression of Bovine Cancellous Bone

Combining Digital Image Correlation and Acoustic Emission for Monitoring of the Strain Distribution until Yielding during Compression of Bovine Cancellous Bone

Trabecular Fracture Zone Might Not Be the Higher Strain Region of the Trabecular Framework

Compressive Properties of Commercially Available PVC Foams Intended for Use as Mechanical Models for Human Cancellous Bone

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