Deoxycholic Acid Injections for Bra-Line Lipolysis

Jegasothy, Shevanti Manjula

doi:10.1097/dss.0000000000001311

Cited by 21 publications

(21 citation statements)

References 2 publications

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“…Two published reports in which ATX-101 was used to treat fat deposits on the lateral sides of the breast in the axillary tail of Spence (similar to the current study) or adjacent to the bra strap in the posterior upper torso highlight the ongoing interest in using ATX-101 for body contouring. 14 , 15 The current study builds on these reports in multiple ways. Only 1 patient received ATX-101 treatment of APAF in each of the published reports, whereas the current study included 12 patients consistently evaluated and treated.…”

Section: Discussionmentioning

confidence: 97%

“…In the first of these published reports, improvement was based on reduction in tissue thickness as measured with calipers, 14 while in the second, improvement was determined by visual assessment of patient photographs and patient feedback. 15 In the current study, the evaluation of the reduction in APAF was also based on interpretation of changes between before and after treatment photographs by the patient and 2 blinded plastic surgeons, and on visual assessment and palpation of the anterior periaxillary area by the clinician, as no validated instrument for measuring APAF currently exists. Hence, development of tools or scales (with photonumeric guides) is needed to help clinicians accurately assess fat deposits in regions such as the anterior periaxillary region and determine if treatment was successful.…”

Section: Discussionmentioning

confidence: 99%

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Injection of an Adipocytolytic Agent for Reduction of Excess Periaxillary Fat

Shridharani¹

2019

Aesthetic Surgery Journal

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Background The principal current treatment options for reduction of excess anterior periaxillary fat (APAF) are invasive procedures such as excision and liposuction. Objectives The aim of this study was to evaluate the efficacy and safety of ATX-101 (deoxycholic acid injection) as a treatment to reduce APAF. Methods In this retrospective study, 12 women with periaxillary fullness underwent ATX-101 treatment. Patients were examined to confirm that fullness was due to excess APAF and sufficient subcutaneous fat was present to warrant treatment. Before treatment, the lateral and medial borders of the treatment area were identified and marked. A 1-cm grid was placed to guide the placement of the ATX-101 injections. Reduction in APAF was based on visual assessment and palpation by the clinician, and assessment of before/after patient photographs by the patient and 2 blinded plastic surgeons; all had to agree that APAF reduction had occurred. Patient satisfaction was also assessed. Safety was evaluated in terms of adverse events (AEs). Results Patients underwent a mean of 1.8 ATX-101 treatments; 5 patients received 1 treatment, whereas 7 received multiple treatments. Ten patients achieved a reduction in APAF and were satisfied with treatment. One patient was satisfied after 1 treatment but did not return for posttreatment photographs. One patient did not show any noticeable reduction in APAF after 1 treatment; however, this patient was satisfied and additional treatments are planned. Common AEs included injection-site numbness, edema, and tenderness that lasted for a mean of 18.6, 6.0, and 4.5 days, respectively. Conclusions ATX-101 effectively reduced APAF and was generally well tolerated in this small cohort. Larger prospective studies are needed to confirm these findings. Level of Evidence: 4

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Injection of an Adipocytolytic Agent for Reduction of Excess Periaxillary Fat

Shridharani¹

2019

Aesthetic Surgery Journal

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“…Recently, Jegasothy 11 injected DCA for bra-line lipolysis in 2 patients with good result. Therefore, I used DCA injection as a treatment for the painful fat herniation that occurs in PPP.…”

Section: Discussionmentioning

confidence: 99%

Piezogenic pedal papules treated successfully with deoxycholic acid injection

Turkmani¹

2018

JAAD Case Reports

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“…There are reported utilization for effective treatment for reduction of localized fat along the bra line and for potential body contouring throughout the body. [52][53][54] Within the face, deoxycholic acid has been shown as an option for correction of jowling. 55,56 Following an average of 1.8 AE 0.8 treatments, 98% of patients experienced jowl improvements by visual appraisal from the patient, clinician, and two blinded plastic surgeons.…”

Section: Deoxycholic Acid (Atx-101)mentioning

confidence: 99%

Tissue Modification in Nonsurgical Facelift Options

2020

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Nonsurgical facelifts are a term for a heterogeneous group of procedures used by physicians to improve facial rejuvenation without the use of operative techniques. Patients demand these services due to the reduced recovery time and generally lower risk. However, nonsurgical techniques, to be effective, must induce conformational change in the cells and tissues of the face. Therefore, these techniques are significant procedures that have associated risks. Understanding the tissue modifications and mechanisms of action of these techniques is vital to their safe and effective use. The purpose of this article is to provide a background of tissue modification in nonsurgical facelift options.

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Deoxycholic Acid Injections for Bra-Line Lipolysis

Cited by 21 publications

References 2 publications

Injection of an Adipocytolytic Agent for Reduction of Excess Periaxillary Fat

Injection of an Adipocytolytic Agent for Reduction of Excess Periaxillary Fat

Piezogenic pedal papules treated successfully with deoxycholic acid injection

Tissue Modification in Nonsurgical Facelift Options

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