Denture‐related stomatitis: identification of aetiological and predisposing factors – a large cohort

Abstract

The aim of this study was to identify and characterize aetiological and predisposing factors in denture-related stomatitis (DRS), by means of a case-control, transversal study, in a large cohort of 140 persons wearing removable maxillary polymethylamethacrylate prostheses. Data were obtained by (1) a questionnaire that included the identification of the subject, demographic and social data, medical history and behaviour; (2) intra-oral examination; (3) evaluation of the prosthesis; (4) microbiological examination; (5) yeast identification and analyses using Epi-info and the chi-square test. Results showed significant associations between DRS and yeasts, gender, age and alcohol consumption. We also found a significant relationship between the presence of yeasts and hyposalivation and decreased salivary pH. We found a highly significant difference between groups with and without DRS concerning the presence or absence of yeasts, regardless of the sample origin. Most cases of DRS showed the presence of Candida albicans. The results confirm a highly significant difference between groups with and without DRS concerning the presence or absence of yeasts.

Effect of wearing complete dental prosthesis on candidal count

“…This may be explained due to the fact that women have more candidal load on the basis of iron deficiency anemia and hormonal changes. [12][13][14] The majority of the women in the present study were in an age group where menopause was likely to occur. Most of the studies found that higher denture induced stomatitis in male patients in comparision to female.…”

Ocorrência de Candida na cavidade bucal de usuários de prótese dentária

“…The association between two species in the same lesion was frequent, mainly C. albicans and C. tropicalis that were observed in 36% of the samples. Figueiral et al 18 also report C. albicans as the most frequently isolated species, with values between 30% and 80%. Other prevalent species were C. glabrata, C. dubliniensis, C. tropicalis and C. parapsilosis.…”

“…In a study carried out by Figueiral et al 18 with 140 dental prosthesis users the authors report that 07.10% did not have yeasts, 81.40% hosted C. albicans; 07.10% presented C. glabrata, and an association between C. albicans + C. glabrata and C. tropicalis; C. tropicalis + C. glabrata; and C. albicans + C. tropicalis were verified in 01.40% each. In the control sample 52.90% of the participants did not host the yeast, and 27.20% had C. albicans.…”

Detecção da expressão dos genes HWP1, ALS1 e ALS3 de C.albicans, por meio de RT-PCR em tempo real, após desinfecção química e por microonda, de resina acrílica para confecção de dentaduras

“…Embora estudos correntes indiquem que a EP esteja geralmente associada com a presença do fungo C. albicans na saliva, na mucosa bucal e/ou na superfície interna da prótese removível WALKER, 1987;BARBEAU et al, 2003;CAMPOS et al, 2008;CUMMING et al, 1990;DAR-ODEH;SHEHABI, 2003;EMAMI et al, 2007;FARAH;ASHMAN;CHALLACOMBE, 2000;FIGUEIRAL et al, 2007;IACOPINO;WATHEN, 1992;KULAK;ARIKAN;KAZAZOGLU, 1997;PIRES et al, 2002;RAMAGE et al, 2004;WEBB et al, 1998;WILSON, 1998;ZISSIS;YANNIKAKIS;HARRISON, 2006), outros fatores também podem predispor seu desenvolvimento como os relacionados ao uso da prótese, à microbiota e às condições sistêmicas do hospedeiro.…”

“…A ausência de higiene bucal e da prótese promove um ambiente favorável à proliferação de microrganismos, principalmente entre a mucosa de suporte e a própria superfície da prótese (FIGUEIRAL et al, 2007). Destaca-se que outros microrganismos como, por exemplo, C. parapsilosis, C. tropicalis, C. glabrata, C. krusei, C. pseudotropicalis, C. dubliniensis e C. guilliermondi também podem colaborar para a patogênese da doença, no entanto, o fungo C. albicans é o mais freqüentemente associado (ARENDORF; WALKER, 1987;BARBEAU et al, 2003;DAR-ODEH;SHEHABI, 2003;EMAMI et al, 2007;FARAH;ASHMAN;CHALLACOMBE, 2000;FIGUEIRAL et al, 2007;FREITAS et al, 2008;IACOPINO;WATHEN, 1992;PIRES et al, 2002;RAMAGE et al, 2004;WILSON, 1998;ZISSIS;YANNIKAKIS;HARRISON, 2006 WALKER, 1987;BARBEAU et al, 2003;DAR-ODEH;SHEHABI, 2003;EMAMI et al, 2007;FARAH;ASHMAN;CHALLACOMBE, 2000;FIGUEIRAL et al, 2007;FREITAS et al, 2008;IACOPINO;WATHEN, 1992;PIRES et al, 2002;RAMAGE et al, 2004;WILSON, 1998;ZISSIS;YANNIKAKIS;HARRISON, 2006). …”