Dental Health and Mortality in People With End-Stage Kidney Disease Treated With Hemodialysis: A Multinational Cohort Study

Palmer, Suetonia C.; Ruospo, Marinella; Wong, Germaine; Craig, Jonathan C.; Ford, Pauline; Johnson, David W.; Tonelli, Marcello; Natale, Patrizia; Saglimbene, Valeria; Pellegrini, Fabio; Celia, Eduardo; Gelfman, Rubén; Leal, Miguel; Török, Marietta; Stroumza, P.; Bednarek-Skublewska, Anna; Duława, Jan; Frantzen, L.; Ferrari, Juan Nin; Castillo, Domingo del; Hegbrant, Jörgen; Wollheim, Charlotta; Gargano, Letizia; Bots, Casper P.; Strippoli, Giovanni F.M.; Rana, Shadab N.; Serrano, M.T.; Claros, S.; Arias, Manuel; Petracci, L.; Arana, M.; Rosa, P. De; Gutiérrez, Alicia Hernández; Simon, M.; Vergara, Vanessa; Tosi, Maurizio; Cernadas, Manuela; Vilamajó, Inmaculada Ros; Gravac, D.; Paulon, M.; Penayo, L.; Carrizo, G.; Ghiani, M.; Perez, Galit; Cruz, O. Da; Galarce, D.; Gravielle, M.; Vescovo, Ester Del; Paparone, R.; Mira, Cristina; Mojico, Edgardo Roberto; Hermida, O.; Florio, D.; Yucoswky, M.; Labonia, W.; Rubio, Dolores Mesa; Napoli, Gianluigi; Fernández, A.; Altman, H; Rodriguez, Juan L.; Serrano, Salvio; Valle, G.; Lobos, M.; Acosta, V.; Corpacci, G.; Jofre, M.; Gianoni, L.; Chiesura, G.; Capdevila, Marta; Montenegro, Jesús Lechuga; Bequi, J.; Dayer, Julie-Anne; Gómez, Adán Cervantes; Calderón, Claudia; Abrego, E.; Cechin, Cláudia; García, José Miguel Zaragozá; Corral, Javier; Natiello, Marcela; Coronel, Agustín; Muñiz, M.; Muniz, Virginia Maria; Bonelli, Aurelio; Sánchez, Fernando Pardo; Maestre, S.; Olivera, Silvia Leonor; Camargo, Maria Fernanda Carvalho de; Avalos, V.; Geandet, E.; Canteli, M.; Escobar, Ana Maria de Ulhôa; Sena, Elisama Araújo de; Tirado, Silvia; Peñalba, Adriana; Neme, Gustavo; Cisneros, Morales; Oliszewski, R.; Nascar, V.; Daud, Mat; Mansilla, S.; Alvarez, Angie; Gamín, L.; Arijón, M.; Coombes, Megan; Zapata, Manuel Franco; Boriceanu, C.; Albert, K.; Csaszar, I.; Kiss, Éva; Kosa, D.; Orosz, A; Redl, J.; Kovács, Lajos; Varga, Eva‐Maria; Szabó, Melinda Zsuzsanna; Magyar, Karl P.; Kriza, G.; Zajko, E.; Bereczki, A.; Csikós, J.; Kuti, A.; Mike, A.; Steiner, Kevin L.; Nemeth, Elizabeta; Tolnai, K.; Tóth, Attila; Vinczene, J.; Szummer, Sz.; Tanyi, E.; Tóth, Réka; Szilvia, M.; Dambrosio, N.; Paparella, Gaetano; Sambati, M; Donatelli, Christopher; Pedone, F.; Cagnazzo, V.A.; Antinoro, R.; Torsello, Ferruccio; Saturno, C.; Giannoccaro, G; Maldera, S.; Boccia, Edda; Mantuano, Michele; Mammarella, R. Di Toro; Meconizzi, M.; Steri, P.; Riccardi, Carla; Flammini, Alessia; Moscardelli, L.; Murgo, Marco; Filippo, N. San; Pagano, Sabrina; Marino, G.; Montalto, Giuseppe; Cantarella, S.; Salamone, B.; Randazzo, Giorgio; Rallo, D.; Maniscalco, A.; Fici, M.; Lupo, A; Pellegrino, Pier Luigi; Fichera, R.; D’Angelo, Angela; Falsitta, N.; Bocheńska-Nowacka, E; Jaroszyński, Andrzej; Drabik, Józef; Birecka, Magdalena; Daniewska, Dorota; Drobisz, M; Doskocz, Krzysztof; Wyrwicz, Grazyna; Inchaustegui, Luís; Outerelo, Cristina; Mendes, Dina; Mendes, Adell; Lopes, José António; Barbas, J A Moreno; Madeira, Carolina; Fortes, Alice; Vizinho, Ricardo; Cortesão, A.; Almeida, Eliete Rodrigues de; Bernat, A.; Torre, B de la; López, Adriana Posada; Martín, James; Cuesta, G.; Rodriguez, R. M.; Ros, F.; García, Miguel Ángel García; Orero, E.; Ros, Emilio; Caetano, André; MacGregor, Katie; Santos, Marcos Antônio Pereira dos; Pinheiro, S. Silva; Martins, Leonardo Rodrigues; Leitão, Dina; Izidoro, Catarina; Bava, G; Bora, Akshay K; Gorena, H.; Calderon, Tirza Areli; Dupuy, Richard; Alonso, Noemí Acedo; Siciliano, Vincenzo Iorio; Frantzen-Trendel, S.; Nagy, K.; Bajusz, Ö.; Pinke, Ildikó; Decsi, Gábor; Gyergyoi, L.; Jobba, Zs.; Zalai, Zs.; Zsedenyi, Á.; Kiss, Gabriella Ilona; Pinter, Matthias; Keresztúri, Márk; Petruzzi, Massimo; Benedittis, M. De; Szkutnik, Jacek; Sieczkarek, J.; Capelo, Albertina Varandas; Gallart, Montserrat; Mendieta, C.

doi:10.1053/j.ajkd.2015.04.051

Cited by 62 publications

(69 citation statements)

References 32 publications

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“…If it is difficult to verify the effectiveness of interventional studies, prospective observational studies can be preferred as a suboptimal solution to strengthen the causal relationship. Accordingly, prospective observational studies, such as ORAL‐D study , that examine the relationship between PD‐related peritonitis and oral disease in addition to oral hygiene habits should be carried out in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Patients who carried out oral hygiene at least twice a day had a marginally significantly (P = 0.10) lower risk of PD-related peritonitis than those who did not (HR 0.56 [95% CI, 0.28-1.12]). Conversely, there were no (8) significant differences in the risk of PD-related peritonitis between patients with or without the use of dental floss (HR 0.65 [95% CI, 0.24-1.50], P = 0.33) or between patients who last attended the dentist within 1 year or more than 1 year ago (HR 1.22 [95% CI, 0.61-2.45], P = 0.58). Consistent results were obtained even in the analysis using a Fine-Gray proportional hazards model (data not shown).…”

Section: Association Between Pd-related Peritonitis and Oral Hygiene mentioning

confidence: 97%

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Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis‐Related Peritonitis

et al. 2018

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Some peritoneal dialysis (PD)‐related peritonitis cases are thought to be caused by the pathogens in the oral cavity; however, the relationship between peritonitis and oral hygiene habits is unclear. In this study, we retrospectively examined the relationship between oral hygiene habits and peritonitis in patients who agreed to a questionnaire survey. Of the 75 patients, 37 patients developed PD‐related peritonitis during the observation period. Peritonitis‐free survival was significantly higher in patients who spent more time on oral hygiene daily and in patients who replaced their toothbrush more frequently (P < 0.05). According to multivariable analysis, increased daily oral hygiene duration and more frequent toothbrush replacement were associated with a significantly (P < 0.01) lower risk for peritonitis (hazard ratio [HR] 0.37 [95% CI, 0.18–0.77] and HR 0.35 [95% CI, 0.17–0.70], respectively). In conclusion, PD patients with superior oral hygiene habits showed a lower risk for PD‐related peritonitis.

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Section: Discussionmentioning

confidence: 99%

Section: Association Between Pd-related Peritonitis and Oral Hygiene mentioning

confidence: 97%

Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis‐Related Peritonitis

et al. 2018

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“…Furthermore, large epidemiological studies indicate that poor oral health could have an adverse effect on general health in people with reduced kidney function. For instance, periodontitis and tooth loss were demonstrated to be associated with higher mortality (Palmer et al, 2015; Ricardo et al, 2015). These problems related to periodontitis can have negative impacts on perceived general health and be reflected in deterioration in HRQoL measured by means of the SF‐36.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and health‐related quality of life in hemodialysis patients

Iwasaki

Borgnakke

Awano

et al. 2016

Clinical & Exp Dental Res

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Periodontitis is common among dialysis patients. The current cross‐sectional study aimed to explore associations between periodontitis and health‐related quality of life (HRQoL) among hemodialysis patients. Data from 188 dentate patients undergoing hemodialysis between May and July 2008 at a medical center in Kitakyushu city, Japan, were analyzed while applying modified Centers for Disease Control and Prevention/American Academy of Periodontology periodontitis case definitions to categorize the participants into the following three groups: severe, moderate, and no/mild periodontitis, respectively. HRQoL was assessed by the Medical Outcomes Study 36‐Item Short Form Health Survey (SF‐36) where a higher score indicates better health status. Associations between periodontitis groups and the eight health domains of SF‐36 were evaluated using general linear models that were adjusted for age, sex, underlying cause of dialysis, duration of dialysis, comorbidities, serum biomarkers, body mass index, smoking status, and alcohol use. Among the 188 participants, 18 (9.6%) had severe periodontitis, 100 (53.2%) had moderate periodontitis, and the remaining 70 (37.2%) had no/mild periodontitis. Compared with the participants with no/mild periodontitis, those with severe periodontitis had worse scores in the following five of eight SF‐36 health scales: physical functioning, role physical, vitality, social functioning, and mental health (P < 0.05). The findings suggest an independent relationship between severe periodontitis and decreased HRQoL among dialysis patients.

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“…Individuals undergoing dialysis typically have very poor oral health, [136][137][138][139][140][141][142] and for those with long-term hemodialysis, periodontitis is associated with an increased mortality. 137,140,143 One study reported a higher periodontitis risk for older Japanese women with lower cystatin C-based estimated glomerular filtration rate (eGFR).…”

Section: Chronic Kidney Diseasementioning

confidence: 99%

Does Treatment of Periodontal Disease Influence Systemic Disease?

Borgnakke

2015

Dental Clinics of North America

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Dental Health and Mortality in People With End-Stage Kidney Disease Treated With Hemodialysis: A Multinational Cohort Study

Abstract: In adults treated with hemodialysis, poorer dental health was associated with early death, whereas preventive dental health practices were associated with longer survival.

Cited by 62 publications

References 32 publications

Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis‐Related Peritonitis

Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis‐Related Peritonitis

Periodontitis and health‐related quality of life in hemodialysis patients

Does Treatment of Periodontal Disease Influence Systemic Disease?

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