Dengue virus and SARS-CoV-2 Co-infection dynamics: An emerging threat among African countries

Oladipo, Habeebullah Jayeola; Rabiu, Ismail; Tajudeen, Yusuf Amuda

doi:10.1016/j.amsu.2022.104398

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Global warming has been factored into models that predict changes in the distributions of Aedes aegypti and Aedes albopictus, as well as associated changes in vector-borne diseases [32,33]. However, Walter and colleagues stated that it is difficult to predict the future consequences of global climate change on arbovirus evolution because, for example, the factors that influence the evolution and diversity of DENV and YFV are diverse, complex, and lack the impact of long-term climate change [33,34]. This requires greater data gathering and mapping that predicts potential consequences of climate change on a wider range of arthropod species together with their arbovirus evolution.…”

Section: The Statistical Mechanistic Integrated Surveillance Thermal ...mentioning

confidence: 99%

Adopting a Statistical, Mechanistic, Integrated Surveillance, Thermal Biology, and Holistic (SMITH) Approach for Arbovirus Control in a Changing Climate: A Review of Evidence

et al. 2023

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Arbovirus control depends on accurate projections of likely changes in the arthropod vector species, essential to inform local and global public health authorities. According to the WHO Assembly and the Global Vector Control Response (GVCR), by 2030, the burden of vector-borne diseases, particularly arbovirus infections, is expected to be greatly decreased. However, anthropogenic drivers, including climate change, insecticide resistance, and a lack of operational local databases for risk management of emerging and re-emerging arboviruses, hinders effective implementation plans. This article presents a statistical, mechanistic, integrated surveillance, thermal biology, and holistic framework (termed SMITH) to discuss how temperature variations affect the biological transmission, replication, extrinsic incubation period, nutritional behavior, distribution, and survival (TRENDS) of arboviruses. Future transdisciplinary research that involves knowledge translation between local and global communities is required for early detection and risk management of the growing threat posed by arboviruses for human, animal, and planetary health.

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Section: The Statistical Mechanistic Integrated Surveillance Thermal ...mentioning

confidence: 99%

Adopting a Statistical, Mechanistic, Integrated Surveillance, Thermal Biology, and Holistic (SMITH) Approach for Arbovirus Control in a Changing Climate: A Review of Evidence

et al. 2023

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“…Dengue fever is an endemic illness in many tropical nations, particularly in their metropolitan regions (Valencia et al [39]). More than half of the globe is affected by this virus, which places a heavy cost on public health systems everywhere (Shragai et al [35], and Oladipo et al [24]).…”

Section: Introductionmentioning

confidence: 99%

Sensitivity Analysis of Vector-host Dynamic Dengue Epidemic Model

Hasan,

Hobiny,

Alshehri

2023

Comm. Math. Appl.

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A global health hazard, dengue fever causes or contributes to the deaths of 10,000 people and 100 million cases of symptomatic cases every year in more than half of the globe. The goal of this work is to construct a compartmental vector-borne dengue model that takes into account the typical incidence connection between infected humans and susceptible vectors in order to examine the impact of model parameters that are within our control on the basic reproduction number. In order to determine the basic reproduction number R 0 , the next-generation matrix is used. The theoretical study reveals that disease-free equilibrium occurs as a locally asymptotically stable if R 0 < 1. To measure the disease-free and endemic equilibrium points' global stability, LaSalle's concept is applied. The normalized forward sensitivity index methods show that the epidemic spread can reduce by increasing the rate of symptomatically infected humans to isolated infected humans and the rate of recovery of symptomatically infected humans.

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“…Among these territories, the DENV-SARS-CoV-2 co-infection has been a serious situation, which has been Molecules 2023, 28, 160 2 of 15 one of the focus issues on COVID-19 epidemiology. Thus, developing broad-spectrum antiviral agents blocking both SARS-CoV-2 and DENV is a promising strategy to alleviate the public health burden in certain areas around the world [7,8]. Although supportive therapy of dengue fever remarkably reduced the mortality rate, no specific therapy agents towards DENV were approved.…”

Section: Introductionmentioning

confidence: 99%

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Gao

Song

et al. 2022

Molecules

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The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation. Here, two piperazine-based polyphenol derivatives DF-47 and DF-51 were identified as potential inhibitors directly blocking the active site of SARS-CoV-2 and DENV RdRp. Data through RdRp inhibition screening of an in-house library and in vitro antiviral study selected DF-47 and DF-51 as effective inhibitors of SARS-CoV-2/DENV polymerase. Moreover, in silico simulation revealed stable binding modes between the DF-47/DF-51 and SARS-CoV-2/DENV RdRp, respectively, including chelating with Mg2+ near polymerase active site. This work discovered the inhibitory effect of two polyphenols on distinct viral RdRp, which are expected to be developed into broad-spectrum, non-nucleoside RdRp inhibitors with new scaffold.

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Dengue virus and SARS-CoV-2 Co-infection dynamics: An emerging threat among African countries

Cited by 6 publications

References 34 publications

Adopting a Statistical, Mechanistic, Integrated Surveillance, Thermal Biology, and Holistic (SMITH) Approach for Arbovirus Control in a Changing Climate: A Review of Evidence

Adopting a Statistical, Mechanistic, Integrated Surveillance, Thermal Biology, and Holistic (SMITH) Approach for Arbovirus Control in a Changing Climate: A Review of Evidence

Sensitivity Analysis of Vector-host Dynamic Dengue Epidemic Model

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

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