2008
DOI: 10.1086/528805
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Abstract: Viremia was detected after defervescence in adult patients classified as having DHF or intermediate DF/DHF. Secondary infection was not a predictor of severe clinical manifestation in adults with infected with the DV3 serotype.

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Cited by 142 publications
(125 citation statements)
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“…This finding is in agreement with the fact that dengue is an acute infectious disease, which affects persons independent of their previous health status. 2,41 Most of the patients in our study were classified as having DF. In a study in Malaysia in which patients were assessed by using the same instrument, patients generally had more severe dengue (DHF or DF with plasma leakage).…”
Section: Discussionmentioning
confidence: 94%
“…This finding is in agreement with the fact that dengue is an acute infectious disease, which affects persons independent of their previous health status. 2,41 Most of the patients in our study were classified as having DF. In a study in Malaysia in which patients were assessed by using the same instrument, patients generally had more severe dengue (DHF or DF with plasma leakage).…”
Section: Discussionmentioning
confidence: 94%
“…The data imply that the differences between serotypes and viral load can contribute to determine disease progression. 4,9,34 In our study, we examined the levels of immunoregulatory cytokines IL-6, IL-8, and IL-10 to gain greater insights into possible roles for these cytokines in the earliest phases of disease development, between days 1 and 4 of the onset of symptoms.…”
Section: Discussionmentioning
confidence: 99%
“…More recently, many cases of dengue hemorrhagic fever have been diagnosed in patients without primary dengue infection, that is, individuals without antibodies from previous infections 37,40 . Since such cases do not fit with the premises of the Halstead hypothesis of sequential infections 4 , research is needed to elucidate which other factors are involved, such as viral strain virulence, as reported since the 1970s 41 , host genetics 32 , presence of co-morbidtiy 37,39 , and others that can contribute to dengue severity.…”
Section: Revisiting Dengue Epidemiology In Brazilmentioning
confidence: 99%