Dendritic Spine and Synaptic Plasticity in Alzheimer’s Disease: A Focus on MicroRNA

Reza-Zaldívar, Edwin E.; Hernández-Sapiéns, Mercedes A.; Minjarez, Benito; Gómez‐Pinedo, Ulises; Sánchez-González, Víctor J.; Márquez-Aguirre, Ana Laura; Canales-Aguirre, Alejandro A.

doi:10.3389/fcell.2020.00255

Cited by 52 publications

(43 citation statements)

References 75 publications

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“…The dendritic spine number and shape affect synaptic plasticity, memory consolidation, and cognitive deficit in brain diseases 29 . To elucidate whether change in neurite complexity by metabolic imbalance and exendin-4 reflects alteration of dendritic spine morphology that indirectly represent synaptic plasticity and LTP in the mice brain, we examined the effect of exendin-4 on dendritic spine maturation in metabolic-imbalanced primary hippocampal and cortical neurons.…”

Section: Resultsmentioning

confidence: 99%

Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

Wang

Yoon

Song

et al. 2021

Sci Rep

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Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. Although GLP-1 and GLP-1 receptor agonists appear to have neuroprotective function, the specific mechanism of their action in brain remains unclear. We investigated whether exendin-4, as a GLP-1RA, improves cognitive function and brain insulin resistance in metabolic-imbalanced mice fed a high-fat diet. Considering the result of electrophysiological experiments, exendin-4 inhibits the reduction of long term potentiation (LTP) in high fat diet mouse brain. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition. Our results showed the improvement of IRS-1 phosphorylation, neuronal complexity, and the mature of dendritic spine shape by exendin-4 treatment in metabolic imbalanced in vitro condition. Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure. We suggest that GLP-1 is important to treat neuropathology caused by metabolic syndrome.

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Section: Resultsmentioning

confidence: 99%

Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

Wang

Yoon

Song

et al. 2021

Sci Rep

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“…Targeting synaptic deficits in AD patients and aging individuals by improving synaptic plasticity though alteration of structural deficits in dendritic spines through microRNA mediated regulatory pathways could be an effective and novel therapeutic strategy for AD as well as other neurodegenerative disorders [126].…”

Section: Author Detailsmentioning

confidence: 99%

Neurological and Neuropsychiatric Disorders in Relation to Olfactory Dysfunction

Bhatia‐Dey¹,

Heinbockel²

2020

Sino-Nasal and Olfactory System Disorders [Working Title]

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Olfaction is an underestimated sensory modality in terms of its predictive value as an indicator of disorders. It is a well-known phenomenon that a significant percentage of people afflicted with certain prevalent disorders causing degenerative neuropathology, progressive loss of memory and communication function, normal age-based decline of physiological functions, intellectual challenges, depressive and anxiety disorders as well as post-traumatic stress disorders, present with a range of olfactory deficits. Here, we review our understanding of these deficits and their relation to various clinical manifestations such as neurological and neuropsychiatric diseases and disorders. At the outset, we will briefly describe the olfactory pathway from olfactory sensory neurons in the nasal epithelium to the olfactory bulb and on to olfactory cortical and subcortical structures involved in olfaction such as the amygdala.

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“…It has been reported that the dendritic spine's number and shape affect synaptic plasticity, memory consolidation, and cognitive deficit in brain diseases 23 . To further elucidate whether the changes of neurite formation and complexity by metabolic imbalances and exendin-4 reflect the alteration of dendritic spine morphology that indirectly represent synaptic plasticity and LTP in the mice brain, we tried to examine the dendritic spine maturation in neurons under the metabolic imbalance condition.…”

Section: Exendin-4 Improved Neuronal Dendrite Outgrowth and Dendriticmentioning

confidence: 99%

Exendin-4 Improves Long-Term Potentiation and Neuronal Dendritic Growth in High-Fat Diet Mice and Neurons Under Metabolic Imbalance Conditions

Song¹,

Wang²,

Yoon³

et al. 2020

Preprint

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Metabolic syndrome, which increases the risk of obesity and type 2 diabetes, has emerged as a significant issue worldwide. Metabolic syndrome can occur due to diverse factors such as genetic background, lifestyle changes, food intake, and aging. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies, such as synaptic dysfunction and memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells, and specific brain nuclei play multiple roles, including glucose metabolism, regulation of insulin sensitivity, inflammation control, synaptic plasticity improvement, and neuronal protection. Even though GLP-1 and GLP-1 receptor agonists (GLP-1RA) appear to have neuroprotective functions, the specific mechanisms of GLP-1 and GLP-1RA in brain function have remained unclear. Here, we investigated whether exendin-4 improves cognitive function and brain insulin resistance in metabolic imbalanced high-fat diet mice brain as a GLP-1RA, using electrophysiological experiments. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons under an in vitro metabolic imbalance condition, including neuronal structure improvement. This study provides significant findings on the effects of exendin-4 in synaptic plasticity, long-term potentiation (LTP), neuroinflammation, and neural structure. We suggest that GLP-1 may be vital to treating neuropathology caused by metabolic imbalance.

show abstract

Dendritic Spine and Synaptic Plasticity in Alzheimer’s Disease: A Focus on MicroRNA

Cited by 52 publications

References 75 publications

Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

Neurological and Neuropsychiatric Disorders in Relation to Olfactory Dysfunction

Exendin-4 Improves Long-Term Potentiation and Neuronal Dendritic Growth in High-Fat Diet Mice and Neurons Under Metabolic Imbalance Conditions

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