Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Lee, Hana; Tian, Linjie; Bouladoux, Nicolas; Davis, Jacquice; Quiñones, Mariam; Belkaid, Yasmine; Coligan, John E.; Krzewski, Konrad

doi:10.1172/jci89531

Cited by 21 publications

(28 citation statements)

References 54 publications

(74 reference statements)

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“…We have recently shown that baseline tissue expression of CD300f (at least in the colon and adipose tissue) is nearly exclusively confined to eosinophils as other tissue resident cells such as macrophages, DCs and mast cells barely express CD300f . In contrast to our findings, other groups have reported that CD300f in the colon is expressed by mast cells, macrophages and DCs . These data suggest that different housing protocols and/or different exposure to food antigens and perhaps endotoxins could regulate the expression of CD300f.…”

Section: Expression Of Cd300 Receptors By Eosinophilscontrasting

confidence: 97%

“…27,28 In contrast to our findings, other groups have reported that CD300f in the colon is expressed by mast cells, macrophages and DCs. 29,30 These data suggest that different housing protocols and/or different exposure to food antigens and perhaps endotoxins could regulate the expression of CD300f. We have shown that induction of colitis by dextran sodium sulfate (DSS) resulted in decreased expression of CD300f by colonic eosinophils and increased expression by monocytes/macrophages.…”

Section: Expression Of Cd300 Receptors By Eosinophilsmentioning

confidence: 93%

“…The regulatory role of CD300f in innate immune response by eosinophils was further validated in vitro where heat‐inactivated Escherichia coli activation of BM derived Cd300f −/− eosinophils resulted in decreased cytokine secretion and phosphorylation of pro‐inflammatory cell signaling molecules . In contrast to these findings, two other studies assessed the roles of CD300f in colitis and reported exacerbated colitis in Cd300f −/− mice compared with wild‐type mice . Interestingly, these latter studies reported distinct inhibitory activities for CD300f.…”

Section: Cd300f Regulates Innate Immune Responses Of Eosinophils In Cmentioning

confidence: 98%

“…Matsukawa et al . demonstrate that interactions between CD300f and ceramide inhibited ATP‐stimulated activation of colonic mast cells, whereas Lee et al., demonstrate a failure of Cd300f −/− mice to resolve colonic inflammation, due to defects in DC function associated with abnormal apoptotic cell build‐up in the gut. Thus, CD300f‐deficient DCs display hyperactive phagocytosis of apoptotic cells, which stimulates excessive TNF‐α secretion and subsequently prolonged colonic inflammation.…”

Section: Cd300f Regulates Innate Immune Responses Of Eosinophils In Cmentioning

confidence: 99%

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CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions

Rozenberg

Reichman

Moshkovits

et al. 2017

Journal of Leukocyte Biology

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The CD300 family of receptors is an evolutionary conserved receptor family that belongs to the Ig superfamily and is expressed predominantly by the myeloid lineage. Over the past couple of years, accumulating data have shown that eosinophils express various Ig superfamily receptors that regulate key checkpoints in their biology including their maturation, transition from the bone marrow to the peripheral blood, migration, adhesion, survival, and effector functions in response to numerous activating signals such as IL-4, IL-33, and bacteria. In this review, we will present the emerging roles of CD300 family receptors and specifically CD300a and CD300f in the regulation of these eosinophil activities. The structure and expression pattern of these molecules will be discussed and their involvement in suppressing or co-activating eosinophil functions in health and disease will be illustrated.

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Section: Expression Of Cd300 Receptors By Eosinophilscontrasting

confidence: 97%

Section: Expression Of Cd300 Receptors By Eosinophilsmentioning

confidence: 93%

Section: Cd300f Regulates Innate Immune Responses Of Eosinophils In Cmentioning

confidence: 98%

Section: Cd300f Regulates Innate Immune Responses Of Eosinophils In Cmentioning

confidence: 99%

See 2 more Smart Citations

CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions

Rozenberg

Reichman

Moshkovits

et al. 2017

Journal of Leukocyte Biology

View full text Add to dashboard Cite

show abstract

“…Over the past few years, several publications have highlighted the important role the CD300 family of receptors has in complex biological processes such as phagocytosis, proliferation, and cytokine production [7, 12,13,17,24,25,30,31,39,40], and in a variety of diseases, including autoimmune disorders, allergic and inflammatory diseases, hematological malignancies, sepsis, etc. [7,12,17,19,21,33,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. Here, we review several aspects involving the CD300 molecules and viral infections, including how viruses use these receptors to interact with and enter cells or to escape from the attack of the immune system.…”

Section: Introductionmentioning

confidence: 99%

CD300 receptor family in viral infections

et al. 2018

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The CD300 molecules constitute an evolutionarily significant family of receptors that are expressed on myeloid and lymphoid cells, but also on other cell types, such as tuft cells. Many of the CD300 receptors have been shown to recognize lipids, e.g. phosphatidylserine and phosphatidylethanolamine. Over the past couple of years, accumulating evidence has shown that this family of receptors is involved in the pathogenesis of many diseases. Specifically, CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells. The participation of CD300 molecules in viral infection includes both lipid dependent and independent mechanisms, as for example in infections with dengue virus (DENV) and murine norovirus (MNV), respectively. CD300 receptors are also involved in viral escape mechanisms, for instance inhibiting NK cell‐mediated cytotoxicity against infected cells. Moreover, it is becoming increasingly recognized that the expression of CD300 receptors is altered during viral diseases. Here, we review the involvement of human and murine CD300 molecules in viral binding and entry and in cellular responses to viruses, which highlights the potential of CD300 molecules in the search of new biomarkers for various stages of infection and therapeutic targets for the treatment of viral infections.

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Pan‐cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia

Jin

Zhang

et al. 2022

Cancer Medicine

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Background CD300s are a group of proteins playing vital roles in immune responses. However, much is yet to be elucidated regarding the expression patterns and clinical significances of CD300s in cancers. Methods In this study, we comprehensively investigated CD300s in a pan‐cancer manner using multi‐omic data from The Cancer Genome Atlas. We also studied the relationship between CD300s and the immune landscape of AML. Results We found that CD300A ‐ CD300LF were generally overexpressed in tumors (especially AML), whereas CD300LG was more often downregulated. In AML, transactivation of CD300A was not mediated by genetic alterations but by histone modification. Survival analyses revealed that high CD300A ‐ CD300LF expression predicted poor outcome in AML patients; the prognostic value of CD300A was validated in seven independent datasets and a meta dataset including 1115 AML patients. Furthermore, we demonstrated that CD300A expression could add prognostic value in refining existing risk models in AML. Importantly, CD300A ‐ CD300LF expression was closely associated with T‐cell dysfunction score and could predict response to AML immunotherapy. Also, CD300A was found to be positively associated with HLA genes and critical immune checkpoints in AML, such as VISTA , CD86 , CD200R1 , Tim‐3 , and the LILRB family genes. Conclusions Our study demonstrated CD300s as potential prognostic biomarker and an ideal immunotherapy target in AML, which warrants future functional and clinical studies.

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Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

Cited by 21 publications

References 54 publications

CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions

CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions

CD300 receptor family in viral infections

Pan‐cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia

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