Dendrites of rod bipolar cells sprout in normal aging retina

Liets, Lauren C.; Eliasieh, Kasra; List, Deborah A. van der; Chalupa, Leo M.

doi:10.1073/pnas.0605211103

Cited by 102 publications

(105 citation statements)

References 33 publications

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“…Amacrinal and horizontal cells feed into this synaptic tree which has an extraordinary capacity for plasticity 31. Plasticity of the INL is also exploited for retinal implants 32 33.…”

Section: Discussionmentioning

confidence: 99%

A dam for retrograde axonal degeneration in multiple sclerosis?

Balk

Twisk

Steenwijk

et al. 2014

Journal of Neurology, Neurosurgery & Psychiatry

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“…Amacrinal and horizontal cells feed into this synaptic tree which has an extraordinary capacity for plasticity 31. Plasticity of the INL is also exploited for retinal implants 32 33.…”

Section: Discussionmentioning

confidence: 99%

A dam for retrograde axonal degeneration in multiple sclerosis?

Balk

Twisk

Steenwijk

et al. 2014

Journal of Neurology, Neurosurgery & Psychiatry

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“…However, reorganization of retinal circuitry is also found in normal aging retina (Liets et al, 2006;Eliasieh et al, 2007). Horizontal cell and/or rod bipolar cell dendrites sprout into nuclear layers of the retina, and ectopic sites containing mislocalized synaptic material are apparent.…”

Section: Remodeling Of Inner Retinal Neuronsmentioning

confidence: 96%

Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods

Haverkamp

Specht

Majumdar

et al. 2007

J of Comparative Neurology

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Immunocytochemical discrimination of distinct bipolar cell types in the mouse retina is a prerequisite for analyzing retinal circuitry in wild-type and transgenic mice. Here we demonstrate that among the more than 10 anatomically defined mouse bipolar cell types, type 4 bipolar cells are specifically recognized by anti-calsenilin antibodies. Axon terminals in the inner plexiform layer are not readily identifiable because calsenilin is also expressed in a subset of amacrine and ganglion cells. In contrast, in the outer plexiform layer calsenilin immunoreactivity allows the analysis of photoreceptor to type 4 bipolar cell contacts. A dense plexus of calsenilin-positive dendrites makes several basal contacts at cone pedicles. An individual calsenilin-positive bipolar cell contacts five to seven cones. In addition, some calsenilin-positive dendrites contact rod photoreceptors. On average we counted 10 rod spherule contacts per type 4 bipolar cell, and approximately 10% of rods contacted type 4 bipolar cells. We suggest that type 4 bipolar cells, together with the recently described type 3a and b cells, provide an alternative and direct route from rods to OFF cone bipolar cells. In the Bassoon DeltaEx4/5 mouse, a mouse mutant that shows extensive remodeling of the rod system including sprouting of horizontal and rod bipolar cells into the outer nuclear layer due to impaired synaptic transmission, we found that in addition mixed-input (type 3 and 4) OFF bipolar cells sprout to ectopic sites. In contrast, true cone-selective type 1 and 2 OFF cone bipolar cells did not show sprouting in the Bassoon mouse mutant.

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“…In ageing humans (up to 90 years), there is a 30% decrease in the number of rods in the central retina, but interestingly, rod inner segments increase in size by 13.5%, compensating for the loss in rod numbers (Curcio et al, 1993). In the ageing mouse retina, rod bipolar cell dendrites and horizontal cell arborizations sprout new neuronal processes that make aberrant, ectopic extensions into the outer nuclear layer; normally cell processes from these neurons would be limited to the outer plexiform layer where they form synapses with terminals from photoreceptor neurons (Liets et al, 2006; Terzibasi et al, 2009; Samuel et al, 2011). Light and electron microscope immunocytochemistry indicate that these processes can form ribbon synapses with rod cells and have postsynaptic mGluR6 (metabotropic glutamate receptor).…”

Section: Retinamentioning

confidence: 99%

Communication breakdown: The impact of ageing on synapse structure

Petralia

Mattson

Yao

2014

Ageing Research Reviews

105

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Impaired synaptic plasticity is implicated in the functional decline of the nervous system associated with ageing. Understanding the structure of ageing synapses is essential to understanding the functions of these synapses and their role in the ageing nervous system. In this review, we summarize studies on ageing synapses in vertebrates and invertebrates, focusing on changes in morphology and ultrastructure. We cover different parts of the nervous system, including the brain, the retina, the cochlea, and the neuromuscular junction. The morphological characteristics of aged synapses could shed light on the underlying molecular changes and their functional consequences.

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Dendrites of rod bipolar cells sprout in normal aging retina

Cited by 102 publications

References 33 publications

A dam for retrograde axonal degeneration in multiple sclerosis?

A dam for retrograde axonal degeneration in multiple sclerosis?

Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods

Communication breakdown: The impact of ageing on synapse structure

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