Dendrimer-based micelles as cyto-compatible nanocarriers

Parshad, Badri; Yadav, Preeti; Kerkhoff, Yannic; Mittal, Ayushi; Achazi, Katharina; Haag, Rainer; Sharma, Sunil K.

doi:10.1039/c9nj02612f

Cited by 16 publications

(20 citation statements)

References 35 publications

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“…As a part of our ongoing research program to synthesize a wide variety of amphiphilic nanocarrier systems capable of forming different morphological aggregates because of varied hydrophilic and hydrophobic segments, herein, we have used triglycerol, an oligomer of glycerol, as a backbone.…”

Section: Introductionmentioning

confidence: 95%

Fabrication of oligo‐glycerol based hydrolase responsive amphiphilic nanocarriers

Mittal

Singh

Kumar

et al. 2020

Polymers for Advanced Techs

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Herein, we report on the synthesis of a new class of novel non-ionic amphiphiles using triglycerol as a core, which is further functionalized with hydrophilic units poly(ethylene glycol) monomethyl ether (M n : 350 and 550) and a pair of hydrophobic alkyl chains (C 18 or C 15 ) via chemo-enzymatic approach. Fluorescence measurements and dynamic light scattering studies showed that all of the synthesized amphiphilic systems spontaneously self-assemble in aqueous solution, which is further confirmed by the transmission electron microscopy. Encapsulation of hydrophobic moieties like Nile red and nimodipine was studied using ultraviolet-visible (UV-vis) and fluorescence spectrometer techniques. A cytotoxicity study of the amphiphiles using A549, HeLa, and MCF7 cell, which showed that all of the synthesized nanocarriers are well tolerated at the concentrations studied. The release profile of encapsulated Nile red in synthesized amphiphilic system was studied in the presence of the immobilized enzyme (Novozym 435).amphiphile, cytotoxicity, encapsulation, self-assembly 1 | INTRODUCTION Molecular self-assembly, the spontaneous process of forming ordered aggregates without external intervention is gaining attention by researchers from different disciplines because of its widespread applications. The phenomenon is derived mostly by various noncovalent interactions such as hydrophobic, ionic, π-π stacking, and electrostatic interaction adopting the minimal Gibbs free energy and thermodynamic stability. 1-4 The natural self-assembly phenomenon, for example, polypeptide chains folding into proteins or conformational changes of nucleic acids into their different functional forms etc, have inspired the scientific community to mimic the process using newly designed molecules. 5,6 Self-assembly of amphiphilic macromolecules provide a unique and newer opportunity for designing novel material for advanced applications in biomedicine and bionanotechnology. 7-11 Among the diverse and various promising applications of amphiphilic macromolecules, the area of drug delivery is challenging because of the limited aqueous-solubility and short circulation half-life of most clinically used drugs. [12][13][14] Carrier-mediated drug delivery not only can maximize the bioavailability but also allow targeting the active site in the body while minimizing the side effects.Amphiphiles can self-assemble into a variety of nano and microscale structures in the aqueous medium, where the majorly known 3-D structures include vesicles, micelles, and molecular gels. [15][16][17] Micelles vary in diameter in the range of 5 to 100 nm and may consist of spheres, discs, and wormlike assemblies, 18 whereas vesicles are found in hollow, spherical, and lamellar type morphologies within the diameter range of 20 nm to micrometer. 19 Since micelles formed by small molecules have simple synthesis, high loading capacity, and low toxicity, they may be able to target many cancer tissues and ensure the accumulation within the small vasculatures of tumors. 20,21 However, o...

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Section: Introductionmentioning

confidence: 95%

Fabrication of oligo‐glycerol based hydrolase responsive amphiphilic nanocarriers

Mittal

Singh

Kumar

et al. 2020

Polymers for Advanced Techs

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“…Carbohydrate-based amphiphilic architectures have been successfully synthesized and investigated as advanced nanocarriers for drug delivery applications. 48,49 Carbohydrates, exhibiting a well-defined polyhydroxy architecture whose hydroxyl groups can be selectively modified, have emerged as a potential hydrophilic component for the amphiphiles. Certain advantages associated with carbohydrate-based amphiphilic architectures such as their pH independent self-assembling behaviour, biocompatibility, and mildness to the skin, make them potential candidates for drug delivery applications.…”

Section: Carbohydrate-based Amphiphiles As Drug/dye Nanocarriersmentioning

confidence: 99%

Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review

et al. 2021

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“…Sharma et al reported different types of non-ionic dendritic architectures for drug delivery applications. [60][61][62] In one of their work, they reported small non-ionic dendritic amphiphiles (7a and 7b) possessing polyglycerol G2 dendron as hydrophilic unit and C 10 and C 18 alkyl chains as hydrophobic tails. 63 These amphiphiles exhibited low CMC in the order of 10 À5 M and hydrodynamic diameters in the range of 8-10 nm, with the nano-transporters 7a and 7b possessing the highest (Fig.…”

Section: Dendritic Amphiphilesmentioning

confidence: 99%

Non-ionic small amphiphile based nanostructures for biomedical applications

et al. 2020

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Dendrimer-based micelles as cyto-compatible nanocarriers

Abstract: The aim of the present study is to compare the synthesized dendritic architectures in terms of self-assembly and transport potential for hydrophobic guest molecules.

Cited by 16 publications

References 35 publications

Fabrication of oligo‐glycerol based hydrolase responsive amphiphilic nanocarriers

Fabrication of oligo‐glycerol based hydrolase responsive amphiphilic nanocarriers

Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review

Non-ionic small amphiphile based nanostructures for biomedical applications

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