Dendrimer as nanocarrier for drug delivery

Kesharwani, Prashant; Jain, Keerti; Jain, Narendra Kumar

doi:10.1016/j.progpolymsci.2013.07.005

Cited by 912 publications

(492 citation statements)

References 229 publications

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“…The multivalent and multifunctional surface and the monodispersed and small size of dendrimers result in cooperative binding with different drugs and biological membranes, allowing their use as permeability Tomalia et al 1985 Monodispersed and controlled size in the range of nanometers Tomalia et al 1990 Multivalent, multifunctional and highly branched structure Kesharwani et al 2014 Controlled number, type and charge of surface groups Madaan et al 2015 Extremely high area/volume ratio Tomalia et al 1985 High chemical reactivity and water solubility Tomalia et al 1990 Applications Reference…”

Section: Dendrimersmentioning

confidence: 99%

“…Controlled drug delivery and tissue targeted therapy Kesharwani et al 2014 Penetration enhancers Yang et al 2013 In vitro gene transfection and in vivo gene therapy Yang et al 2015 Additives in the pharmaceutical and cosmetic industries Ammala et al 2013 Medical imaging and early diagnostics Qiao et al 2015 Analytical sensors and chelating agent of metals Hasanzadeh et al 2014 Antimicrobial and antiviral properties Reddy and Babu 2016 Anti-inflammatory properties Neibert et al 2013 enhancers. In addition, the core-shell architecture of dendrimers facilitates host-guest entrapment, allowing their use as drug delivery systems.…”

Section: Dendrimersmentioning

confidence: 99%

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Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos. In this review, we describe the toxicity of different micro-and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effects. The review also discusses the correlation of the effects of the different nanoparticles on zebrafish. Special focus is made on morphological abnormalities, altered development and abnormal behavior. The last part of the review debates changes that should be made in future directions in order to improve the use of the zebrafish model to assess nanotoxicity.

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Section: Dendrimersmentioning

confidence: 99%

Section: Dendrimersmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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“…They have improved physicochemical properties based on biocompatible and biodegradable polymers. Uniform size with low polydispersity, stability, versatile ability for modifications, and amine group-transfection ability enhances their carrier properties [44,54]. However, the complex formulations with multifaceted steps to access the core and build branches are limiting factors.…”

Section: Aerosolized Delivery Strategies For Macromolecule Drug Deliverymentioning

confidence: 99%

Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies

Osman

Kaneko

Carini

et al. 2018

Expert Opinion on Drug Delivery

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Introduction: Macromolecules with unique effects and potency are increasingly being considered for application in lung pathologies. Numerous delivery strategies for these macromolecules through the lung have been investigated to improve the targeting and overall efficacy.Areas covered: Targeting approaches from delivery devices, formulation strategies and specific targets are discussed.Expert opinion: Although macromolecules are a heterogeneous group of molecules, a number of strategies have been investigated at the macro, micro, and nanoscopic scale for the delivery of macromolecules to specific sites and cells of lung tissues. Targeted approaches are already in use at the macroscopic scale through inhalation devices and formulations, but targeting strategies at the micro and nanoscopic scale are still in the laboratory stage. The combination of controlling lung deposition and targeting after deposition, through a combination of targeting strategies could be the future direction for the treatment of lung pathologies through the pulmonary route.

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“…Owing to the unique properties, dendritic polymers (such as polyether dendrimers, polyester dendrimers, polypeptide dendrimers and PAMAM dendrimers) have been explored extensively as drug delivery carriers. [77] Among these dendritic polymers, cationic PAMAM dendrimers are the most widely studied and able to deliver chemical drugs and also genes. [78] PEGylation is a common and effective strategy for fabrication of PAMAM-based drug/gene co-delivery systems.…”

Section: Poly(amido Amine) (Pamam) Dendrimer-based Nanoparticlesmentioning

confidence: 99%

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

Thambi

Lee

2017

Adv Healthcare Materials

100

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Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory treatment effect. Therefore, co‐delivery of dual drugs or co‐delivery of a drug and a gene in a polymeric nanoparticle has attracted attention. Such co‐delivery systems can overcome multi‐drug resistance of chemical drugs and achieve a synergistic therapeutic effect. In this progress report, we summarize recent progress in the preparation and application of polymeric drug and gene co‐delivery nanosystems. The remaining challenges and future trends in this field are also included.

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Dendrimer as nanocarrier for drug delivery

Cited by 912 publications

References 229 publications

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies

Co‐Delivery of Drugs and Genes Using Polymeric Nanoparticles for Synergistic Cancer Therapeutic Effects

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