Demonstration of silicon in sites of connective-tissue disease in patients with silicone-gel breast implants

Silver, R. M.

doi:10.1001/archderm.129.1.63

Cited by 30 publications

(13 citation statements)

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“…Silicone is hydrophobic, and as microdroplets, it does not migrate easily through an aqueous environment. The way for this free silicone to move in the body is then to be picked up by macrophages (5). Therefore, it is not surprising to identify silicone in lymph nodes and in surrounding tissues in patients with breast prostheses (6).…”

Section: Introductionmentioning

confidence: 99%

High resolution solid‐state ²⁹si nmr spectroscopy of silicone gels used to fill breast prostheses

Dorne¹,

Alikacem²,

Guidoin³

et al. 1995

Magnetic Resonance in Med

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We have used 29Si solid-state nuclear magnetic resonance (NMR) spectroscopy to study the chemical structure of the silicone gels in virgin and explanted breast prostheses. Despite evidences of alteration in the morphological appearance of the silicone gel inside the breast prosthesis, our results do not reveal changes in the chemical nature and structure of the silicone gels after implantation. In addition to the main 29Si resonance peak at -22.26 ppm that corresponds to the resonance frequency of the D repeat unit of the polysiloxane chains, the high sensitivity of our NMR technique allows the detection of very low concentrations of silicone compounds. Within our experimental detection limit of 0.2%, no signal between -90 ppm and -150 ppm are observed. This indicates that no silica products are present inside the gel of the prostheses. Furthermore, our 29Si NMR spectra indicate differences in the chemical compositions of the silicone gels from different manufacturers.

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Section: Introductionmentioning

confidence: 99%

High resolution solid‐state ²⁹si nmr spectroscopy of silicone gels used to fill breast prostheses

Dorne¹,

Alikacem²,

Guidoin³

et al. 1995

Magnetic Resonance in Med

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“…Electron probe microanalysis showed that these particles were high in silicon. This suggested that sil icon-containing material not only spreads to distant sites, including those affected by connective tissue disease, but also suggested a link between ongoing dissemination of sil icon-containing material and inflammatory reactions [13]. In our patient, there was no evidence by light microscopy of foreign material in the granulomas biopsied from sites other than the breast implant capsule.…”

Section: Discussionmentioning

confidence: 49%

Remission of Sarcoidosis following Removal of Silicone Gel Breast Implants

Teuber

Howell²,

Yoshida

et al. 1994

Int Arch Allergy Immunol

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We report herein a patient with debilitating multisystem sarcoidosis. Interestingly, dermal lesions and enlarged lymph nodes resolved and her clinical condition dramatically improved following removal of silicone gel breast implants. Of note, the capsular tissue surrounding the breast implant demonstrated a granulomatous foreign-body response. The potential harmful effects of silicone may include an acceleration of an already existing hypersensitivity response.

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“…These pathologies include acute inflammation, granuloma formation, immune adjuvancy, and particle dissemination. 5,7,9,10,13,[17][18][19][20]29 Because fibrinogen has been shown to act synergistically with the surface of other hydrophobic microparticulates to elicit these pathologies, 19,20 it seems reasonable to assume the same synergy operates in the case of yet another hydrophobic material, that is, of PDMS.…”

Section: Discussionmentioning

confidence: 99%

“…Our attention now is focused on dissemination of PDMS droplets from sites of implantation of bulk phase polymer. 5,16,29 Our working hypothesis is that fibrin strands serve as ''tethers'' between droplets and cells, and these tethers facilitate the intracellular and/or extracellular transport of droplets by cells. Using fibrinogen-deficient mice and various antiadhesive agents, we now are testing this and other hypotheses relating fibrinogen to the inflammation Figure 6.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable

Whitlock

Clarson

Retzinger

1999

J. Biomed. Mater. Res.

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Fibrinogen binds from aqueous media containing it to droplets of linear trimethylsilyl-terminated poly(dimethylsiloxane) (PDMS) dispersed in those same media. Once bound, fibrinogen elutes from emulsified droplets of PDMS only very slowly, even when incubated in buffer that contains a physiologic concentration of the protein. The bound fibrinogen is coagulable, as indicated by the thrombin-dependent agglutination of droplets. Thus fibrinogen bound to droplets of PDMS renders an adhesive potential to the surface of the droplets, a potential that may have relevance to the biologic processing of the polymer in vivo.

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Demonstration of silicon in sites of connective-tissue disease in patients with silicone-gel breast implants

Cited by 30 publications

References 0 publications

High resolution solid‐state ²⁹si nmr spectroscopy of silicone gels used to fill breast prostheses

High resolution solid‐state ²⁹si nmr spectroscopy of silicone gels used to fill breast prostheses

Remission of Sarcoidosis following Removal of Silicone Gel Breast Implants

Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable

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Demonstration of silicon in sites of connective-tissue disease in patients with silicone-gel breast implants

Cited by 30 publications

References 0 publications

High resolution solid‐state 29si nmr spectroscopy of silicone gels used to fill breast prostheses

High resolution solid‐state 29si nmr spectroscopy of silicone gels used to fill breast prostheses

Remission of Sarcoidosis following Removal of Silicone Gel Breast Implants

Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable

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High resolution solid‐state ²⁹si nmr spectroscopy of silicone gels used to fill breast prostheses

High resolution solid‐state ²⁹si nmr spectroscopy of silicone gels used to fill breast prostheses