Demonstration of atomic force microscopy imaging using an integrated opto-electro-mechanical transducer

Galeotti, Federico; Lindgren, Gustav; Petruzzella, Maurangelo; Otten, F. W. M. van; Marnani, H. Sadeghian; Mohtashami, Abbas; Heijden, Rob van der; Fiore, Andrea

doi:10.1016/j.ultramic.2021.113368

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…High-speed scanning AFM reduces testing time through enhanced scanning speed (Liao et al, 2022). The miniaturized and integrated sensing mechanism of the AFM parallel scanning probe system enables simultaneous operation of multiple probes for image acquisition (Galeotti et al, 2021). Additionally, a fully automated multi-sample analysis concept facilitates the study of samples in fluids and biological cells by increasing the number of scanned samples (Dujardin et al, 2019).…”

Section: Discussion and Prospectmentioning

confidence: 99%

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

Liu,

Han,

Kong

et al. 2023

Microscopy Res & Technique

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Despite significant progress in human medicine, certain diseases remain challenging to promptly diagnose and treat. Hence, the imperative lies in the development of more exhaustive criteria and tools. Tissue and cellular mechanics exhibit distinctive traits in both normal and pathological states, suggesting that “force” represents a promising and distinctive target for disease diagnosis and treatment. Atomic force microscopy (AFM) holds great promise as a prospective clinical medical device due to its capability to concurrently assess surface morphology and mechanical characteristics of biological specimens within a physiological setting. This review presents a comprehensive examination of the operational principles of AFM and diverse mechanical models, focusing on its applications in investigating tissue and cellular mechanics associated with prevalent diseases. The findings from these studies lay a solid groundwork for potential clinical implementations of AFM.Research HighlightsBy examining the surface morphology and assessing tissue and cellular mechanics of biological specimens in a physiological setting, AFM shows promise as a clinical device to diagnose and treat challenging diseases.

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Section: Discussion and Prospectmentioning

confidence: 99%

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

Liu,

Han,

Kong

et al. 2023

Microscopy Res & Technique

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“…They are mainly focused on sensing displacement, mass [10], or force [11] as a consequence of the target phenomena such as molecular bindings, mechanical vibrations, or external stress. As an example, MOEMS and NOEMS are present in devices such as atomic force microscopes [12], accelerometers [13], or biosensors [14]. Current trends show that optical solutions provide a better performance in terms of sensitivity, resolution, and power consumption compared to other sensing methods (e.g., piezoelectric or capacitive) [15].…”

Section: Introductionmentioning

confidence: 99%

All-Optical Nanosensor for Displacement Detection in Mechanical Applications

et al. 2022

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In this paper, we propose the design of an optical system based on two parallel suspended silicon nanowires that support a range of optical resonances that efficiently confine and scatter light in the infrared range as the base of an all-optical displacement sensor. The effects of the variation of the distance between the nanowires are analyzed. The simulation models are designed by COMSOL Multiphysics software, which is based on the finite element method. The diameter of the nanocylinders (d = 140 nm) was previously optimized to achieve resonances at the operating wavelengths (λ = 1064 nm and 1310 nm). The results pointed out that a detectable change in their resonant behavior and optical interaction was achieved. The proposed design aims to use a simple light source using a commercial diode laser and simplify the readout systems with a high sensitivity of 1.1 × 106 V/m2 and 1.14 × 106 V/m2 at 1064 nm and 1310 nm, respectively. The results may provide an opportunity to investigate alternative designs of displacement sensors from an all-optical approach and explore their potential use.

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Integrated Photonic Optomechanical Atomic Force Microscopy Probes Batch Fabricated Using Deep UV Photolithography

Perez-Morelo

Wang

Madhaven³

et al. 2023

J. Microelectromech. Syst.

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Demonstration of atomic force microscopy imaging using an integrated opto-electro-mechanical transducer

Cited by 3 publications

References 34 publications

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

All-Optical Nanosensor for Displacement Detection in Mechanical Applications

Integrated Photonic Optomechanical Atomic Force Microscopy Probes Batch Fabricated Using Deep UV Photolithography

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