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Cited by 1,430 publications
(1,367 citation statements)
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References 174 publications
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“…Inhibitory IRS1pSer can block downstream insulin signaling (Zhao et al ., 2008b). Furthermore, the levels of p‐IRS1 (pS636) and p‐IRS1 (pS612) are positively correlated with Aβ plaques and negatively associated with episodic and working memory (Talbot et al ., 2012). In this study, we found significantly increased p‐IRS1 (pS636) and p‐IRS1 (pS612) in vehicle‐treated transgenic mice; these are considered a key signature of insulin resistance (Talbot et al ., 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Inhibitory IRS1pSer can block downstream insulin signaling (Zhao et al ., 2008b). Furthermore, the levels of p‐IRS1 (pS636) and p‐IRS1 (pS612) are positively correlated with Aβ plaques and negatively associated with episodic and working memory (Talbot et al ., 2012). In this study, we found significantly increased p‐IRS1 (pS636) and p‐IRS1 (pS612) in vehicle‐treated transgenic mice; these are considered a key signature of insulin resistance (Talbot et al ., 2012).…”
Section: Discussionmentioning
confidence: 99%
“…In fact, brain insulin resistance develops before the onset of AD symptoms [47]. Brain tissues require a high level of glucose energy intake (about 20%) in humans and mammals and brain energy deficiency might be a contributing factor of abnormal brain function in AD [112].…”
Section: Methods Of Treating Alzheimer's Disease and Type 2 Diabetesmentioning
confidence: 99%
“…Some researchers have proclaimed that AD is really a form of “Type 3 Diabetes” [46]. Insulin resistance in the brain typically precedes and contributes to cognitive decline above and beyond other known causes of AD [47] and abnormalities in the activity of two major signaling pathways for insulin and insulin-like growth factor in non-diabetic people with AD has been identified [48]. Thus, brain insulin resistance appears to be an early and common feature of AD.…”
Section: Pathophysiologymentioning
confidence: 99%
“…For example, reduced insulin, insulin receptor, IGF1 and IGF2, reduced total IRS1 mRNA expression, and reduced protein indicators of downstream insulin signaling activity (including p85‐associated IRS1, phosphorylated AKT) have been reported in postmortem AD brain (Steen et al, 2005). Although there are some controversial results about insulin receptor concentration, insulin resistance in AD has been demonstrated a novel ex vivo insulin signaling stimulation experiment (Arnold et al, 2018; Talbot et al, 2012). Insulin may affect Aβ degradation via an insulin‐degrading metalloprotease.…”
Section: Lifestyle Associations and Interventions For Aging And Admentioning
confidence: 99%