Demographic and clinical characteristics of patients with type 1 diabetes mellitus: A multicenter registry study in Guangdong, China

Yang, Daizhi; Deng, Hongrong; Luo, Guo-chun; Wu, Ge; Lin, Shaoda; Lin, Yuan; Xv, Meilun; Li, Shaoqing; Zhang, Xiuwei; Jian-hua, WU; Lang, Jiang-ming; Liang, Ganxiong; Jiang, Lin; Chen, Dingyu; Li, Lü; Fang, Yi-shan; Yongxin, Wu; Ou, Wei; Li, Jin; Weng, Jianping; Yan, Jinhua

doi:10.1111/1753-0407.12366

Cited by 21 publications

(26 citation statements)

References 33 publications

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“…The inclusion criteria and detailed protocol were described in our previous studies. 18 The study protocols were approved by the ethics committee of the Third Affiliated Hospital of Sun Yat-sen University. All adult participants provided written informed consent.…”

Section: Participantsmentioning

confidence: 99%

Current status of metformin in addition to insulin therapy in adult patients with type 1 diabetes mellitus: An analysis from the Guangdong Type 1 Diabetes Mellitus Translational Medicine Study

Qiu

Ling

Yang

et al. 2020

Journal of Diabetes

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Background Limited data on the efficacy of the additional metformin therapy in patients with type 1 diabetes mellitus (T1DM) under real‐life conditions have been available so far. Methods Patients aged ≥18 years with a duration of T1DM for at least 1 year were included in this multicenter observational study. Patients with insulin combined with metformin therapy (MET group) were compared with those with insulin therapy only (INS group). Results A total of 76 patients in the MET group were compared with 655 patients in the INS group. At baseline, patients with dyslipidemia were more prevalent in the MET group (17.6% vs 9.0%; P = .006), and they also had a higher body mass index (BMI) (21.7 ± 3.2 kg/m2 vs 20.4 ± 2.6 kg/m2; P < .001) than those in the INS group. But glycosylated hemoglobin (HbA1c) and daily insulin dose were not significantly different between the two groups. After 1‐year follow‐up, HbA1c decreased in both groups, while the daily insulin dose decreased in the MET group, but did not change in the INS group (−0.02 IU/kg [−0.16, 0.09] vs 0 IU/kg [−0.09, 0.09]; P = .029). The additional metformin therapy led to no change of BMI and weight in the MET group, while the body weight increased from 53.7 ± 8.6 kg to 55.0 ± 7.9 kg in the INS group (P < .001). Conclusions Metformin is initiated more in T1DM patients with dyslipidemia or higher BMI in current practice in China. The addition of metformin is effective in maintaining weight and reducing the insulin dosage without improving glycemic control in patients with T1DM.

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Section: Participantsmentioning

confidence: 99%

Current status of metformin in addition to insulin therapy in adult patients with type 1 diabetes mellitus: An analysis from the Guangdong Type 1 Diabetes Mellitus Translational Medicine Study

Qiu

Ling

Yang

et al. 2020

Journal of Diabetes

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“…7 8 Our previous study also indicated that the onset of type 1 diabetes in adulthood is not rare in China. 9 Yet little is known about its incidence in adults aged more than 20 years. 10 …”

Section: Introductionmentioning

confidence: 99%

Incidence of type 1 diabetes in China, 2010-13: population based study

Weng¹,

Zhou²,

Guo³

et al. 2018

BMJ

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223

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ObjectiveTo estimate the incidence of type 1 diabetes in all age groups in China during 2010-13.DesignPopulation based, registry study using data from multiple independent sources.SettingNational registration system in all 505 hospitals providing diabetes care, and communities of patients with diabetes in 13 areas across China, covering more than 133 million person years at risk, approximately 10% of the whole population.Participants5018 people of all ages with newly diagnosed type 1 diabetes and resident in the study areas from 1 January 2010 to 31 December 2013.Main outcome measuresIncidence of type 1 diabetes per 100 000 person years by age, sex, and study area. Type 1 diabetes was doctor diagnosed and further validated by onsite follow-up. Completeness of case ascertainment was assessed using the capture mark recapture method.Results5018 cases of newly diagnosed type 1 diabetes were ascertained: 1239 participants were aged <15 years, 1799 were aged 15-29 years, and 1980 were aged ≥30 years. The proportion of new onset cases in participants aged ≥20 years was 65.3%. The estimated incidence of type 1 diabetes per 100 000 persons years for all ages in China was 1.01 (95% confidence interval 0.18 to 1.84). Incidence per 100 000 persons years by age group was 1.93 (0.83 to 3.03) for 0-14 years, 1.28 (0.45 to 2.11) for 15-29 years, and 0.69 (0.00 to 1.51) for ≥30 years, with a peak in age group 10-14 years. The incidence in under 15s was positively correlated with latitude (r=0.88, P<0.001), although this association was not observed in age groups 15-29 years or ≥30 years.ConclusionMost cases of new onset type 1 diabetes in China occurred among adults. The incidence of type 1 diabetes in Chinese children was among the lowest reported in the study.

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“…The Guangdong Type 1 Diabetes Mellitus translational study (GTT study) was a prospective multicentre hospital-based register study, conducted in 16 tertiary hospitals throughout 12 cities of Guangdong, China. The inclusive criteria and detailed protocols have been reported previously [8,9]. Newly diagnosed and priorly diagnosed patients with T1DM who visited the participating hospitals consecutively from June 2011 to July 2018 and finished at least one-year follow-up were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Those who were compatible with the last two criteria but had the duration of the disease before the start of insulin treatment for more than one to two weeks were highly suspected and also assigned into the FT1DM group. Typical type 1 diabetes was defined as follows [8]:…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics of Fulminant Type 1 Diabetes Compared with Typical Type 1 Diabetes: One-Year Follow-Up Study from the Guangdong T1DM Translational Medicine Study

Yang

Zhou

Luo

et al. 2020

Journal of Diabetes Research

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Background. Fulminant type l diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus (T1DM) with abrupt onset, but data on its progression was limited. This study was aimed at exploring the clinical features through one-year follow-up. Methods and Materials. Patients with T1DM finishing at least one-year follow-up from June 2011 to July 2018 were enrolled from Guangdong Type 1 Diabetes Translational Medicine Study. Patients who fulfilled the respective criteria were categorized as an FT1DM group and a typical T1DM group (TT1DM). The 1 : 4 propensity score matching based on onset age, duration, and gender was performed between the FT1DM and TT1DM groups. Characteristics at the onset and after one-year follow-up were compared between the two groups. Results. A total of 53 patients with FT1DM and 212 matched patients with TT1DM were included. At the onset, there was a shorter duration of symptomatic period before diagnosis observed in the FT1DM group than in the TT1DM group (2 [1, 7] vs. 30 [10, 60] days, P<0.001). FT1DM patients had higher plasma glucose levels and higher percentage of diabetes ketoacidosis (P<0.001, respectively). Both fasting and postprandial C-peptide levels (FCP and PCP, respectively) in FT1DM were significantly lower (P<0.001). At enrollment, the duration of diabetes was 0.03 (0.00, 0.81) and 0.07 (0.00, 1.11) years and the level of HbA1c was 7.21±1.56% and 10.06±3.23% (P<0.001) in the FT1DM and TT1DM groups, respectively. After one year, both FCP and PCP were still significantly lower in the FT1DM group (P<0.001, 0.022) and the HbA1c level was similar between the two groups (P=0.128). The level of HDL-C in FT1DM was significantly higher than that in the TT1DM group at enrollment (P=0.019), and the change from enrollment was significantly greater than that in the FT1DM group (P=0.042). Conclusion. Patients with FT1DM had more severe metabolic derangement and deficiency of insulin secretion than patients with TT1DM at the onset, but glycaemic and metabolic control was not worse than that in TT1DM.

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Demographic and clinical characteristics of patients with type 1 diabetes mellitus: A multicenter registry study in Guangdong, China

Cited by 21 publications

References 33 publications

Current status of metformin in addition to insulin therapy in adult patients with type 1 diabetes mellitus: An analysis from the Guangdong Type 1 Diabetes Mellitus Translational Medicine Study

Current status of metformin in addition to insulin therapy in adult patients with type 1 diabetes mellitus: An analysis from the Guangdong Type 1 Diabetes Mellitus Translational Medicine Study

Incidence of type 1 diabetes in China, 2010-13: population based study

Clinical Characteristics of Fulminant Type 1 Diabetes Compared with Typical Type 1 Diabetes: One-Year Follow-Up Study from the Guangdong T1DM Translational Medicine Study

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