Demodex granuloma

Ecker, R. I.

doi:10.1001/archderm.115.3.343

Cited by 19 publications

(13 citation statements)

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“…More recently, Grosshans et al [4], Ecker and Winkelmann [6], and Rufliet al [8] found extrafollicular gran ulomas containing Demodex parts sur rounded by a mantle of lymphohistiocytic infiltrates.…”

Section: Commentmentioning

confidence: 99%

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T-Cell Subsets in Acne rosacea Lesions and the Possible Role of Demodex folliculorum

Rufli¹,

Büchner²

1984

Dermatology

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Skin biopsy specimens from 4 patients with typical acne rosacea lesions were examined for the presence of T-cell subsets using monoclonal antibodies. The infiltrates consisted chiefly of LEU-1 reactive T cells with a predominance of LEU-3a antibody positive helper-inducer T cells, while LEU-2a staining suppressor-cytotoxic T cells were scarce. These cells penetrated regularly into the follicular wall and the epidermis. The study showed that most T cells in the dermal granulomatous infiltrates around Demodex parts, which were displaced extrafoUicularly, were helper-inducer T cells. The predominance of helper-inducer T-cell subsets in the dermal infiltrates of acne rosacea lesions in frequent association with Demodex supports the hypothesis that a cell-mediated immune response plays an important role in the pathogenesis of rosacea.

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Section: Commentmentioning

confidence: 99%

“…On the other hand, several authors [4][5][6][7][8] found Demodices in the center of tubercu loid granulomas that were preferential ly composed of lymphocytes and plasma cells.…”

Section: Introductionmentioning

confidence: 99%

T-Cell Subsets in Acne rosacea Lesions and the Possible Role of Demodex folliculorum

Rufli¹,

Büchner²

1984

Dermatology

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“…Seifert [1978] observed a solitary Demodex granuloma in a 9-year-old boy. Ecker and Winkelmann [1979] reported on an extensive perioral granu lomatosis in a 50-year-old woman. Histology disclosed a lymphohistiocytic infiltrate with foreign body giant cells in the upper dermis and an extrafolli cular intact adult D. folliculorum in the area of pronounced granulomatous infiltration, a picture consistent with granulomatous rosacea.…”

Section: Clinical Importancementioning

confidence: 99%

The Hair Follicle Mites Demodex folliculorum and Demodex brevis: Biology and Medical Importance

Rufli

Mumcuoglu²

1981

Dermatology

182

138

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“…The mite population increases with host age, and in the adult population, these two Demodex species parasitize the normal skin with a prevalence of 100% and a usual density <5 mites/cm 2 . Demodex mites are usually considered to play a pathogenic role when present in an excessive number or penetrating into the dermis (Ayres and Ayres, 1961;Ecker and Winkelmann, 1979;Bonnar et al, 1993;Forton and Seys, 1993;Erbagci and Ozgoztasi, 1998). They have been implicated in the occurrence of a wide range of clinical features, including pityriasis folliculorum (Ayres and Ayres, 1961), papulopustular and granulomatous rosacea (Bonnar et al, 1993;Forton and Seys, 1993), inflammatory papule (Seifert, 1978), folliculitis (Purcell et al, 1986), seborrheic dermatitis (Karincaoglu et al, 2009), perioral dermatitis (Dolenc-Voljc et al, 2005), and blepharitis (Post and Juhlin, 1963;Zhao et al, 2011a), although much controversy persists (Bonnar et al, 1993;Forton and Seys, 1993;Forton et al, 2005;Hsu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Facial dermatosis associated with Demodex: a case-control study

Zhao

Yan

Wang

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:Demodex has been considered to be related with multiple skin disorders, but controversy persists. In this case-control study, a survey was conducted with 860 dermatosis patients aged 12 to 84 years in Xi'an, China to identify the association between facial dermatosis and Demodex. Amongst the patients, 539 suffered from facial dermatosis and 321 suffered from non-facial dermatosis. Demodex mites were sampled and examined using the skin pressurization method. Multivariate regression analysis was applied to analyze the association between facial dermatosis and Demodex infestation, and to identify the risk factors of Demodex infestation. The results showed that total detection rate of Demodex was 43.0%. Patients aged above 30 years had higher odds of Demodex infestation than those under 30 years. Compared to patients with neutral skin, patients with mixed, oily, or dry skin were more likely to be infested with Demodex (odds ratios (ORs) were 2.5, 2.4, and 1.6, respectively). Moreover, Demodex infestation was found to be statistically associated with rosacea (OR=8.1), steroid-induced dermatitis (OR=2.7), seborrheic dermatitis (OR=2.2), and primary irritation dermatitis (OR=2.1). In particular, ORs calculated from the severe infestation (≥5 mites/cm 2 ) rate were significantly higher than those of the total rate. Therefore, we concluded that Demodex is associated with rosacea, steroid-induced dermatitis, seborrheic dermatitis, and primary irritation dermatitis. The rate of severe infestation is found to be more correlated with various dermatosis than the total infestation rate. The risk factors of Demodex infestation, age, and skin types were identified. Our study also suggested that good hygiene practice might reduce the chances of demodicosis and Demodex infestation.

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Demodex granuloma

Cited by 19 publications

References 0 publications

T-Cell Subsets in Acne rosacea Lesions and the Possible Role of <i>Demodex folliculorum</i>

T-Cell Subsets in Acne rosacea Lesions and the Possible Role of <i>Demodex folliculorum</i>

The Hair Follicle Mites <i>Demodex folliculorum</i> and <i>Demodex brevis</i>: Biology and Medical Importance

Facial dermatosis associated with Demodex: a case-control study

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