Demineralization in Cystic Fibrosis

Abstract

\s=b\ Bone mineral content, bone width, and their ratio were measured in patients with cystic fibrosis (CF) using monoenergetic photon absorptiometry. Serial measurements of the radius and ulna were made in 27 patients with CF and were compared with 968 age-matched controls.Demineralization was found in 37% of the boys and 63% of the girls. Patients under age 10 years had normal bone mineral content and nine of 15 patients aged 13 or older were demineralized (P < .01). Demineralization correlated with the extent of weight reduction in patients (P < .001). Patients most likely to be demineralized were adolescent girls. To our knowledge, this is the first report of bone mineral status of children with CF, and the results indicate that a sizable proportion of these patients may be demineralized without overt rickets.

Low Serum Bone Gamma-Carboxyglutamic Acid Protein Concentrations in Patients with Cystic Fibrosis: Correlation with Hormonal Parameters and Bone Mineral Density

“…An important osteo penia (BMD < 2 SD of mean for age) was found in 19% of the studied CF population. This is in accordance with the frequency of osteopenia in CF found in other studies using different techniques [20,21]. Since 5 patients of the 13 with a decreased BGP concentration presented a decreased BMD, BGP measurement in our study had as screening method for vertebral osteopenia a sensitivity of 83%, but yielded only a specificity of 72%.…”

Correlates of prepubertal bone mineral density in cystic fibrosis

“…9 21 Bone mineralisation studies in prepubertal children with CF have, however, been less consistent. Gibbens and colleagues,2 using quantitative computed tomography, and Bhudikanok and colleagues,22 using dual energy radiographic absorptiometry have shown demineralisation in this population, in contrast to the findings of Solomons and colleagues23 and Mischler and colleagues 24. The present study found total body BMD to be distributed in the normal range.…”

Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors

“…Children with CF may fail to reach their peak bone mass,3 4 8 9 and the recognition that osteopenia is common at all ages suggests that both inadequate bone mineral accretion as well as increased bone loss are important aetiological factors. Our results support this.…”