Dementia in Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type

Microvasculopathy Is Associated With the Number of Cerebrovascular Lesions in Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type

“…26 Virtually all affected patients develop intracerebral hemorrhages and infarcts, and a substantial proportion of them develop dementia. 20,27,28 Recently, we described a high frequency of CAA-AM in patients with HCHWA-D. 17 In the present study we hypothesize an association of the severity of CAA-AM with (1) the number of cerebrovascular lesions, age at death, and duration of clinical illness and (2) systemic vascular disease in the form of hypertension and atherosclerosis. In addition, we looked for a possible association of hypertension and atherosclerosis with the total number of cerebrovascular lesions, with the age at death, and with duration of clinical illness of affected patients.…”

Microvasculopathy Is Associated With the Number of Cerebrovascular Lesions in Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type

“…26 Virtually all affected patients develop intracerebral hemorrhages and infarcts, and a substantial proportion of them develop dementia. 20,27,28 Recently, we described a high frequency of CAA-AM in patients with HCHWA-D. 17 In the present study we hypothesize an association of the severity of CAA-AM with (1) the number of cerebrovascular lesions, age at death, and duration of clinical illness and (2) systemic vascular disease in the form of hypertension and atherosclerosis. In addition, we looked for a possible association of hypertension and atherosclerosis with the total number of cerebrovascular lesions, with the age at death, and with duration of clinical illness of affected patients.…”

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies.

“…The mean age (SD) for the combined groups was 50 4 (5-6) years (median 50 years). For group A these figures were 49-8 (4)(5)(6)(7)(8) years (median 50 5 years) and for group B 514 (6&5) years (median 51 years). In the total material there was a female to male ratio of 5:4.…”

The C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene and Vascular Dementia

“…Data about genetic factors related to the risk of vascular dementia are sparse. Autosomal dominant hereditary cerebral hemorrhage with amyloidosis‐Dutch type and familial vascular encephalopathies, such as cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CASDIL), have been described but are believed to be uncommon 21–23 . It has recently been suggested that apolipoprotein E polymorphism may play a role in vascular dementia.…”

Microvasculopathy Is Associated With the Number of Cerebrovascular Lesions in Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type

“…26 Virtually all affected patients develop intracerebral hemorrhages and infarcts, and a substantial proportion of them develop dementia. 20,27,28 Recently, we described a high frequency of CAA-AM in patients with HCHWA-D. 17 In the present study we hypothesize an association of the severity of CAA-AM with (1) the number of cerebrovascular lesions, age at death, and duration of clinical illness and (2) systemic vascular disease in the form of hypertension and atherosclerosis. In addition, we looked for a possible association of hypertension and atherosclerosis with the total number of cerebrovascular lesions, with the age at death, and with duration of clinical illness of affected patients.…”

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies.

“…The mean age (SD) for the combined groups was 50 4 (5-6) years (median 50 years). For group A these figures were 49-8 (4)(5)(6)(7)(8) years (median 50 5 years) and for group B 514 (6&5) years (median 51 years). In the total material there was a female to male ratio of 5:4.…”

The C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene and Vascular Dementia

“…Data about genetic factors related to the risk of vascular dementia are sparse. Autosomal dominant hereditary cerebral hemorrhage with amyloidosis‐Dutch type and familial vascular encephalopathies, such as cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CASDIL), have been described but are believed to be uncommon 21–23 . It has recently been suggested that apolipoprotein E polymorphism may play a role in vascular dementia.…”

Microvasculopathy Is Associated With the Number of Cerebrovascular Lesions in Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type

“…26 Virtually all affected patients develop intracerebral hemorrhages and infarcts, and a substantial proportion of them develop dementia. 20,27,28 Recently, we described a high frequency of CAA-AM in patients with HCHWA-D. 17 In the present study we hypothesize an association of the severity of CAA-AM with (1) the number of cerebrovascular lesions, age at death, and duration of clinical illness and (2) systemic vascular disease in the form of hypertension and atherosclerosis. In addition, we looked for a possible association of hypertension and atherosclerosis with the total number of cerebrovascular lesions, with the age at death, and with duration of clinical illness of affected patients.…”

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies.

“…The mean age (SD) for the combined groups was 50 4 (5-6) years (median 50 years). For group A these figures were 49-8 (4)(5)(6)(7)(8) years (median 50 5 years) and for group B 514 (6&5) years (median 51 years). In the total material there was a female to male ratio of 5:4.…”

The C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene and Vascular Dementia

“…Data about genetic factors related to the risk of vascular dementia are sparse. Autosomal dominant hereditary cerebral hemorrhage with amyloidosis‐Dutch type and familial vascular encephalopathies, such as cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CASDIL), have been described but are believed to be uncommon 21–23 . It has recently been suggested that apolipoprotein E polymorphism may play a role in vascular dementia.…”