Delusional Disorder Molecular Genetic Evidence for Dopamine Psychosis

Morimoto, Kiyoshi; Miyatake, Ryosuke; Nakamura, Mitsuo; Watanabe, Takemi; Hirao, Toshihide; Sekiya, Hiroshi

doi:10.1016/s0893-133x(01)00421-3

Cited by 51 publications

(31 citation statements)

References 60 publications

(43 reference statements)

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“…Apart from these localizationist hypotheses, some authors have argued that the cause of paranoid symptoms is a hyperdopaminergic state in the brain [57]. Specifically, it has been proposed that these patients may have a hyperreactive dopamine system [58].…”

Section: Theories On Delusionsmentioning

confidence: 99%

Neuropsychological Research in Delusional Disorder: A Comprehensive Review

Ibanez-Casas

Cervilla

2012

Psychopathology

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In recent decades, there has been a growing interest in the field of delusions, and different aspects of delusional disorder (DD) have been investigated. However, DD is still one of the most underresearched psychiatric disorders. In this paper, we review the literature on DD and most of the theoretical approaches proposed to explain the development and maintenance of delusions. DD research is infrequent, and delusions in this disorder have been scarcely investigated. We aim to establish the state of the art of delusions research to date and point to the shortage of neuropsychological studies in patients with DD. We also justify the need for future research into the neuropsychological correlates of DD as measured in patients with this disorder given that most previous research has mainly focused on other psychotic conditions.

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Section: Theories On Delusionsmentioning

confidence: 99%

Neuropsychological Research in Delusional Disorder: A Comprehensive Review

Ibanez-Casas

Cervilla

2012

Psychopathology

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“…According to the inclusion criteria, 16 studies with full texts were included in this meta-analysis (Itokawa et al, 1993;Hattori et al, 1994;Nanko et al, 1994;Arinami et al, 1994Arinami et al, , 1996Chen et al, 1996;Ohara et al, 1996;Tanaka et al, 1996;Fujiwara et al, 1997;Harano, 1997;Kaneshima et al, 1997;Hori et al, 2001;Himei et al, 2002;Morimoto et al, 2002;Gupta et al, 2009;Fan et al, 2010) and 224 studies were excluded. The flow chart of study selection is summarized in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Association between Ser311Cys polymorphism in the dopamine D2 receptor gene and schizophrenia risk: a meta-analysis in Asian populations

Liu¹,

Liu²,

An³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between Ser311Cys (rs1801028, C>G) polymorphism of the dopamine D2 receptor (DRD2) gene and schizophrenia risk. However, the specific association is still controversial. We examined whether DRD2 Ser311Cys polymorphism confers schizophrenia risk in Asian popu- lations. Sixteen studies were retrieved reporting on a total of 2268 schizophrenia patients and 2423 healthy controls. Meta-analysis of the results showed significant associations between Ser311Cys polymorphism and schizophrenia risk in the comparisons of G versus C (odds ratio (OR) = 1.47, 95% confidence interval (CI) = 1.18-1.83, P = 0.0006) and CG+GG versus CC (OR = 1.45, 95%CI = 1.16-1.82, P = 0.001). In a subgroup analysis by nationality, we found a significant association between Ser311Cys polymorphism and schizophrenia risk in the comparisons of G versus C and CG+GG versus CC genotype in the Japanese population (OR = 1.75, 95%CI = 1.30-2.35, P = 0.0002; OR = 1.72, 95%CI = 1.27-2.33, P = 0.0004; respectively) but not in Chinese and Indian populations. In conclusion, the G allele of DRD2 Ser311Cys polymorphism involves a potential risk factor for schizophrenia in Asian populations, especially in the Japanese population.

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“…A small number of association studies have been performed, based on a functional rather than a positional approach. A polymorphism in the dopamine D3 receptor gene (DRD3) has shown association with delusional disorder in one study [138], but not in another [139]. A polymorphism in the dopamine D4 receptor gene (DRD4) has also been associated with delusional disorder in one study [140].…”

Section: Other Psychotic Disordersmentioning

confidence: 93%

Genetics of Schizophrenia and other Psychotic Disorders

Pepper¹,

Cardno²

2014

CPSR

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Abstract:Research into the genetic basis of schizophrenia is advancing rapidly. This review gives a broad overview of results from successive phases of studies in this field, linking these with recent findings and likely future research directions. Among recent findings, large-scale epidemiological studies based on Scandinavian population registers, have provided further evidence of substantial heritability and evidence that a wide range of psychotic and non-psychotic disorders partly share genetic risk factors with schizophrenia. In molecular genetics, large collaborative genomewide association studies (GWAS) are providing evidence of common risk variants, each of small effect, and many more variants are likely to be found as samples sizes increase further. A range of rarer chromosomal copy number variants (CNVs) have been associated with schizophrenia, and both GWAS and CNV studies have provided molecular evidence of genetic overlap between schizophrenia and other disorders. There is increasing interest in phenotypes beyond diagnosis, including further clinical variables and endophenotypes. Next-generation sequencing studies are beginning, with the potential for fast, inexpensive sequencing of the whole genome in large samples, and there is an increasing focus on the functional effects of the candidate risk variants that are being identified.

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Delusional Disorder Molecular Genetic Evidence for Dopamine Psychosis

Cited by 51 publications

References 60 publications

Neuropsychological Research in Delusional Disorder: A Comprehensive Review

Neuropsychological Research in Delusional Disorder: A Comprehensive Review

Association between Ser311Cys polymorphism in the dopamine D2 receptor gene and schizophrenia risk: a meta-analysis in Asian populations

Genetics of Schizophrenia and other Psychotic Disorders

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