Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway

Hou, De‐Xing; Tong, Xuhui; Terahara, Norihiko; Luo, Dong; Fujii, Makoto

doi:10.1016/j.abb.2005.06.002

Cited by 138 publications

(98 citation statements)

References 39 publications

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“…46 A dose-dependent increase of intracellular ROS level was observed when the cells were treated with 25-125 lM delphinidin 3-sambubioside obtained from the dried flower of Hibiscus sabdariffa. 47 Also, oxidative stress-induced ROS production was observed in HepG2 cells treated with an anthocyaninrich extract from Thai black sticky rice. 48 According to literature data the in vitro antioxidant potential of anthocyanins is related to their highly electrondeficient form of flavylium cation.…”

Section: Intracellular Rosmentioning

confidence: 99%

Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells

Rugină

Sconţa²,

Leopold³

et al. 2012

Journal of Medicinal Food

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The present study evaluates the antioxidant activity of two Aronia melanocarpa cultivars-Viking and Aronand of Aronia prunifolia hybrid in relationship with their phytochemical composition regarding the contents of total phenolics, flavonoids, procyanidins, and monomeric anthocyanins. The antioxidant capacity of the mentioned extracts of chokeberries was evaluated through five complementary assays: 2,2 0 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), H2O2 scavenging potential, oxygen radical absorbance capacity, ferric reducing antioxidant power, and cupric ion reducing antioxidant capacity. A. prunifolia hybrid was found to have the highest antioxidant activity and to be the richest in polyphenols, procyanidins, and anthocyanins compared with the A. melanocarpa cultivars. A good correlation was observed between antioxidant activity and total procyanidin and anthocyanin content. Cyanidin glycosides inhibited HeLa human cervical tumor cell proliferation and increased generation of reactive oxygen species after 48 h of treatment, suggesting that they could be responsible for the antiproliferative activity. These results may be significant for industry concerning food quality and disease prevention.

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Section: Intracellular Rosmentioning

confidence: 99%

Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells

Rugină

Sconţa²,

Leopold³

et al. 2012

Journal of Medicinal Food

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“…Red Hibiscus (Hibiscus rosa-sinensis) is a widely grown evergreen ornamental herbs, shrubs and trees of the tropics and sub-tropics which are grown as landscape plants, attractive roadside plants, border plants or as a container plants in greenhouses (Hou et al 2005). It belongs to the family Malvaceae and are reported to posses various medicinal properties viz: regulation of menstral cycle, curing hypoglycemia, potentiate hair growth, antihypertensive, anti-tumour, antioxidant and even treatment of veneral diseases{Hirunpanich et al (2006), Chang et al (2006), Herrara (2004), Palaniswamy (2003) and Telefor et al (1998)}.…”

Section: Introductionmentioning

confidence: 99%

Control of Reproduction in Oreochromis niloticus (Linnaeus 1758) Using Hibiscus Rosa-sinensis (Linn.) Leaf Meal as Reproduction Inhibitor

Jegede¹

2010

JAS

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Hibiscus rosa-sinensis leaf (HLM) was added to a basal diet (350g crude protein and 18.5MJ gross energy/kg diet) at 0, 1.0, 2.0, 3.0 or 4.0 g/kg diets and fed to mixed-sex Oreochromis niloticus for 60 days to evaluate the effects on growth, feed conversion ratio, reproduction traits, and histology of gonads. There were no variations (p >0.05) in growth parameters and feed conversion ratio. Indices of reproduction traits decreased with increasing dietary HLM levels. Fish fed with the basal diet had higher and better indices of reproduction traits (P<0.05) than the fish fed with HLM diets. Fish fed 0g HLM/kg diet showed normal testicular and ovarian tissues, and no lesions were observed. Fish fed 1.0g HLM/kg diet showed slight increase in interstitial cells in testes. Fish fed 2.0g HLM/kg diet showed swollen spermatids nuclei, increased interstitial cells and focal necrosis in testes; and hydropic degeneration, ruptured follicles, granulomatous inflammation in the insterstitium and necrosis in ovaries. Fish fed 3.0g HLM/kg diet exhibited atrophy of seminiferous tubules in testes. Fish fed 4.0g HLM/kg diet, there was disintegration of spermatids and necrosis in testes and severe atretic follicles in ovaries. Reproduction traits and histological observations of gonads in O. niloticus fed high dietary HLM levels revealed that Hibiscus rosa-sinensis leaves may be effective as a reproduction inhibitor in O. niloticus. Keywords:Hibiscus rosa-sinensis, Reproduction inhibitor, Gonad histology, Oreochromis niloticus IntroductionRed Hibiscus (Hibiscus rosa-sinensis) is a widely grown evergreen ornamental herbs, shrubs and trees of the tropics and sub-tropics which are grown as landscape plants, attractive roadside plants, border plants or as a container plants in greenhouses (Hou et al 2005). It belongs to the family Malvaceae and are reported to posses various medicinal properties viz: regulation of menstral cycle, curing hypoglycemia, potentiate hair growth, antihypertensive, anti-tumour, antioxidant and even treatment of veneral diseases{Hirunpanich et al (2006), Chang et al (2006), Herrara (2004), Palaniswamy (2003 and Telefor et al (1998)}.Hibiscus rosa-sinensis had also been used as fertility control agent in some animal models {Zhou ), Jiang (1998), Tan (1983), Farnsworth (1982 and Tiwari (1982)}. The flowers have been reported to posses anti-implantation and anti-spermatogenic activities (Murthy et al 1997). Vasudeva and Sharma (2007) reported a post-coital activity of ether extract of Hibiscus rosa-sinensis roots administered orally to colony-breed female albino rats(Wister strain) and adult albino mice.Tilapias constitute one of the most productive and internationally traded food fish in the world (Modadugu and Belen 2004). They are a major protein source in many of the developing countries. The commodity is not only the second most important farmed fish globally (next to carp) but also described as the most important aquaculture species of the 21 st century (Shelton 2002).(FAO 2006) reported that farmed ...

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“…Based on the strategies, ROS-generating reagents including natural products derived substances, especially phenolic compounds, have received much attention due to their cytocidal effects on tumor cells but little on normal cells. In this regard, like the cytocidal effects of cyanidin-3-rutinoside on leukemia cells [10], delphinidin 3-sambubioside has also been demonstrated to induce apoptosis in HL-60 through ROS-mediated mitochondria pathway [78], suggesting these anthocyanins are good candidates for ROS-generating reagents, thereby possibly potentiate the action of ATO. Indeed, quercetin and/or genistein are flavonoid with multiple biochemical effects such as downregulation of phosphoinositide 3-kinase/Akt signaling pathway and NF-κB transcription factor activity [79,80], tyrosine kinase inhibition [81,82].…”

Section: Potential Future Application Of Polyphenolic Compounds Alonmentioning

confidence: 99%

Cytocidal Effects of Polyphenolic Compounds, Alone or in Combination with, Anticancer Drugs Against Cancer Cells: Potential Future Application of the Combinatory Therapy

Yuan¹,

Imai²,

Kikuchi³

et al. 2012

Apoptosis and Medicine

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Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway

Cited by 138 publications

References 39 publications

Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells

Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells

Control of Reproduction in Oreochromis niloticus (Linnaeus 1758) Using Hibiscus Rosa-sinensis (Linn.) Leaf Meal as Reproduction Inhibitor

Cytocidal Effects of Polyphenolic Compounds, Alone or in Combination with, Anticancer Drugs Against Cancer Cells: Potential Future Application of the Combinatory Therapy

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