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Cited by 93 publications
(70 citation statements)
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“…The NP is a gelatinous matrix that is composed predominantly of Type II collagen (Col II) and proteoglycans, with high water content. This arrangement contributes to its hydrostatic pressurization and resistance to compressive forces [13]. The AF is a thick and dense structure, which is divided into the outer and inner annulus.…”
Section: Introductionmentioning
confidence: 99%
“…The NP is a gelatinous matrix that is composed predominantly of Type II collagen (Col II) and proteoglycans, with high water content. This arrangement contributes to its hydrostatic pressurization and resistance to compressive forces [13]. The AF is a thick and dense structure, which is divided into the outer and inner annulus.…”
Section: Introductionmentioning
confidence: 99%
“…MMPs are essential in the catabolism of ECM in intervertebral disc degeneration,46, 47, 48 as well as Adamts‐5, which are mainly responsible for the degradation of aggrecan. Studies have reported that oxidative stress could regulate the expression of MMPs or Adamts in the pathogenesis of IDD and other degenerative diseases 49, 50, 51.…”
Section: Discussionmentioning
confidence: 99%
“…Wang et al 9 demonstrated significant changes in disc morphology, the activity of associated inflammatory factors (prostaglandin E2, 6-keto-prostaglandin F1 alpha) and collagenase (MMP-1) levels during cervical degenerative processes induced by cervical dynamic and static imbalance in rats. Changes in various inflammatory factors have also been identified during processes of intervertebral disc degeneration [24][25][26][27][28] . It was therefore speculated that cervical dynamic and static imbalances may cause an X-ray appearance of cervical degeneration, accompanied by changes in intervertebral disc cells and extracellular matrix, which provided direction for further study.…”
Section: ■ Discussionmentioning
confidence: 99%